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Autologous stem cell transplantation with busulfan, cyclophosphamide, and etoposide as an intensifying frontline treatment in patients with peripheral T cell lymphomas: a multicenter retrospective trial

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Abstract

The effectiveness of high-dose chemotherapy (HDT) followed by autologous stem cell transplantation (ASCT) as a frontline treatment in peripheral T cell lymphomas (PTCLs) is still unclear. We retrospectively investigated the clinical outcomes of HDT/ASCT as an intensifying frontline treatment in 31 patients with newly diagnosed PTCLs. The conditioning regimen of HDT/ASCT consisted of busulfan, cyclophosphamide, and etoposide (BuCyE). At diagnosis, five (16.1 %) patients were classified as high risk according to the prognostic index for PTCL (PIT). The disease status of the patients before HDT/ASCT consisted of 23 patients (74.2 %) with complete response (CR) and eight patients (25.8 %) with partial response (PR). Six (75 %) out of eight patients with PR at pretransplantation were improved in terms of the response to CR after HDT/ASCT. At a median follow-up of 32.4 months, the 3-year probability of overall survival (OS) and progression-free survival (PFS) was 64.5 ± 8.6 %. Transplant-related mortality occurred in three patients (9.7 %), due to septic shock, hemorrhage, and delayed pneumonia, respectively. Bone marrow involvement of PTCL at diagnosis was a poor prognostic factor for OS. In conclusion, frontline HDT/ASCT with a conditioning regimen of BuCyE may be an effective and tolerable intensifying therapeutic option to improve outcomes in patients with PTCLs.

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The authors declare that they have no conflict of interest.

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Authors and Affiliations

  1. Department of Hematology-Oncology, Chonnam National University Hwasun Hospital, 322 Seoyangro, Hwasun, Jeollanamdo, 519-763, Republic of Korea

    Jae-Sook Ahn, Deok-Hwan Yang, Sung-Hoon Jung, Yeo-Kyeoung Kim, Hyeoung-Joon Kim & Je-Jung Lee

  2. Kyungpook National University Hospital, Daegu, Republic of Korea

    Yee Soo Chae & Sang Kyun Sohn

  3. Chonbuk National University Hospital, Jeonju, Jeollabukdo, Republic of Korea

    Ho-Young Yhim & Jae-Yong Kwak

  4. Korea University College of Medicine, Seoul, Republic of Korea

    Se-Ryeon Lee

  5. The Brain Korea 21 Project, Center for Biomedical Human Resources at Chonnam National University, Gwangju, Republic of Korea

    Je-Jung Lee

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  1. Jae-Sook Ahn
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Correspondence to Je-Jung Lee.

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Jae-Sook Ahn and Deok-Hwan Yang contributed equally to this work.

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Ahn, JS., Yang, DH., Jung, SH. et al. Autologous stem cell transplantation with busulfan, cyclophosphamide, and etoposide as an intensifying frontline treatment in patients with peripheral T cell lymphomas: a multicenter retrospective trial. Ann Hematol 92, 789–797 (2013). https://doi.org/10.1007/s00277-013-1685-5

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  • DOI: https://doi.org/10.1007/s00277-013-1685-5

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