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Primary intracranial sarcomas with DICER1 mutation often contain prominent eosinophilic cytoplasmic globules and can occur in the setting of neurofibromatosis type 1

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Acknowledgements

D.A.S. is supported by NIH Director’s Early Independence Award (DP5 OD021403) and the UCSF Physician-Scientist Scholar Program.

Data availability

Scanned image files of the H&E stained slides from which representative images are presented are available for downloading and viewing at the following link: https://figshare.com/projects/Primary_intracranial_sarcoma_with_myogenic_differentiation_and_DICER1_mutation/57704. Sequencing and methylation data files are available from the authors upon request.

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Authors and Affiliations

  1. Department of Pathology, University of California, San Francisco, CA, USA

    Julieann C. Lee, Sean P. Ferris, Emily A. Sloan, Jeffrey W. Hofmann, Jessica Van Ziffle, Courtney Onodera, James P. Grenert, Soo-Jin Cho, Andrew E. Horvai, Arie Perry & David A. Solomon

  2. Department of Radiology and Biomedical Imaging, University of California, San Francisco, CA, USA

    Javier E. Villanueva-Meyer

  3. Department of Pathology, University of Louisville, Louisville, KY, USA

    Eyas M. Hattab

  4. Department of Neurological Surgery, University of Louisville, Louisville, KY, USA

    Brian J. Williams

  5. Department of Pathology, UCSF Benioff Children’s Hospital, Oakland, CA, USA

    Hua Guo

  6. Division of Hematology/Oncology, UCSF Benioff Children’s Hospital, Oakland, CA, USA

    Joseph Torkildson

  7. Clinical and Pathology Laboratory, Fundacion Santa Fe de Bogota Hospital Universitario, Bogota, Colombia

    Adriana Florez

  8. Clinical Cancer Genomics Laboratory, University of California, San Francisco, CA, USA

    Jessica Van Ziffle, Courtney Onodera, James P. Grenert & David A. Solomon

  9. Hopp Children’s Cancer Center Heidelberg (KiTZ), Heidelberg, Germany

    David T. W. Jones & Stefan M. Pfister

  10. Pediatric Glioma Research Group, German Cancer Research Center (DKFZ), Heidelberg, Germany

    David T. W. Jones

  11. Division of Pediatric Neuro-Oncology, German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany

    Stefan M. Pfister

  12. Department of Pediatric Hematology and Oncology, Heidelberg University Hospital, Heidelberg, Germany

    Stefan M. Pfister

  13. Department of General Pathology, Institute of Pathology, Heidelberg University Hospital, Heidelberg, Germany

    Christian Koelsche

  14. Clinical Cooperation Unit Neuropathology, German Cancer Research Center (DKFZ), German Consortium for Translational Cancer Research (DKTK), Heidelberg, Germany

    Andreas von Deimling & Andrey Korshunov

  15. Department of Neuropathology, Institute of Pathology, Heidelberg University Hospital, Heidelberg, Germany

    Andreas von Deimling & Andrey Korshunov

  16. Department of Neurological Surgery, University of California, San Francisco, CA, USA

    Arie Perry

Authors
  1. Julieann C. Lee
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  2. Javier E. Villanueva-Meyer
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  3. Sean P. Ferris
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  4. Emily A. Sloan
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  5. Jeffrey W. Hofmann
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  6. Eyas M. Hattab
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  7. Brian J. Williams
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  8. Hua Guo
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  9. Joseph Torkildson
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  10. Adriana Florez
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  11. Jessica Van Ziffle
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  12. Courtney Onodera
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  13. James P. Grenert
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  14. Soo-Jin Cho
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  15. Andrew E. Horvai
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  16. David T. W. Jones
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  17. Stefan M. Pfister
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  18. Christian Koelsche
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  19. Andreas von Deimling
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  20. Andrey Korshunov
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  21. Arie Perry
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  22. David A. Solomon
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Corresponding author

Correspondence to David A. Solomon.

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Ethical approval

This study was approved by the Committee on Human Research of the University of California, San Francisco, with a waiver of patient consent.

Conflict of interest

The authors declare that they have no competing interests related to this study.

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Lee, J.C., Villanueva-Meyer, J.E., Ferris, S.P. et al. Primary intracranial sarcomas with DICER1 mutation often contain prominent eosinophilic cytoplasmic globules and can occur in the setting of neurofibromatosis type 1. Acta Neuropathol 137, 521–525 (2019). https://doi.org/10.1007/s00401-019-01960-x

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  • DOI: https://doi.org/10.1007/s00401-019-01960-x

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