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HEIRECA! The HEIdelberg REvolution of CAncer classification and what it means for neurooncology and neuropathology

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References

  1. Capper D, Jones DTW, Sill M, Hovestadt V, Schrimpf D, Sturm D et al (2018) DNA methylation-based classification of central nervous system tumours. Nature 555:469–474

    Article  PubMed  CAS  PubMed Central  Google Scholar 

  2. Capper D, Stichel D, Sahm F, Jones DTW, Schrimpf D, Sill M et al (2018) Practical implementation of DNA methylation and copy-number-based brain tumor diagnostics: the Heidelberg experience. Acta Neuropathol. https://doi.org/10.1007/s00401-018-1879-y

    Article  PubMed  PubMed Central  Google Scholar 

  3. Capper D, Engel NW, Stichel D, Lechner M, Glöss S, Schmid S et al (2018) DNA methylation-based reclassification of olfactory neuroblastoma. Acta Neuropathol. https://doi.org/10.1007/s00401-018-1854-7

    Article  PubMed  PubMed Central  Google Scholar 

  4. Cavalli FMG, Hübner JM, Sharma T, Luu B, Sill M, Zapotocky M et al (2018) Heterogeneity within the PF-EPN-B ependymoma subgroup. Acta Neuropathol. https://doi.org/10.1007/s00401-018-1888-x

    Article  PubMed  Google Scholar 

  5. Deng MY, Sill M, Chiang J, Schittenhelm J, Ebinger M, Schuhmann MU et al (2018) Molecularly defined diffuse leptomeningeal glioneuronal tumor (DLGNT) comprises two subgroups with distinct clinical and genetic features. Acta Neuropathol. https://doi.org/10.1007/s00401-018-1865-4

    Article  PubMed  Google Scholar 

  6. Hovestadt V, Remke M, Kool M, Pietsch T, Northcott PA, Fischer R et al (2013) Robust molecular subgrouping and copy-number profiling of medulloblastoma from small amounts of archival tumour material using high-density DNA methylation arrays. Acta Neuropathol 125:913–916

    Article  PubMed  PubMed Central  Google Scholar 

  7. Koelsche C, Mynarek M, Schrimpf D, Bertero L, Serrano J, Sahm F et al (2018) Primary intracranial spindle cell sarcoma with rhabdomyosarcoma-like features share a highly distinct methylation profile and DICER1 mutations. Acta Neuropathol. https://doi.org/10.1007/s00401-018-1871-6

    Article  PubMed  PubMed Central  Google Scholar 

  8. Korshunov A, Sahm F, Stichel D, Schrimpf D, Ryzhova M, Zheludkova O et al (2018) Molecular characterization of medulloblastomas with extensive nodularity (MBEN). Acta Neuropathol. https://doi.org/10.1007/s00401-018-1840-0

    Article  PubMed  PubMed Central  Google Scholar 

  9. Louis DN, Perry A, Reifenberger G, von Deimling A, Figarella-Branger D, Cavenee WK et al (2016) The 2016 world health organization classification of tumors of the central nervous system: a summary. Acta Neuropathol 131:803–820

    Article  PubMed  Google Scholar 

  10. Pajtler KW, Wen J, Sill M, Lin T, Orisme W, Tang B et al (2018) Molecular heterogeneity and CXorf67 alterations in posterior fossa group A (PFA) ependymomas. Acta Neuropathol. https://doi.org/10.1007/s00401-018-1877-0

    Article  PubMed  Google Scholar 

  11. Pinto EM, Hamideh D, Bahrami A, Orr BA, Lin T, Pounds T et al (2018) Malignant rhabdoid tumors originating within and outside the central nervous system are clinically and molecularly heterogeneous. Acta Neuropathol. https://doi.org/10.1007/s00401-018-1814-2

    Article  PubMed  Google Scholar 

  12. Reinhardt A, Stichel D, Schrimpf D, Sahm F, Korshunov A, Reuss DE et al (2018) Anaplastic astrocytoma with piloid features, a novel molecular class of IDH wildtype glioma with recurrent MAPK pathway, CDKN2A/B and ATRX alterations. Acta Neuropathol. https://doi.org/10.1007/s00401-018-1837-8

    Article  PubMed  PubMed Central  Google Scholar 

  13. Sievers P, Stichel D, Schrimpf D, Sahm F, Koelsche C, Reuss DE et al (2018) FGFR1:TACC1 fusion is a frequent event in molecularly defined extraventricular neurocytoma. Acta Neuropathol. https://doi.org/10.1007/s00401-018-1882-3

    Article  PubMed  PubMed Central  Google Scholar 

  14. Solomon DA, Korshunov A, Sill M, Jones DTW, Kool M, Pfister SM et al (2018) Myxoid glioneuronal tumor of the septum pellucidum and lateral ventricle is defined by a recurrent PDGFRA p. K385 mutation and DNT-like methylation profile. Acta Neuropathol. https://doi.org/10.1007/s00401-018-1883-2

    Article  PubMed  Google Scholar 

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Authors and Affiliations

  1. Institute of Neuropathology, University Hospital Münster, Pottkamp 2, 48149, Münster, Germany

    Werner Paulus

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  1. Werner Paulus
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Correspondence to Werner Paulus.

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Paulus, W. HEIRECA! The HEIdelberg REvolution of CAncer classification and what it means for neurooncology and neuropathology. Acta Neuropathol 136, 177–179 (2018). https://doi.org/10.1007/s00401-018-1889-9

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  • DOI: https://doi.org/10.1007/s00401-018-1889-9

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