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Autologous stem cell transplantation (ASCT) in patients with mantle cell lymphoma: a retrospective study of the Spanish lymphoma group (GELTAMO)

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Abstract

Guidelines recommend autologous stem cell transplantation (ASCT) consolidation in first complete or partial response after regimens including rituximab (R) and high-dose AraC (HDAC), but its use beyond that response is questioned. We present a retrospective analysis of 268 patients with MCL who received ASCT. With a median follow-up for survival patients of 54 months, progression-free survival and overall survival for the whole series were 38 and 74 months, respectively, and for patients transplanted in first CR 49 and 97 months, respectively. Patients without CR before transplant were analyzed separately, those who achieved CR after transplantation had better PFS (48 vs 0.03 months, p < 0.001) and OS (92 vs 16 months, p < 0.001) than the remaining. In univariate analysis, first CR at transplant (p = 0.01) and prior rituximab (p = 0.02) were the variables associated with PFS. For OS, the same variables resulted significant (p = 0.03 and p < 0.001, respectively). In multivariate analysis, only the status at transplant (first CR) remained significant. This retrospective study concludes that ASCT consolidation in first CR induces high survival rates. In other stages of disease, the need of ASCT as consolidation may be questioned.

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References

  1. Zhou Y, Wang H, Fang W, Romaguer JE, Zhang Y, Delasalle KB et al (2008) Incidence trends of mantle cell lymphoma in the United States between 1992 and 2004. Cancer 113:791–798

    Article  PubMed  Google Scholar 

  2. Swerdlow SH, Campo E, Harris NL, Jaffe ES, Pileri SA, Stein H et al (2008) Mantle cell lymphoma. In “WHO classification of tumours of haematopoietic and lymphoid tissues”. 4th edition. Lyon. IARC Press:229–232

  3. Dreyling M, Hiddemann W (2009) Current treatment standards and emerging strategies in mantle cell lymphoma. Hematology Am Soc Hematol Educ Program:542–551

  4. Lefrère F, Delmer A, Suzan F, Levy V, Belanger C, Djabarri M et al (2002) Sequential chemotherapy by CHOP and DHAP regimens followed by high-dose therapy with stem cell transplantation induces a high rate of complete response and improves event-free survival in mantle cell lymphoma: a prospective study. Leukemia 16(4):587–593

    Article  PubMed  Google Scholar 

  5. Romaguera JE, Fayad L, Rodriguez MA, Broglio KR, Hagemeister FB, Pro B et al (2005) High rate of durable remissions after treatment of newly diagnosed aggressive mantle-cell lymphoma with rituximab plus hyper-CVAD alternating with rituximab plus high-dose methotrexate and cytarabine. J Clin Oncol 23(28):7013–7023

    Article  CAS  PubMed  Google Scholar 

  6. Geisler CH, Kolstad A, Laurell A, Andersen NS, Pedersen LB, Jerkeman M et al (2008) Long-term progression-free survival of mantle cell lymphoma after intensive front-line immunochemotherapy with in vivo-purged stem cell rescue: a nonrandomized phase 2 multicenter study by the Nordic lymphoma group. Blood 112(7):2687–2693

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  7. Hermine O, Hoster E, Walewski J, Bosly A, Stilgenbauer S, Thieblemont C et al Addition of high-dose cytarabine to immunochemotherapy before autologous stem-cell transplantation in patients aged 65 years or younger with mantle cell lymphoma (MCL younger): a radomised, open-label, phase 3 trial of the European mantle cell lymphoma network. Lancet 388(10044):565–575

  8. Cassaday RD, Guthrie KA, Budde EL, Thompson L, Till BG, Press OW et al (2013) Specific features identify patients with relapsed or refractory mantle cell lymphoma benefitting from autologous hematopoietic cell transplantation. Biol Blood Marrow Transplant 19:1403–1406

    Article  PubMed  PubMed Central  Google Scholar 

  9. Vanderbergue E, Ruiz de Elvira C, Loberiza FR, Conde E, López-Guillermo A, Gisselbrecht C et al (2003) Outcome of autologous transplantation for mantle cell lymphoma: a study by the European blood and bone marrow transplant and autologous blood and marrow transplant registries. Br J Haematol 120(5):793–800

    Article  Google Scholar 

  10. Cheson BD, Horning SJ, Coiffier B, Shipp MA, Fisher RI, Connors JM et al (1999) Report of an international workshop to standardize response criteria for non-Hodgkin's lymphomas. NCI sponsored international working group. J Clin Oncol 17(4):1244

    Article  CAS  PubMed  Google Scholar 

  11. Kaplan EL, Meier P (1958) Nonparametric estimation from incomplete observations. J Am Statist Assoc 53:457–481

    Article  Google Scholar 

  12. Dreyling M, Geisler C, Hermine O, Kluin-Nelemans HC, Le Gouill S, Rule S et al (2014) Newly diagnosed and relapsed mantle cell lymphoma: ESMO clinical practice guidelines for diagnosis, treatment and follow-up. Ann Oncol 25(Suppl 3):iii83–iii92 10

    Article  PubMed  Google Scholar 

  13. Caballero D, Campo E, López-Guillermo A, Martín A, Arranz-Sáez R, Giné E et al (2013 Sep) Clinical practice guidelines for diagnosis, treatment and follow-up of patients with mantle cell lymphoma. Recommendations from the GEL/TAMO Spanish cooperative group. Ann Hematol 92(9):1151–1179

    Article  PubMed  Google Scholar 

  14. Robinson S, Dreger P, Caballero D, Corradini P, Geisler C, Ghielmini M et al (2015) The EBMT/EMCL consensus project on the role of autologous and allogeneic stem cell transplantation in mantle cell lymphoma. Leukemia 29(2):464–473

    Article  CAS  PubMed  Google Scholar 

  15. Vose JM, Bierman PJ, Weisenburger DD, Lynch JC, Bociek Y, Chan WC et al (2000) Autologous hematopoietic stem cell transplantation for mantle cell lymphoma. Biol Blood Marrow Transplant 6(6):640–645

    Article  CAS  PubMed  Google Scholar 

  16. Fenske TS, Zhang MJ, Carreras J, Ayala E, Burns LJ, Cashen A et al (2014) Autologous or reduced-intensity conditioning allogeneic hematopoietic cell transplantation for chemotherapy-sensitive mantle-cell lymphoma: analysis of transplantation timing and modality. J Clin Oncol 1;32(4):273–281

    Article  Google Scholar 

  17. Abrahamsson A, Albertsson-Lindblad A, Brown PN et al (2014) Real world data on primary treatment for mantle cell lymphoma: a Nordic lymphoma group observational study. Blood 21;124(8):1288–1295

    Article  Google Scholar 

  18. Wang ML, Lee H, Chuang H, Wagner-Bartak N, Hagemeister F, Westin J et al (2016) Ibrutinib in combination with rituximab in relapsed or refractory mantle cell lymphoma: a single-centre, open-label, phase 2 trial. Lancet Oncol 17(1):48–56

    Article  CAS  PubMed  Google Scholar 

  19. Visco C, Finotto S, Zambello R, Paolini R, Menin A, Zanotti R et al (2013) Combination of rituximab, bendamustine, and cytarabine for patients with mantle-cell non-Hodgkin lymphoma ineligible for intensive regimens or autologous transplantation. J Clin Oncol 31(11):1442–1449

    Article  CAS  PubMed  Google Scholar 

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Authors and Affiliations

  1. Hospital Universitario La Princesa, Diego de Leon, 62, 28006, Madrid, Spain

    A. García-Noblejas, J. Cannata-Ortiz & R. Arranz

  2. HU Marqués de Valdecilla, Santander, Spain

    E. Conde & S. González de Villambrosia

  3. Instituto Catalán de Oncología, Barcelona, Spain

    E. González Barca & S. Mercadal

  4. HU Clínico de Salamanca, Salamanca, Spain

    N. Gutiérrez & A. Martín García-Sancho

  5. HU Reina Sofía, Córdoba, Spain

    R. Rojas

  6. HU Donostia, Donostia, Spain

    M.J. Vidal

  7. H General de Jerez, Jerez, Mexico

    M.J. Ramírez

  8. HU 12 de Octubre, Madrid, Spain

    A. Jiménez-Ubieto

  9. HU Cruces, Madrid, Spain

    J.C. García-Ruiz

  10. H. Germans Trias i Pujol, Barcelona, Spain

    J. M. Sancho

  11. HU Vall d’Hebron, Barcelona, Spain

    A. López

  12. HU Nuestra Señora de la Candelaria, Santa Cruz de Tenerife, Spain

    P. Ríos Rull

  13. HU San Pablo, Madrid, Spain

    S. Novelli

  14. H Xeral-Cíes, Madrid, Spain

    C. Albo

  15. HU A Coruña, Coruña, Spain

    G. Debén

  16. HU Clínico Barcelona, Barcelona, Spain

    A. López-Guillermo

  17. HU Central de Asturias, Oviedo, Spain

    C. Nicolás

Authors
  1. A. García-Noblejas
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  2. J. Cannata-Ortiz
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  3. E. Conde
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  4. E. González Barca
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  5. N. Gutiérrez
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  6. R. Rojas
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  7. M.J. Vidal
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  8. M.J. Ramírez
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  9. A. Jiménez-Ubieto
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  10. J.C. García-Ruiz
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  11. J. M. Sancho
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  12. A. López
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  13. P. Ríos Rull
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  14. S. Novelli
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  15. C. Albo
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  16. G. Debén
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  17. A. López-Guillermo
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  18. C. Nicolás
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  19. S. González de Villambrosia
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  20. S. Mercadal
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  21. A. Martín García-Sancho
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  22. R. Arranz
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Contributions

AGN, JCO, and RA: designed the study, analyzed the data, and wrote the paper. AM: contributed to the design of the study and interpretation of data. All authors contributed to recruitment of patients, acquisition of data, and critical revision of the manuscript. All authors approved the final version of the paper to be published.

Corresponding author

Correspondence to R. Arranz.

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The authors declare no conflict of interest.

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García-Noblejas, A., Cannata-Ortiz, J., Conde, E. et al. Autologous stem cell transplantation (ASCT) in patients with mantle cell lymphoma: a retrospective study of the Spanish lymphoma group (GELTAMO). Ann Hematol 96, 1323–1330 (2017). https://doi.org/10.1007/s00277-017-2998-6

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  • DOI: https://doi.org/10.1007/s00277-017-2998-6

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