References
Ampie L, Choy W, DiDomenico JD et al (2016) Clinical attributes and surgical outcomes of angiocentric gliomas. J Clin Neurosci 28:117–122
Bandopadhayay P, Ramkissoon LA, Jain P et al (2016) MYB-QKI rearrangements in angiocentric glioma drive tumorigenicity through a tripartite mechanism. Nat Genet 48:273–282
Covington DB, Rosenblum MK, Brathwaite CD, Sandberg DI (2009) Angiocentric glioma-like tumor of the midbrain. Pediatr Neurosurg 45:429–433
Kline CN, Joseph NM, Grenert JP et al (2017) Targeted next-generation sequencing of pediatric neuro-oncology patients improves diagnosis, identifies pathogenic germline mutations, and directs targeted therapy. Neuro-Oncol 19:699–709
Louis DN, Ohgaki H, Wiestler OD et al (2016) WHO classification of tumours of the central nervous system. IARC, Lyon, France
Qaddoumi I, Orisme W, Wen J et al (2016) Genetic alterations in uncommon low-grade neuroepithelial tumors: BRAF, FGFR1, and MYB mutations occur at high frequency and align with morphology. Acta Neuropathol 131:833–845
Rivera-Zengotita M, Kresak J, Pincus D, Yachnis A (2014) Pediatric brainstem tumors with features of angiocentric glioma: report of two cases. J Neuropathol Exp Neurol 73:634 (Abstract 185)
Wang M, Tihan T, Rojiani AM et al (2005) Monomorphous angiocentric glioma: a distinctive epileptogenic neoplasm with features of infiltrating astrocytoma and ependymoma. J Neuropathol Exp Neurol 64:875–881
Acknowledgements
C.N.K. is supported by the Campini Foundation, Alex’s Lemonade Stand Foundation, and Cannonball Kids’ Cancer Foundation. D.A.S. is supported by NIH Director’s Early Independence Award (DP5 OD021403).
Author information
Authors and Affiliations
Contributions
Author contributions
EC, AWB, TT, AP, and DAS performed pathologic assessment. DS, JVZ, JPG, and DAS performed genomic analysis. CNK provided neuro-oncology management. NG provided neurosurgical management. EC and DAS wrote the manuscript and created the figures. All authors read and approved the final manuscript.
Corresponding author
Ethics declarations
Conflict of interest
The authors declare that they have no competing interests related to this case report.
Electronic supplementary material
Below is the link to the electronic supplementary material.
401_2017_1759_MOESM1_ESM.pdf
Supplementary Figs. 1 –4: Figure S1. Magnetic resonance imaging features of the angiocentric glioma located in the brainstem. Figure S2. Cytologic features of the angiocentric glioma located in the brainstem. Figure S3. Histologic features of the angiocentric glioma located in the brainstem. Figure S4. Chromosomal copy number plot for the angiocentric glioma located in the brainstem. (PDF 8656 kb)
Rights and permissions
About this article
Cite this article
Chan, E., Bollen, A.W., Sirohi, D. et al. Angiocentric glioma with MYB-QKI fusion located in the brainstem, rather than cerebral cortex. Acta Neuropathol 134, 671–673 (2017). https://doi.org/10.1007/s00401-017-1759-x
Received:
Revised:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s00401-017-1759-x