Skip to main content
SpringerLink
Log in

High rate of concurrent BRAF-KIAA1549 gene fusion and 1p deletion in disseminated oligodendroglioma-like leptomeningeal neoplasms (DOLN)

  • Correspondence
  • Published:
Acta Neuropathologica Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1

References

  1. Chappe C, Padovani L, Scavarda D, Forest F, Nanni-Metellus I, Loundou A, Mercurio S, Fina F, Lena G, Colin C et al (2013) Dysembryoplastic neuroepithelial tumors share with pleomorphic xanthoastrocytomas and gangliogliomas BRAF(V600E) mutation and expression. Brain Pathol 23:574–583. doi:10.1111/bpa.12048

    Article  PubMed  Google Scholar 

  2. Dasgupta T, Haas-Kogan DA (2013) The combination of novel targeted molecular agents and radiation in the treatment of pediatric gliomas. Front Oncol 3:110. doi:10.3389/fonc.2013.00110

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  3. Kim YH, Nonoguchi N, Paulus W, Brokinkel B, Keyvani K, Sure U, Wrede K, Mariani L, Giangaspero F, Tanaka Y et al (2012) Frequent BRAF gain in low-grade diffuse gliomas with 1p/19q loss. Brain Pathol 22:834–840. doi:10.1111/j.1750-3639.2012.00601.x

    Article  CAS  PubMed  Google Scholar 

  4. Lin A, Rodriguez FJ, Karajannis MA, Williams SC, Legault G, Zagzag D, Burger PC, Allen JC, Eberhart CG, Bar EE (2012) BRAF alterations in primary glial and glioneuronal neoplasms of the central nervous system with identification of 2 novel KIAA1549:BRAF fusion variants. J Neuropathol Exp Neurol 71:66–72. doi:10.1097/NEN.0b013e31823f2cb0

    Article  CAS  PubMed  Google Scholar 

  5. Perilongo G, Gardiman M, Bisaglia L, Rigobello L, Calderone M, Battistella A, Burnelli R, Giangaspero F (2002) Spinal low-grade neoplasms with extensive leptomeningeal dissemination in children. Childs Nerv Syst ChNS Off J Int Soc Pediatr Neurosurg 18:505–512. doi:10.1007/s00381-002-0626-8

    Article  Google Scholar 

  6. Rodriguez FJ, Perry A, Rosenblum MK, Krawitz S, Cohen KJ, Lin D, Mosier S, Lin MT, Eberhart CG, Burger PC (2012) Disseminated oligodendroglial-like leptomeningeal tumor of childhood: a distinctive clinicopathologic entity. Acta Neuropathol 124:627–641. doi:10.1007/s00401-012-1037-x

    Article  PubMed  Google Scholar 

  7. Rossi S, Rodriguez FJ, Mota RA, Dei Tos AP, Di Paola F, Bendini M, Agostini S, Longatti P, Jenkins RB, Giannini C (2009) Primary leptomeningeal oligodendroglioma with documented progression to anaplasia and t(1;19)(q10;p10) in a child. Acta Neuropathol 118:575–577. doi:10.1007/s00401-009-0565-5

    Article  PubMed  Google Scholar 

  8. Schniederjan MJ, Alghamdi S, Castellano-Sanchez A, Mazewski C, Brahma B, Brat DJ, Brathwaite CD, Janss AJ (2013) Diffuse leptomeningeal neuroepithelial tumor: 9 pediatric cases with chromosome 1p/19q deletion status and IDH1 (R132H) immunohistochemistry. Am J Surg Pathol 37:763–771. doi:10.1097/PAS.0b013e31827bf4cc

    Article  PubMed  Google Scholar 

  9. Sievert AJ, Lang SS, Boucher KL, Madsen PJ, Slaunwhite E, Choudhari N, Kellet M, Storm PB, Resnick AC (2013) Paradoxical activation and RAF inhibitor resistance of BRAF protein kinase fusions characterizing pediatric astrocytomas. Proc Natl Acad Sci USA 110:5957–5962. doi:10.1073/pnas.1219232110

    Article  PubMed Central  CAS  PubMed  Google Scholar 

Download references

Acknowledgments

The authors would like to thank Roxanne Marshall at UCSF for her excellent technical work performing FISH.

Author information

Author notes

    Authors and Affiliations

    1. Division of Neuropathology, Department of Pathology, Johns Hopkins Hospital, Johns Hopkins University, Sheikh Zayed Tower, Room M2101, 1800 Orleans Street, Baltimore, MD, 21231, USA

      Fausto J. Rodriguez & Peter C. Burger

    2. Department of Pathology and Laboratory Administration, Children’s Healthcare of Atlanta, 1001 Johnson Ferry Rd NE, Atlanta, GA, 30342, USA

      Matthew J. Schniederjan

    3. Department of Pediatrics, University of California San Francisco School of Medicine, 550 16th Street, San Francisco, CA, 94143, USA

      Theo Nicolaides

    4. Division of Neuropathology, Department of Pathology, University of California San Francisco School of Medicine, 505 Parnassus Avenue, San Francisco, CA, 94143, USA

      Tarik Tihan & Arie Perry

    5. Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Room G170, 1364 Clifton Rd NE, Atlanta, GA, 30322, USA

      Matthew J. Schniederjan

    Authors
    1. Fausto J. Rodriguez
      View author publications

      You can also search for this author in PubMed Google Scholar

    2. Matthew J. Schniederjan
      View author publications

      You can also search for this author in PubMed Google Scholar

    3. Theo Nicolaides
      View author publications

      You can also search for this author in PubMed Google Scholar

    4. Tarik Tihan
      View author publications

      You can also search for this author in PubMed Google Scholar

    5. Peter C. Burger
      View author publications

      You can also search for this author in PubMed Google Scholar

    6. Arie Perry
      View author publications

      You can also search for this author in PubMed Google Scholar

    Corresponding author

    Correspondence to Matthew J. Schniederjan.

    Additional information

    F. J. Rodriguez and M. J. Schniederjan contributed equally to the work.

    Rights and permissions

    Reprints and permissions

    About this article

    Check for updates. Verify currency and authenticity via CrossMark

    Cite this article

    Rodriguez, F.J., Schniederjan, M.J., Nicolaides, T. et al. High rate of concurrent BRAF-KIAA1549 gene fusion and 1p deletion in disseminated oligodendroglioma-like leptomeningeal neoplasms (DOLN). Acta Neuropathol 129, 609–610 (2015). https://doi.org/10.1007/s00401-015-1400-9

    Download citation

    • Received:

    • Revised:

    • Accepted:

    • Published:

    • Issue Date:

    • DOI: https://doi.org/10.1007/s00401-015-1400-9

    Keywords

    Search

    Navigation