Skip to main content
SpringerLink
Log in

Diffusivity of intraorbital lymphoma vs. inflammation: comparison of single shot turbo spin echo and multishot echo planar imaging techniques

  • Head and Neck
  • Published:
European Radiology Aims and scope Submit manuscript

Abstract

Purpose

To compare the abilities of turbo spin-echo diffusion-weighted imaging (TSE DWI) and multi-shot echo planar DWI (MSh DWI) to discriminate orbital lymphoma from inflammatory lesions.

Materials and methods

Twenty-nine patients with pathologically confirmed lymphomas and 39 patients with inflammation were imaged with a 3.0-T system. The apparent diffusion coefficient (ADC) of each lesion was measured. Signal intensities compared to normal grey matter on conventional imaging were also measured.

Results

The ADCs derived from the TSE DWI of the lymphomas (0.68 ± 0.14 × 10−3 mm2/s) were significantly lower than those of the inflammation cases (1.04 ± 0.39 × 10−3 mm2/s; p < 0.001). The ADCs derived from MSh DWI could not be used to separate the lymphomas from the inflammation (1.16 ± 0.43 × 10−3 mm2/s vs. 1.36 ± 0.48 × 10−3 mm2/s; p = 0.06). Conventional sequences also could not separate the lymphomas from the inflammation (p > 0.05). The ROC analysis showed the best diagnostic performance with ADCs derived from TSE DWI (the area under the curve: AUC = 0.831) followed by ADC derived from MSh DWI (AUC = 0.633).

Conclusion

The ADCs derived from TSE DWI might help to differentiate orbital lymphomas from inflammation.

Key Points

• ADC of lymphoma was significantly lower than that of inflammation.

• ADC derived from TSE DWI showed the best diagnostic performance.

• This study was conducted by a 3-T MR scanner.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Fig. 1
Fig. 2
Fig. 3

Similar content being viewed by others

References

  1. Sugahara T, Korogi Y, Kochi M et al (1999) Usefulness of diffusion-weighted MRI with echo-planar technique in the evaluation of cellularity in gliomas. J Magn Reson Imaging 9:53–60

    Article  CAS  PubMed  Google Scholar 

  2. Razek AA, Elkhamary S, Mousa A (2011) Differentiation between benign and malignant orbital tumors at 3-T diffusion MR-imaging. Neuroradiology 53:517–522

    Article  PubMed  Google Scholar 

  3. Sepahdari AR, Aakalu VK, Setabutr P, Shiehmorteza M, Naheedy JH, Mafee MF (2010) Indeterminate orbital masses: restricted diffusion at MR imaging with echo-planar diffusion-weighted imaging predicts malignancy. Radiology 256:554–564

    Article  PubMed  Google Scholar 

  4. de Graaf P, Pouwels PJ, Rodjan F (2012) Single-shot turbo spin-echo diffusion-weighted imaging for retinoblastoma: initial experience. AJNR Am J Neuroradiol 33:110–118

    Article  PubMed  Google Scholar 

  5. Hiwatashi A, Yoshiura T, Togao O et al (2014) Diffusivity of intraorbital lymphoma vs. IgG4-related DISEASE: 3D turbo field echo with diffusion-sensitised driven-equilibrium preparation technique. Eur Radiol 24:581–586

    Article  PubMed  Google Scholar 

  6. Hiwatashi A, Togao O, Yamashita K et al (2016) 3D turbo field echo with diffusion-sensitized driven-equilibrium preparation technique (DSDE-TFE) versus echo planar imaging in evaluation of diffusivity of retinoblastoma. Br J Radiol 89:20160074

    Article  PubMed  PubMed Central  Google Scholar 

  7. Politi LS, Forghani R, Godi C et al (2010) Ocular adnexal lymphoma: diffusion-weighted MR imaging for differential diagnosis and therapeutic monitoring. Radiology 256:565–574

    Article  PubMed  Google Scholar 

  8. Rumboldt Z, Moses C, Wieczerzynski U, Saini R (2005) Diffusion-weighted imaging, apparent diffusion coefficients, and fluid-attenuated inversion recovery MR imaging in endophthalmitis. AJNR Am J Neuroradiol 26:1869–1872

    PubMed  Google Scholar 

  9. Al-Shafai LS, Mikulis DJ (2006) Diffusion MR imaging in a case of acute ischemic optic neuropathy. AJNR Am J Neuroradiol 27:255–257

    CAS  PubMed  Google Scholar 

  10. Chen JS, Mukherjee P, Dillon WP, Wintermark M (2006) Restricted diffusion in bilateral optic nerves and retinas as an indicator of venous ischemia caused by cavernous sinus thrombophlebitis. AJNR Am J Neuroradiol 27:1815–1816

    CAS  PubMed  Google Scholar 

  11. Kunii N, Abe T, Kawamo M, Tanioka D, Izumiyama H, Moritani T (2007) Rathke's cleft cysts: differentiation from other cystic lesions in the pituitary fossa by use of single-shot fast spin-echo diffusion-weighted MR imaging. Acta Neurochir (Wien) 149:759–769

    Article  CAS  Google Scholar 

  12. Suzuki C, Maeda M, Hori K et al (2007) Apparent diffusion coefficient of pituitary macroadenoma evaluated with line-scan diffusion-weighted imaging. J Neuroradiol 34:228–235

    Article  CAS  PubMed  Google Scholar 

  13. Mahmoud OM, Tominaga A, Amatya VJ et al (2011) Role of PROPELLER diffusion-weighted imaging and apparent diffusion coefficient in the evaluation of pituitary adenomas. Eur J Radiol 80:412–417

    Article  PubMed  Google Scholar 

  14. Yamashita K, Yoshiura T, Hiwatashi A et al (2013) High-resolution three-dimensional diffusion-weighted imaging of middle ear cholesteatoma at 3.0 T MRI: usefulness of 3D turbo field-echo with diffusion-sensitized driven-equilibrium preparation (TFE-DSDE) compared to single-shot echo-planar imaging. Eur J Radiol 82:e471–e475

    Article  PubMed  Google Scholar 

  15. Hiwatashi A, Yoshiura T, Togao O et al (2014) Evaluation of diffusivity in the anterior lobe of the pituitary gland: 3D turbo field echo with diffusion-sensitized driven-equilibrium preparation. AJNR Am J Neuroradiol 35:95–98

    Article  CAS  PubMed  Google Scholar 

  16. Hiwatashi A, Togao O, Yamashita K et al (2016) Evaluation of diffusivity in pituitary adenoma: 3D turbo field echo with diffusion-sensitized driven-equilibrium preparation. Br J Radiol 89:20150755

    Article  PubMed  PubMed Central  Google Scholar 

  17. Ries M, Jones RA, Dousset V, Moonen CT (2000) Diffusion tensor MRI of the spinal cord. Magn Reson Med 44:884–892

    Article  CAS  PubMed  Google Scholar 

  18. Demir A, Ries M, Moonen CT et al (2003) Diffusion-weighted MR imaging with apparent diffusion coefficient and apparent diffusion tensor maps in cervical spondylotic myelopathy. Radiology 229:37–43

    Article  PubMed  Google Scholar 

  19. Yamashita K, Yoshiura T, Hiwatashi A et al (2011) Detection of middle ear cholesteatoma by diffusion-weighted MR imaging: multishot echo-planar imaging compared with single-shot echo-planar imaging. AJNR Am J Neuroradiol 32:1915–1918

    Article  CAS  PubMed  Google Scholar 

  20. Dubrulle F, Souillard R, Chechin D, Vaneecloo FM, Desaulty A, Vincent C (2006) Diffusion-weighted MR imaging sequence in the detection of postoperative recurrent cholesteatoma. Radiology 238:604–610

    Article  PubMed  Google Scholar 

  21. Sakamoto J, Sasaki Y, Otonari-Yamamoto M, Sano T (2012) Comparison of various methods for quantification of apparent diffusion coefficient of head and neck lesions with HASTE diffusion-weighted MR imaging. Oral Surg Oral Med Oral Pathol Oral Radiol 114:266–276

    Article  PubMed  Google Scholar 

  22. Sigmund EE, Gutman D (2011) Diffusion-weighted imaging of the brain at 7 T with echo-planar and turbo spin echo sequences: preliminary results. Magn Reson Imaging 29:752–765

    Article  PubMed  Google Scholar 

  23. Babourina-Brooks B, Cowin GJ, Wang D (2012) Diffusion-weighted imaging in the prostate: an apparent diffusion coefficient comparison of half-Fourier acquisition single-shot turbo spin-echo and echo planar imaging. Magn Reson Imaging 30:189–194

    Article  PubMed  Google Scholar 

  24. Verhappen MH, Pouwels PJ, Ljumanovic R et al (2012) Diffusion-weighted MR imaging in head and neck cancer: comparison between half-fourier acquired single-shot turbo spin-echo and EPI techniques. AJNR Am J Neuroradiol 33:1239–1246

    Article  CAS  PubMed  Google Scholar 

  25. Kozlowski P, Chang SD, Goldenberg SL (2008) Diffusion-weighted MRI in prostate cancer -- comparison between single-shot fast spin echo and echo planar imaging sequences. Magn Reson Imaging 26:72–76

    Article  PubMed  Google Scholar 

  26. Guo AC, Cummings TJ, Dash RC, Provenzale JM (2002) Lymphomas and high-grade astrocytomas: comparison of water diffusibility and histologic characteristics. Radiology 224:177–183

    Article  PubMed  Google Scholar 

  27. Rieseberg S, Frahm J, Finsterbusch J (2002) Two-dimensional spatially-selective RF excitation pulses in echo-planar imaging. Magn Reson Med 47:1186–1193

    Article  PubMed  Google Scholar 

  28. Pfeuffer J, van de Moortele PF, Yacoub E et al (2002) Zoomed functional imaging in the human brain at 7 Tesla with simultaneous high spatial and high temporal resolution. Neuroimage 17:272–286

    Article  PubMed  Google Scholar 

  29. Porter DA, Heidemann RM (2009) High resolution diffusion-weighted imaging using readout-segmented echo-planar imaging, parallel imaging and a two-dimensional navigator-based reacquisition. Magn Reson Med 62:468–475

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Clinical Radiology, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 812-8582, Japan

    Akio Hiwatashi, Osamu Togao, Koji Yamashita, Kazufumi Kikuchi, Ryotaro Kamei & Hiroshi Honda

  2. Department of Ophthalmology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan

    Hiroshi Yoshikawa

  3. MR Clinical Science, Philips Electronics Japan, Tokyo, Japan

    Atsushi Takemura

Authors
  1. Akio Hiwatashi
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Osamu Togao
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Koji Yamashita
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Kazufumi Kikuchi
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Ryotaro Kamei
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Hiroshi Yoshikawa
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Atsushi Takemura
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. Hiroshi Honda
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Akio Hiwatashi.

Ethics declarations

Guarantor

The scientific guarantor of this publication is Hiroshi Honda.

Conflict of interest

Mr. Atsushi Takemura declares relationships with the following companies: Philips Electronics, Japan. However, he was not involved in data analysis of this study.

Funding

The authors state that this work was supported by JSPS KAKENHI Grant Numbers JP26461826 and 17K10408.

Statistics and biometry

Mr. Junji Kishimoto kindly provided statistical advice for this manuscript.

Informed consent

Written informed consent was waived by the Institutional Review Board.

Ethical approval

Institutional Review Board approval was obtained.

Study subjects or cohorts overlap

Some study subjects or cohorts have been previously reported in ISMRM 2016.

Methodology

• retrospective

• observational

• performed at one institution

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Hiwatashi, A., Togao, O., Yamashita, K. et al. Diffusivity of intraorbital lymphoma vs. inflammation: comparison of single shot turbo spin echo and multishot echo planar imaging techniques. Eur Radiol 28, 325–330 (2018). https://doi.org/10.1007/s00330-017-4995-5

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00330-017-4995-5

Keywords

Search

Navigation