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Incidence of malignancy in Takayasu arteritis in Korea

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Abstract

Cancer is associated with autoimmune diseases. This study aimed to estimate the incidence of cancer in a cohort of patients with Takayasu arteritis (TA) and to compare this incidence with the general population cancer rate in South Korea in a retrospective cohort study. The medical records of TA patients who underwent medical care at our institution between 1979 and 2009 were reviewed. The 2008 National Cancer Registry was used as the reference to calculate the standardized incidence ratio (SIR). The mean age of 180 patients was 48.6 ± 14.3 years, and 87.2 % of the patients were female. During the follow-up of 2,285 person years, 10 females developed cancer. Breast cancer was the most common malignancy with three cases, followed by two endometrial, one gastric, one colon, one pancreatic, one myelodysplastic syndrome (MDS) with refractory anemia with excess blasts, and one multiple myeloma. The SIR of cancer in TA was comparable with that of the general population at 1.3 [95 % confidence interval (CI) 0.6–2.3]; however, the risk of MDS was significantly increased (SIR 51.3; 95 % CI 1.3–285.7). While two patients with hematologic malignancies died, all TA patients with non-hematologic malignancies were still alive during the follow-up period. The overall risk of malignancy is not increased in TA. Further work is needed to determine if TA is associated with an increased risk of certain hematologic malignancies.

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References

  1. Lupi-Herrera E, Sanchez-Torres G, Marcushamer J, Mispireta J, Horwitz S, Vela JE (1977) Takayasu’s arteritis. Clinical study of 107 cases. Am Heart J 93(1):94–103

    Article  CAS  PubMed  Google Scholar 

  2. Dabague J, Reyes PA (1996) Takayasu arteritis in Mexico: a 38-year clinical perspective through literature review. Int J Cardiol 54(Suppl):S103–S109

    Article  PubMed  Google Scholar 

  3. Arend WP, Michel BA, Bloch DA, Hunder GG, Calabrese LH, Edworthy SM, Fauci AS, Leavitt RY, Lie JT, Lightfoot RW Jr, Masi AT, McShane DJ, Mills JA, Stevens MB, Wallace SL, Zvaifler NJ (1990) The American College of Rheumatology 1990 criteria for the classification of Takayasu arteritis. Arthr Rheum 33(8):1129–1134

    Article  CAS  Google Scholar 

  4. Ishikawa K, Maetani S (1994) Long-term outcome for 120 Japanese patients with Takayasu’s disease. Clinical and statistical analyses of related prognostic factors. Circulation 90(4):1855–1860

    Article  CAS  PubMed  Google Scholar 

  5. Franklin J, Lunt M, Bunn D, Symmons D, Silman A (2006) Incidence of lymphoma in a large primary care derived cohort of cases of inflammatory polyarthritis. Ann Rheum Dis 65(5):617–622. doi:10.1136/ard.2005.044784

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  6. Kim YJ, Shim JS, Choi CB, Bae SC (2012) Mortality and incidence of malignancy in Korean patients with rheumatoid arthritis. J Rheumatol 39(2):226–232. doi:10.3899/jrheum.110704

    Article  PubMed  Google Scholar 

  7. Weng MY, Huang YT, Liu MF, Lu TH (2012) Incidence of cancer in a nationwide population cohort of 7852 patients with primary Sjogren’s syndrome in Taiwan. Ann Rheum Dis 71(4):524–527. doi:10.1136/annrheumdis-2011-200402

    Article  PubMed  Google Scholar 

  8. Bernatsky S, Kale M, Ramsey-Goldman R, Gordon C, Clarke AE (2012) Systemic lupus and malignancies. Curr Opin Rheumatol 24(2):177–181. doi:10.1097/BOR.0b013e32834ff258

    Article  CAS  PubMed  Google Scholar 

  9. Olesen AB, Svaerke C, Farkas DK, Sorensen HT (2010) Systemic sclerosis and the risk of cancer: a nationwide population-based cohort study. Br J Dermatol 163(4):800–806. doi:10.1111/j.1365-2133.2010.09861.x

    Article  CAS  PubMed  Google Scholar 

  10. Levine SM (2006) Cancer and myositis: new insights into an old association. Curr Opin Rheumatol 18(6):620–624. doi:10.1097/01.bor.0000245721.02512.77

    Article  CAS  PubMed  Google Scholar 

  11. Fain O, Hamidou M, Cacoub P, Godeau B, Wechsler B, Paries J, Stirnemann J, Morin AS, Gatfosse M, Hanslik T, Belmatoug N, Bletry O, Cevallos R, Delevaux I, Fisher E, Hayem G, Kaplan G, Le Hello C, Mouthon L, Larroche C, Lemaire V, Piette AM, Piette JC, Ponge T, Puechal X, Rossert J, Sarrot-Reynauld F, Sicard D, Ziza JM, Kahn MF, Guillevin L (2007) Vasculitides associated with malignancies: analysis of sixty patients. Arthr Rheum 57(8):1473–1480. doi:10.1002/art.23085

    Article  Google Scholar 

  12. Solans-Laque R, Bosch-Gil JA, Perez-Bocanegra C, Selva-O’Callaghan A, Simeon-Aznar CP, Vilardell-Tarres M (2008) Paraneoplastic vasculitis in patients with solid tumors: report of 15 cases. J Rheumatol 35(2):294–304

    PubMed  Google Scholar 

  13. Park JK, Gelber AC, Zheng G, McDevitt MA, Gocke CD, Baer AN (2011) Large-vessel vasculitis as an early manifestation of chronic myelomonocytic leukemia. J Clin Oncol Off J Am Soc Clin Oncol 29(20):e601–e603. doi:10.1200/JCO.2011.34.6965

    Article  Google Scholar 

  14. Delecoeuillerie G, Joly P, Cohen de Lara A, Paolaggi JB (1988) Polymyalgia rheumatica and temporal arteritis: a retrospective analysis of prognostic features and different corticosteroid regimens (11 year survey of 210 patients). Ann Rheum Dis 47(9):733–739

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  15. Kermani TA, Schafer VS, Crowson CS, Hunder GG, Gabriel SE, Ytterberg SR, Matteson EL, Warrington KJ (2010) Malignancy risk in patients with giant cell arteritis: a population-based cohort study. Arthr Care Res 62(2):149–154. doi:10.1002/acr.20062

    Google Scholar 

  16. McCarthy CJ, Sheldon S, Ross CW, McCune WJ (1998) Cytogenetic abnormalities and therapy-related myelodysplastic syndromes in rheumatic disease. Arthr Rheum 41(8):1493–1496. doi:10.1002/1529-0131(199808)41:8<1493:AID-ART21>3.0.CO;2-5

    Article  CAS  Google Scholar 

  17. Hunder GG, Bloch DA, Michel BA, Stevens MB, Arend WP, Calabrese LH, Edworthy SM, Fauci AS, Leavitt RY, Lie JT et al (1990) The American College of Rheumatology 1990 criteria for the classification of giant cell arteritis. Arthr Rheum 33(8):1122–1128

    Article  CAS  Google Scholar 

  18. Hata A, Noda M, Moriwaki R, Numano F (1996) Angiographic findings of Takayasu arteritis: new classification. Int J Cardiol 54(Suppl):S155–S163

    Article  PubMed  Google Scholar 

  19. Ulm K (1990) A simple method to calculate the confidence interval of a standardized mortality ratio (SMR). Am J Epidemiol 131(2):373–375

    CAS  PubMed  Google Scholar 

  20. Ji J, Liu X, Sundquist K, Sundquist J, Hemminki K (2010) Cancer risk in patients hospitalized with polymyalgia rheumatica and giant cell arteritis: a follow-up study in Sweden. Rheumatology (Oxford) 49(6):1158–1163. doi:10.1093/rheumatology/keq040

    Article  Google Scholar 

  21. Kermani TA, Schafer VS, Crowson CS, Hunder GG, Ytterberg SR, Matteson EL, Gabriel SE, Warrington KJ (2010) Cancer preceding giant cell arteritis: a case-control study. Arthr Rheum 62(6):1763–1769. doi:10.1002/art.27429

    Article  Google Scholar 

  22. Myklebust G, Wilsgaard T, Jacobsen BK, Gran JT (2002) No increased frequency of malignant neoplasms in polymyalgia rheumatica and temporal arteritis. A prospective longitudinal study of 398 cases and matched population controls. J Rheumatol 29(10):2143–2147

    PubMed  Google Scholar 

  23. Takeyama K, Seto M, Uike N, Hamajima N, Ino T, Mikuni C, Kobayashi T, Maruta A, Muto Y, Maseki N, Sakamaki H, Saitoh H, Shimoyama M, Ueda R (2000) Therapy-related leukemia and myelodysplastic syndrome: a large-scale Japanese study of clinical and cytogenetic features as well as prognostic factors. Int J Hematol 71(2):144–152

    CAS  PubMed  Google Scholar 

  24. Jung SW, Park JY, Kim YS, Jeen YT, Lee HS, Chun HJ, Um SH, Lee SW, Choi JH, Kim CD, Ryu HS, Hyun JH (2005) Survival analysis according to treatment modality in pancreatic cancer patient. Korean J Gastroenterol= Taehan Sohwagi Hakhoe chi 46(2):120–128

    Google Scholar 

  25. Kim JJ, Park JK, Wang YP (2011) Surgical resection of pulmonary metastasis from renal cell carcinoma. Korean J Thorac Cardiovasc Surg 44(2):159–164. doi:10.5090/kjtcs.2011.44.2.159

    Article  PubMed Central  PubMed  Google Scholar 

  26. Hill CL, Zhang Y, Sigurgeirsson B, Pukkala E, Mellemkjaer L, Airio A, Evans SR, Felson DT (2001) Frequency of specific cancer types in dermatomyositis and polymyositis: a population-based study. Lancet 357(9250):96–100. doi:10.1016/S0140-6736(00)03540-6

    Article  CAS  PubMed  Google Scholar 

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Acknowledgments

We thank the Medical Research Collaborating Center (MRCC) for their assistance with statistical analyses.

Conflict of interest

Eun Bong Lee is a consultant for Pfizer. All the other authors declare that there is no conflict of interest.

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Authors and Affiliations

  1. Division of Rheumatology, Department of Internal Medicine, Seoul National University College of Medicine, 101, Daehak-ro, Jongno-Gu, Seoul, 110-744, Korea

    Jin Kyun Park, In Ah Choi, Eun Young Lee, Yeong Wook Song & Eun Bong Lee

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  1. Jin Kyun Park
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Correspondence to Eun Bong Lee.

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Park, J.K., Choi, I.A., Lee, E.Y. et al. Incidence of malignancy in Takayasu arteritis in Korea. Rheumatol Int 34, 517–521 (2014). https://doi.org/10.1007/s00296-013-2887-9

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  • DOI: https://doi.org/10.1007/s00296-013-2887-9

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