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PD-1-PD-L1 immune-checkpoint blockade in malignant lymphomas

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Abstract

Tumor cells can evade immune surveillance through overexpressing the ligands of checkpoint receptors on tumor cells or adjacent cells, leading T cells to anergy or exhaustion. Growing evidence of the interaction between tumor cells and microenvironment promoted the emergence of immune-checkpoint blockade. By targeting programmed cell death-1 (PD-1) pathway, cytotoxic activity of T cell is enhanced significantly and tumor cell lysis is induced subsequently. Currently, various antibodies against PD-1 and programmed death-ligand 1 (PD-L1) are under clinical studies in lymphomas. In this review, we outline the rationale for investigation of PD-1-PD-L1 immune-checkpoint blockade in lymphomas and discuss their prospect of applications in clinical treatment.

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Funding

This work was supported by grants 81670104 and 81570201 from the National Natural Science Foundation of China (NSFC).

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  1. Yi Wang and Ling Wu contributed equally to this work.

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  1. National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin’s Clinical Research Center for Cancer, Tianjin Medical University Cancer Institute and Hospital, Tianjin, 300060, China

    Yi Wang, Ling Wu, Chen Tian & Yizhuo Zhang

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Y. W. and L. W. drafted the paper. C. T. and Y. Z. critically revised the paper. All authors approved all versions including the final version and are responsible for the accuracy and integrity of all aspects of the manuscript.

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Correspondence to Chen Tian or Yizhuo Zhang.

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Wang, Y., Wu, L., Tian, C. et al. PD-1-PD-L1 immune-checkpoint blockade in malignant lymphomas. Ann Hematol 97, 229–237 (2018). https://doi.org/10.1007/s00277-017-3176-6

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