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No association of PTPN22 gene polymorphism with rheumatoid arthritis in Turkey

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Abstract

Although the association of rheumatoid arthritis (RA) with HLA-DRB1 (shared epitope) is well demonstrated in many ethnic populations, the role of other RA-associated risk loci is not clarified. In this study, the functional single nucleotide polymorphism (SNP) of PTPN22 gene was investigated in Turkey. 167 patients with RA and 177 healthy controls are genotyped by polymerase chain reaction (PCR)-RFLP for the SNP (rs2476601, A/G) of PTPN22 gene. Polymorphic region was amplified by PCR and digested with Xcm I enzyme. Heterozygous genotype (AG) was present in 5.1% (9/177) of the controls and in 6.6% (11/167) of RA group (p = 0.55, OR 1.3, 95% CI 0.53–3.26). There was also no association between any clinical feature, RF positivity and presence of this SNP. In conclusion, the distribution of PTPN22 polymorphism did not reveal any association with RA in Turkey.

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Acknowledgments

The study is supported by Marmara University Scientific Research Fund (BAPKO) (Project no: SAG-TUS 290107-0021) and Istanbul University Research Fund (BAP).

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Authors and Affiliations

  1. Division of Rheumatology, Department of Internal Medicine, Marmara University Medical School, Tophanelioğlu Cad. 13/15, Bağlarbaşı, Uskudar, 34662, Istanbul, Turkey

    N. Sahin, F. Gunduz, N. Inanc & Haner Direskeneli

  2. Department of Physiology, Istanbul University, Istanbul Medical Faculty, Istanbul, Turkey

    G. Saruhan-Direskeneli

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  1. N. Sahin
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  2. F. Gunduz
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  3. N. Inanc
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  4. Haner Direskeneli
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  5. G. Saruhan-Direskeneli
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Correspondence to Haner Direskeneli.

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Sahin, N., Gunduz, F., Inanc, N. et al. No association of PTPN22 gene polymorphism with rheumatoid arthritis in Turkey. Rheumatol Int 30, 81–83 (2009). https://doi.org/10.1007/s00296-009-0919-2

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  • DOI: https://doi.org/10.1007/s00296-009-0919-2

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