Skip to main content
SpringerLink
Log in

Dimethyl fumarate accelerates peripheral nerve regeneration via activation of the anti-inflammatory and cytoprotective Nrf2/HO-1 signaling pathway

  • Correspondence
  • Published:
Acta Neuropathologica Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2

References

  1. Alam J, Stewart D, Touchard C, Boinapally S, Choi AMK, Cook JL (1999) Nrf2, a cap‘n’collar transcription factor, regulates induction of the heme oxygenase-1 gene. J Biol Chem 274:26071–26078

    Article  CAS  PubMed  Google Scholar 

  2. Albrecht P, Bouchachia I, Goebels N, Henke N, Hofstetter HH, Issberner A et al (2012) Effects of dimethyl fumarate on neuroprotection and immunomodulation. J Neuroinflamm 9:163

    Article  CAS  Google Scholar 

  3. Brennan MS, Matos MF, Li B, Hronowski X, Gao Juhasz P et al (2015) Dimethyl fumarate and monoethyl fumarate exhibit differential effects on KEAP1, NRF2 activation, and glutathione depletion in vitro. PLoS One 10(3):e0120254

    Article  PubMed  PubMed Central  Google Scholar 

  4. Han R, Xiao J, Zhai H, Hao J (2016) Dimethyl fumarate attenuates experimental autoimmune neuritis through the nuclear factor erythroid-derived 2-related factor 2/hemoxygenase-1 pathway by altering the balance of M1/M2 macrophages. J Neuroinflamm 13:97

    Article  CAS  Google Scholar 

  5. Lee JM, Li J, Johnson DA, Stein TD, Kraft AD, Calkins MJ et al (2005) Nrf2, a multi-organ protector? FASEB J 19(9):1061–1066

    Article  PubMed  Google Scholar 

  6. Lin SX, Lisi L, Russo CD, Polak PE, Sharp A, Weinberg G et al (2011) The anti-inflammatory effects of dimethyl fumarate in astrocytes involve glutathione and haem oxygenase-1. ASN Neuro 3(2):art:e00055. doi:10.1042/AN20100033

    Article  Google Scholar 

  7. Linker RA, Haghikia A (2016) Dimethyl fumarate in multiple sclerosis: latest developments, evidence and place in therapy. Ther Adv Chronic Dis 7(4):198–207

    Article  PubMed  PubMed Central  Google Scholar 

  8. Linker RA, Lee DH, Ryan S, van Dam AM, Conrad R, Bista P et al (2011) Fumaric acid esters exert neuroprotective effects in neuroinflammation via activation of the Nrf2 antioxidant pathway. Brain 134(3):678–692

    Article  PubMed  Google Scholar 

  9. Otterbein LE, Soares MP, Yamashita K, Bach FH (2003) Heme oxygenase-1: unleashing the protective properties of heme. Trends Immunol 24(8):449–455

    Article  CAS  PubMed  Google Scholar 

  10. Soares MP, Bach FH (2009) Heme oxygenase-1: from biology to therapeutic potential. Trends Mol Med 15(2):50–58

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Neurology, Medical Faculty, Heinrich-Heine-University, Moorenstrasse 5, 40225, Düsseldorf, Germany

    Fabian Szepanowski, Daniel M. Donaldson, Hans-Peter Hartung, Anne K. Mausberg, Bernd C. Kieseier & Mark Stettner

  2. Department of Neurology, Medical Faculty, University Duisburg-Essen, Essen, Germany

    Anne K. Mausberg, Christoph Kleinschnitz & Mark Stettner

Authors
  1. Fabian Szepanowski
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Daniel M. Donaldson
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Hans-Peter Hartung
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Anne K. Mausberg
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Christoph Kleinschnitz
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Bernd C. Kieseier
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Mark Stettner
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Fabian Szepanowski.

Ethics declarations

Conflict of interest

FS, DMD, and AKM have nothing to disclose. HPH has received honoraria for consulting and lecturing, travel expenses for attending meetings, and financial support for research from Bayer Health Care, Biogen Idec, Genzyme, GeNeuro, Merck Serono, Novartis, Roche, Sanofi Aventis, and TEVA; CK from Ablynx, Bayer Health Care, Boehringer Ingelheim, Biogen Idec, Biotronik, Daiichi Sankyo, Eisai, Ever Pharma, Genzyme, Merck Serono, Mylan, Novartis, Roche, Sanofi Aventis, Siemens, and TEVA; BCK from Bayer Health Care, Biogen Idec, Merck Serono, Novartis, Genzyme, and TEVA. BCK is currently also employee of Biogen. MS has received honoraria for consulting and lecturing, travel expenses for attending meetings or financial support for research from Bayer Health Care, Biogen Idec, Genzyme, Novartis, Sanofi Aventis, Grifols, and TEVA.

Electronic supplementary material

Below is the link to the electronic supplementary material.

Supplementary material 1 (PDF 123 kb)

Supplementary material 2 (PDF 694 kb)

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Szepanowski, F., Donaldson, D.M., Hartung, HP. et al. Dimethyl fumarate accelerates peripheral nerve regeneration via activation of the anti-inflammatory and cytoprotective Nrf2/HO-1 signaling pathway. Acta Neuropathol 133, 489–491 (2017). https://doi.org/10.1007/s00401-017-1676-z

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00401-017-1676-z

Keywords

Search

Navigation