Abstract
Virtually all phases of spinal cord injury pathogenesis, including inflammation, cell proliferation and differentiation, as well as tissue remodeling, are mediated in part by infiltrating monocyte-derived macrophages. It is now clear that these infiltrating macrophages have distinct functions from resident microglia and are capable of mediating both harmful and beneficial effects after injury. These divergent effects have been largely attributed to environmental cues, such as specific cytokines, that influence the macrophage polarization state. In this review, we also consider the possibility that different macrophage origins, including the spleen, bone marrow, and local self-renewal, may also affect macrophage fate, and ultimately their function that contribute to the complex pathobiology of spinal cord injury.
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Change history
22 April 2019
The original version of the article contains a labeling error in Fig. 2. The boxed molecular description of pro-inflammatory and anti-inflammatory macrophages were switched. Ly6C<Superscript>Hi</Superscript>, Cx3Cr1<Superscript>Lo</Superscript>, Ccr2<Superscript>Hi</Superscript> should have been associated with pro-inflammatory macrophages on the left, and Ly6C<Superscript>Lo</Superscript>, Cx3Cr1<Superscript>Hi</Superscript>, Ccr2<Superscript>Lo</Superscript> should have been associated with anti-inflammatory macrophages on the right.
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This manuscript was supported by NINDS R01NS081040, the Buoniconti Fund, and The Miami Project to Cure Paralysis. CBR is supported by University of Miami Fellowship.
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Milich, L.M., Ryan, C.B. & Lee, J.K. The origin, fate, and contribution of macrophages to spinal cord injury pathology. Acta Neuropathol 137, 785–797 (2019). https://doi.org/10.1007/s00401-019-01992-3
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DOI: https://doi.org/10.1007/s00401-019-01992-3