Abstract
Introduction
Medulloblastoma is the commonest embryonal brain tumor in children. Their association with other neuroepithelial brain tumors is less known. Here we discuss a pediatric patient who developed esthesioneuroblastoma 2 years after treatment of medulloblastoma.
Materials and methods
A 12-year-old male presented with features of raised intracranial hypertension, and radiology showed posterior fossa midline lesion. The tumor was excised, and biopsy revealed medulloblastoma (non-WNT non-SHH type). He received chemoradiation. Two years later he presented with loss of vision, and radiology revealed a sinonasal mass with subfrontal extension. Subtotal resection was done, and biopsy showed blue round cell tumor in favor of esthesioneuroblastoma.
Result
Parents refused further treatment and the patient died 8months after the second surgery.
Conclusion
Mixed embryonal and neuroepithelial brain tumors are rare. These may have a common genetic abnormality. They have an aggressive course and bear a poor prognosis.
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Sushanta K. Sahoo: Concept and design, collection of data, manuscript drafting and reviewing. Renu Madan: Collection of data, manuscript drafting and reviewing. Debajyoti Chatterjee: Collection of data, manuscript drafting and reviewing. Mayur Parkhi: Collection of data, manuscript drafting and reviewing. Anurodh Kumar: Collection of data, manuscript drafting and reviewing.
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Sahoo, S.K., Madan, R., Chatterjee, D. et al. Medulloblastoma and esthesioneuroblastoma in a pediatric patient: a co-incidence or result of common genetic anomaly. Childs Nerv Syst 38, 1023–1027 (2022). https://doi.org/10.1007/s00381-021-05346-x
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DOI: https://doi.org/10.1007/s00381-021-05346-x