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Zotarolimus-eluting stent utilization in small-vessel coronary artery disease (ZEUS)

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Abstract

The role of the second-generation zotarolimus-eluting stent RESOLUTE in small-vessel coronary artery disease is unclear. The aim of this study was examine the angiographic results of RESOLUTE in de novo coronary lesions of ≥50 % diameter stenosis in target vessels ≤2.5 mm. From August 2008 to April 2010, 142 symptomatic patients with 159 lesions who fitted the inclusion criteria were treated with RESOLUTE. The mean age of patients was 66 ± 10 years, with male predominance (66 %). Diabetes mellitus was found in 62 (43.7 %) patients, whereas multivessel disease was observed in 105 (73.9 %). The mean stent size and length used were 2.33 ± 0.13 and 22 ± 8 mm, respectively. Follow-up angiography was performed on 143 (89.9 %) lesions in 127 (89.4 %) patients at a mean of 10.3 ± 3.6 months. Angiographic restenosis was found in 9 (6.3 %) lesions; the late loss was 0.26 ± 0.34 mm. At 1-year follow-up there were four cardiovascular deaths, two nonfatal myocardial infarctions, and six repeated revascularizations. The resultant major adverse cardiac event rate was 8.5 %. The use of RESOLUTE to treat small-vessel disease is associated with good clinical and angiographic outcomes at 1 year.

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Authors and Affiliations

  1. Cardiac Medical Unit, Grantham Hospital, 125 Wong Chuk Hang Road, Hong Kong, Hong Kong

    Man-Hong Jim, Raymond Chi-yan Fung, Andrew Kei-Yan Ng & Wing-Hing Chow

  2. Division of Cardiology, Queen Mary Hospital, Hong Kong, Hong Kong

    Kai-Hang Yiu & Chung-Wah Siu

  3. Department of Cardiology, Tan Tock Seng Hospital, Singapore, Singapore

    Hee-Hwa Ho

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  1. Man-Hong Jim
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  2. Kai-Hang Yiu
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Correspondence to Man-Hong Jim.

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Jim, MH., Yiu, KH., Fung, R.Cy. et al. Zotarolimus-eluting stent utilization in small-vessel coronary artery disease (ZEUS). Heart Vessels 29, 29–34 (2014). https://doi.org/10.1007/s00380-013-0327-0

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  • DOI: https://doi.org/10.1007/s00380-013-0327-0

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