Zusammenfassung
Bei Speicheldrüsenkarzinomen sind neben dem Staging die Tumortypisierung und das Grading nach histomorphologischen Kriterien von großer Bedeutung für die Prognose der Erkrankung und für die adäquate klinische Behandlung. Derartige Klassifikations- und Gradingsysteme werden exemplarisch für Mukoepidermoidkarzinome, adenoid-zystische Karzinome und Karzinome im pleomorphen Adenom erörtert.
Abstract
In addition to staging, histological typing and grading provide important information for prognosis and adequate treatment of salivary gland cancers. Current classification and grading systems for mucoepidermoid carcinoma, adenoid cystic carcinoma, and malignant mixed tumor (carcinoma ex pleomorphic adenoma) are discussed.
Literatur
Accetta PA, Gray GF Jr, Hunter RM, Rosenfeld L (1984) Mucoepidermoid carcinoma of salivary glands. Arch Pathol Lab Med 108: 321–325
Auclair PL, Goode RK, Ellis GL (1992) Mucoepidermoid carcinoma of intraoral salivary glands: evaluation and application of grading criteria in 143 cases. Cancer 69: 2021–2030
Batsakis JG, Luna MA, El-Naggar A (1990) Histopathologic grading of salivary gland neoplasms: III. Adenoid cystic carcinomas. Ann Otol Rhinol Laryngol 99: 1007–1009
Caselitz J, Seifert G, Grenner G, Schmidtberger R (1983) Amylase as an additional marker of salivary gland neoplasms. An immunoperoxidase study. Pathol Res Pract 176: 276–283
Chen JC, Gnepp DR, Bedrossian CW (1988) Adenoid cystic carcinoma of the salivary glands: an immunohistochemical analysis. Oral Surg Oral Med Oral Pathol 65: 316–326
Childers EL, Ellis GL, Auclair PL (1996) An immunohistochemical analysis of anti-amylase antibody reactivity in acinic cell adenocarcinoma. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 81: 691–694
Chomette G, Auriol M, Tereau Y, Vaillant JM (1982) Mucoepidermoid tumors of minor salivary glands. Clinical and pathologic correlations. Histoenzymologic and ultrastructural studies. Ann Pathol 2: 29–40
Ellis GL, Auclair PL (1996) Acinic cell adenocarcinoma. In: Atlas of tumor pathology, Third series, Fascicle 17: Tumors of the salivary glands. Armed Forces Institute of Pathology, Washington, DC, pp 183–203
Ellis GL, Auclair PL (1996) Adenoid cystic carcinoma. In: Atlas of tumor pathology, Third series, Fascicle 17: Tumors of the salivary glands. Armed Forces Institute of Pathology, Washington, DC, pp 203–216
Ellis GL, Auclair PL (1996) Malignant mixed tumor. In: Atlas of tumor pathology, Third series, Fascicle 17: Tumors of the salivary glands. Armed Forces Institute of Pathology, Washington, DC, pp 228–251
Ellis GL, Auclair PL (1996) Mucoepidermoid carcinoma. In: Atlas of tumor pathology, Third series, Fascicle 17: Tumors of the salivary glands. Armed Forces Institute of Pathology, Washington, DC, pp 155–175
Evans HL (1984) Mucoepidermoid carcinoma of salivary glands: a study of 69 cases with special attention to histologic grading. Am J Clin Pathol 81: 696–701
Foote FW, Frazell EL (1953) Tumors of the major salivary glands. Cancer 6: 1065–1133
Gnepp DR, Wenig BM (1991) Malignant mixed tumors. In: Ellis GL, Auclair PL, Gnepp DR (eds) Surgical pathology of the salivary glands. Saunders, Philadelphia, pp 350–368
Goode RK, Auclair PL, Ellis GL (1998) Mucoepidermoid carcinoma of the major salivary glands: clinical and histopathologic analysis of 234 cases with evaluation of grading criteria. Cancer 82: 1217–1224
Hamper K, Lazar F, Dietel M et al. (1990) Prognostic factors for adenoid cystic carcinoma of the head and neck: a retrospective evaluation of 96 cases. J Oral Pathol Med 19: 101–107
Hickman RE, Cawson RA, Duffy SW (1984) The prognosis for specific types of salivary gland tumors. Cancer 54: 1620–1624
Kapadia SB, Barnes L (1996) Expression of androgen receptor, gross cystic disease fluid protein, and CD44 in salivary duct carcinoma. Mod Pathol 11: 1033–1038
Matsuba HM, Spector GJ, Thawley SE et al. (1986) Adenoid cystic salivary gland carcinoma. A histopathology review of treatment failure patterns. Cancer 57: 519–524
Nascimento AG, Amaral AL, Prado LA, Kligerman J, Silveira TRP (1986) Adenoid cystic carcinoma of salivary glands. A study of 61 cases with clinicopathologic correlation. Cancer 57: 312–319
Perzin KH, Gullane P, Clairmont AC (1978) Adenoid cystic carcinoma arising in salivary glands: a correlation of histologic features and clinical course. Cancer 42: 265–282
Seifert G, Schulz J, Donath K (1977) Pathomorphologische Subklassifikation der Karzinome in pleomorphen Speicheldrüsenadenomen. Analyse von 38 Fällen. HNO 25: 337–348
Seifert G, Sobin LH (1991) Histological typing of salivary gland tumours. World Health Organization international histological classification of tumours, 2. Aufl. Springer, Berlin Heidelberg New York Tokyo
Simpson RH, Prasad AR, Lewis JE, Skalova A, David L (2003) Mucin-rich variant of salivary duct carcinoma: a clinicopathologic and immunohistochemical study of four cases. Am J Surg Pathol 27: 1070–1079
Spiro RH, Huvos AG (1992) Stage means more than grade in adenoid cystic carcinoma. Am J Surg 164: 623–628
Spiro RH, Huvos AG, Berk R, Strong EW (1978) Mucoepidermoid carcinoma of salivary gland origin. A clinicopathologic study of 367 cases. Am J Surg 136: 461–468
Spiro RH, Armstrong J, Harrison L et al. (1989) Carcinoma of major salivary glands: major trends. Arch Otolaryngol Head Neck Surg 115: 316–321
Stewart FW, Foote FW, Becker WF (1945) Mucoepidermoid tumors of salivary glands. Ann Surg 122: 820–844
Szanto PA, Luna MA, Tortoledo ME, White RA (1984) Histologic grading of adenoid cystic carcinoma of the salivary glands. Cancer 54: 1062–1069
Tomich CE (1991) Adenoid cystic carcinoma. In: Ellis GL, Auclair PL, Gnepp DR (eds) Surgical pathology of the salivary glands. Saunders, Philadelphia, pp 333–349
Tortoledo ME, Luna MA, Batsakis JG (1984) Carcinomas ex pleomorphic adenoma and malignant mixed tumors. Histomorphologic indexes. Arch Otolaryngol 110: 172–176
Interessenkonflikt:
Der korrespondierende Autor versichert, dass keine Verbindungen mit einer Firma, deren Produkt in dem Artikel genannt ist, oder einer Firma, die ein Konkurrenzprodukt vertreibt, bestehen.
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Löning, T., Jäkel, K.T. Speicheldrüsentumoren—Tumortypisierung und Grading. Pathologe 25, 38–45 (2004). https://doi.org/10.1007/s00292-003-0671-4
Issue Date:
DOI: https://doi.org/10.1007/s00292-003-0671-4
Schlüsselwörter
- Speicheldrüsentumor
- Mukoepidermoidkarzinom
- Adenoid-zystisches Karzinom
- Karzinom im pleomorphen Adenom
- Grading