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Controversies about the subcellular localization and mechanisms of action of the Alzheimer's disease-protective CD33 splice variant

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References

  1. Estus S, Shaw BC, Devanney N, Katsumata Y, Press EE, Fardo DW (2019) Evaluation of CD33 as a genetic risk factor for Alzheimer’s disease. Acta Neuropathol 138:187–199

    Article  CAS  Google Scholar 

  2. Gosselin D, Skola D, Coufal NG et al (2017) An environment-dependent transcriptional network specifies human microglia identity. Science. https://doi.org/10.1126/science.aal3222

    Article  PubMed  PubMed Central  Google Scholar 

  3. Griciuc A, Serrano-Pozo A, Parrado AR et al (2013) Alzheimer’s disease risk gene CD33 inhibits microglial uptake of amyloid beta. Neuron 78:631–643

    Article  CAS  Google Scholar 

  4. Hernandez-Caselles T, Martinez-Esparza M, Perez-Oliva AB et al (2006) A study of CD33 (SIGLEC-3) antigen expression and function on activated human T and NK cells: two isoforms of CD33 are generated by alternative splicing. J Leukoc Biol 79:46–58

    Article  CAS  Google Scholar 

  5. Kou J, Kovacs GG, Höftberger R et al (2011) Peroxisomal alterations in Alzheimer’s disease. Acta Neuropathol 122:271–283

    Article  CAS  Google Scholar 

  6. Perez-Oliva AB, Martinez-Esparza M, Vicente-Fernandez JJ, Corral-San Miguel R, Garcia-Penarrubia P, Hernandez-Caselles T (2011) Epitope mapping, expression and post-translational modifications of two isoforms of CD33 (CD33M and CD33m) on lymphoid and myeloid human cells. Glycobiology 21:757–770

    Article  CAS  Google Scholar 

  7. Schwarz F, Springer SA, Altheide TK, Varki NM, Gagneux P, Varki A (2016) Human-specific derived alleles of CD33 and other genes protect against postreproductive cognitive decline. Proc Natl Acad Sci USA 113:74–79

    Article  CAS  Google Scholar 

  8. Siddiqui SS, Springer SA, Verhagen A et al (2017) The Alzheimer’s disease-protective CD33 splice variant mediates adaptive loss of function via diversion to an intracellular pool. J Biol Chem 292:15312–15320

    Article  CAS  Google Scholar 

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Acknowledgements

We thank Steven Estus (U. Kentucky), Nissi Varki (UCSD) and Pascal Gagneux (UCSD) for helpful comments. Address inquiries about antibody A16121H to wjiang@biolegend.com. Supported by a Cure Alzheimer’s Fund Grant to A. V.

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Author notes

  1. Shoib S. Siddiqui

    Present address: American University of Ras Al Khaimah (AURAK), Ras Al Khaimah, UAE

  2. Stevan Springer

    Present address: University of Prince Edward Island, Charlottetown, Canada

Authors and Affiliations

  1. Departments of Medicine and Cellular and Molecular Medicine, University of California, San Diego, San Diego, USA

    Sudeshna Saha, Shoib S. Siddiqui, Naazneen Khan, Andrea Verhagen, Stevan Springer, Pradipta Ghosh & Ajit Varki

  2. Center for Academic Research and Training in Anthropogeny, University of California, San Diego, San Diego, USA

    Sudeshna Saha, Shoib S. Siddiqui, Naazneen Khan, Andrea Verhagen & Ajit Varki

  3. BioLegend Inc., San Diego, CA, USA

    Weiping Jiang

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  1. Sudeshna Saha
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Correspondence to Ajit Varki.

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Saha, S., Siddiqui, S.S., Khan, N. et al. Controversies about the subcellular localization and mechanisms of action of the Alzheimer's disease-protective CD33 splice variant. Acta Neuropathol 138, 671–672 (2019). https://doi.org/10.1007/s00401-019-02065-1

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  • DOI: https://doi.org/10.1007/s00401-019-02065-1

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