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Serum adipocyte fatty acid-binding protein is independently associated with complex coronary lesions in patients with stable coronary artery disease

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Abstract

The association between circulating adipocyte fatty acid-binding protein (A-FABP) levels and coronary artery disease (CAD) is reported. We assessed whether plasma A-FABP levels are associated with angiographic coronary lesion morphology in patients with stable CAD. Serum A-FABP levels were analyzed in 115 patients with stable CAD (mean age 69 ± 10 years; 80 % men). These patients were angiographically studied and divided into two groups: simple lesions (n = 34) and complex lesions (n = 81). We also compared 50 age- and gender-matched controls with no evidence of CAD. Serum A-FABP levels in patients with stable CAD were significantly higher than those in controls. In patients with stable CAD, serum A-FABP levels were significantly higher in patients with complex lesions than in those with simple lesions: median (25th–75th percentile), 23.4 (17.7–30.8) vs 18.2 (12.2–24.7) ng/ml, P < 0.01. Serum A-FABP levels were also significantly associated with angiographic scores of extent of coronary lesion (r = 0.21, P = 0.02). Multiple logistic analysis that included dyslipidemia, statin therapy, and extent score demonstrated that serum A-FABP was independently associated with complex lesions. The multiple adjusted odds ratio for a complex lesion with a serum A-FABP level (per doubling) was 2.38 (95 % confidence interval, 1.03–6.41; P = 0.03). High serum A-FABP levels were significantly associated with complex coronary lesions in patients with stable CAD, suggesting that high A-FABP levels may be involved in coronary plaque vulnerability.

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Authors and Affiliations

  1. Department of Cardiology, Kagawa Prefectural Central Hospital, Kagawa, Japan

    Masahito Kajiya, Masayuki Doi, Mutsumi Iwamoto, Ko Takeda, Kazumasa Nosaka & Rie Nakayama

  2. Department of Cardiovascular Therapeutics, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1 Shikata-cho, Okayama, 700-8558, Japan

    Toru Miyoshi

  3. Department of Cardiovascular Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan

    Toru Miyoshi, Kazufumi Nakamura & Hiroshi Ito

  4. Department of Medical Technology, Okayama University Graduate School of Health Sciences, Okayama, Japan

    Shinichi Usui & Shozo Kusachi

  5. International Center, Okayama University, Okayama, Japan

    Satoshi Hirohata

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  1. Masahito Kajiya
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  2. Toru Miyoshi
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Correspondence to Toru Miyoshi.

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Kajiya, M., Miyoshi, T., Doi, M. et al. Serum adipocyte fatty acid-binding protein is independently associated with complex coronary lesions in patients with stable coronary artery disease. Heart Vessels 28, 696–703 (2013). https://doi.org/10.1007/s00380-012-0310-1

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