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Association between daily level of objective physical activity and C-Reactive protein in a representative national sample of adults with self-reported diagnosed arthritis or fibromyalgia

  • Observational Research
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Abstract

Purpose

Examine the association between physical activity and sedentary time with high sensitivity C-Reactive protein levels in adults with arthritis and fibromyalgia. We also investigated the dose of physical activity that was associated with lower clinical levels of high sensitivity C-Reactive protein (< 3 mg/L).

Materials and methods

Observational design was used to evaluate the variables of interest-based on the Canadian Health Measures Survey cycle 1–3 (2007–2012). Generalized adjusted additive models were used to explore the shape of the association between high sensitivity C-Reactive protein, daily physical activity, step count and sedentary time. High sensitivity C-Reactive protein was measured with blood samples. Physical activity, number of steps and sedentary time were objectively assessed using an Actical accelerometer.

Results

Daily moderate to vigorous physical activity and step count were significantly associated with lower high sensitivity C-Reactive protein levels, but daily light physical activity and sedentary time were not associated with high sensitivity C-Reactive protein levels, even after controlling for age, sex, daily smoking, body mass index, household income, level of education levels, marital status, work year and accelerometer wear time and season of accelerometer. Non-linear dose–response patterns were observed between daily moderate to vigorous physical activity as well as step count with high sensitivity C-Reactive protein levels. Lower high sensitivity C-Reactive protein levels were associated with 1–150 min of daily moderate to vigorous physical activity and with daily step count starting at 4000 in people with arthritis. Adults with fibromyalgia had lower levels of high sensitivity C-Reactive protein when engaging in 10–35 min of daily moderate to vigorous physical activity and in 5000–9000 daily steps. Optimal and specific doses of daily moderate to vigorous physical activity and steps were independently related to lower high sensitivity C-Reactive protein levels in adults with arthritis and fibromyalgia.

Conclusions

Daily moderate to vigorous physical activity and step count were associated with high sensitivity C-Reactive protein levels that were below the clinical threshold. Given the positive outcomes of physical activity on health, adults with arthritis and fibromyalgia may benefit from these specific recommendations.

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Acknowledgement

The authors would like to thank the participants of the Canadian Health Measures Survey as well as all staff at Statistics Canada involved in the operations of the survey.

Funding

The authors report no financial conflicts of interest. Celia Kingsbury is supported by the Canadian Institutes of Health Research: Undergraduate: Summer Studentship Award (2019). Paquito Bernard is supported by a salary award from the Fonds de recherche du Québec–Santé. The funders had no role in study design, data collection, and analysis, decision to publish, or preparation of the manuscript.

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Authors and Affiliations

  1. Department of Physical Activity Sciences, Faculté des sciences, Université du Québec à Montréal, UQÀM, Complexe des Sciences, Pavillon des Sciences Biologiques (SB), Local: SB-4445, 141, Avenue du Président Kennedy, Montréal, Québec, H2X 1Y4, Canada

    Celia Kingsbury, Anthony. D. Karelis, Gabriel Hains-Monfette & Paquito Bernard

  2. Research Center, University Institute of Mental Health at Montreal, Montréal, QC, Canada

    Celia Kingsbury, Gabriel Hains-Monfette & Paquito Bernard

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  1. Celia Kingsbury
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Contributions

CK and PB conceived the study. PB and GH-M provided statistical expertise in the complex survey. GH-M and CK conducted the primary statistical analyses. GH-M and CK wrote the Results section. CK, AK and PB wrote the other sections. All authors contributed to the refinement of the study protocol and approved the final manuscript.

Corresponding author

Correspondence to Celia Kingsbury.

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Kingsbury C Karelis A, Hains-Monfette G, and Bernard P declare that they have no conflicts of interest.

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Kingsbury, C., Karelis, A., Hains-Monfette, G. et al. Association between daily level of objective physical activity and C-Reactive protein in a representative national sample of adults with self-reported diagnosed arthritis or fibromyalgia. Rheumatol Int 40, 1463–1471 (2020). https://doi.org/10.1007/s00296-020-04571-y

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