Abstract
Purpose
To report the safety and diagnostic performance of magnetic resonance (MRI)—guided core biopsy of osseous lesions in children with chronic recurrent multifocal osteomyelitis (CRMO) that were visible on MRI but were occult on radiography and computed tomography (CT).
Materials and Methods
A retrospective analysis of MRI-guided osseous biopsy performed in seven children (four girls and three boys; mean age 13 years (range 11 to 14) with CRMO was performed. Indication for using MRI guidance was visibility of lesions by MRI only. MRI-guided procedures were performed with 0.2-Tesla (Magnetom Concerto; Siemens, Erlangen, Germany; n = 5) or 1.5-T (Magnetom Espree; Siemens; n = 2) open MRI systems. Core needle biopsy was obtained using an MRI-compatible 4-mm drill system. Conscious sedation or general anesthesia was used. Parameters evaluated were lesion visibility, technical success, procedure time, complications and microbiology, cytology, and histopathology findings.
Results
Seven of seven (100%) targeted lesions were successfully visualized and sampled. All obtained specimens were sufficient for histopathological analysis. Length of time of the procedures was 77 min (range 64 to 107). No complications occurred. Histopathology showed no evidence of malignancy, which was confirmed at mean follow-up of 50 months (range 28 to 78). Chronic nonspecific inflammation characteristic for CRMO was present in four of seven (58%) patients, and edema with no inflammatory cells was found in three of seven (42%) patients. There was no evidence of infection in any patient.
Conclusion
MRI-guided osseous biopsy is a safe and accurate technique for the diagnosis of pediatric CRMO lesions that are visible on MRI only.
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References
Huber AM, Lam PY, Duffy CM et al (2002) Chronic recurrent multifocal osteomyelitis: clinical outcomes after more than five years of follow-up. J Pediatr 141:198–203
Fritz J, Tzaribatchev N, Claussen CD, Carrino JA, Horger MS (2009) Chronic recurrent multifocal osteomyelitis: comparison of whole-body MR imaging with radiography and correlation with clinical and laboratory data. Radiology 252:842–851
Girschick HJ, Raab P, Surbaum S et al (2005) Chronic nonbacterial osteomyelitis in children. Ann Rheum Dis 64:279–285
Jurik AG (2004) Chronic recurrent multifocal osteomyelitis. Semin Musculoskelet Radiol 8:243–253
Khanna G, Sato TS, Ferguson P (2009) Imaging of chronic recurrent multifocal osteomyelitis. Radiographics 29:1159–1177
Golla A, Jansson A, Ramser J et al (2002) Chronic recurrent multifocal osteomyelitis (CRMO): evidence for a susceptibility gene located on chromosome 18q21.3–18q22. Eur J Hum Genet 10:217–221
Girschick HJ, Mornet E, Beer M, Warmuth-Metz M, Schneider P (2007) Chronic multifocal nonbacterial osteomyelitis in hypophosphatasia mimicking malignancy. BMC Pediatr 7:3
Duffy CM, Lam PY, Ditchfield M, Allen R, Graham HK (2002) Chronic recurrent multifocal osteomyelitis: review of orthopaedic complications at maturity. J Pediatr Orthop 22:501–505
Job-Deslandre C, Krebs S, Kahan A (2001) Chronic recurrent multifocal osteomyelitis: five-year outcomes in 14 pediatric cases. Joint Bone Spine 68:245–251
Girschick HJ, Huppertz HI, Harmsen D, Krauspe R, Muller-Hermelink HK, Papadopoulos T (1999) Chronic recurrent multifocal osteomyelitis in children: diagnostic value of histopathology and microbial testing. Hum Pathol 30:59–65
Carrino JA, Khurana B, Ready JE, Silverman SG, Winalski CS (2007) Magnetic resonance imaging-guided percutaneous biopsy of musculoskeletal lesions. J Bone Joint Surg Am 89:2179–2187
Streitparth F, Gebauer B, Melcher I et al (2009) MR-guided laser ablation of osteoid osteoma in an open high-field system (1.0 T). Cardiovasc Intervent Radiol 32:320–325
Seebauer CJ, Bail HJ, Rump JC, Walter T, Teichgraber UK (2010) Advancements in orthopedic intervention: retrograde drilling and bone grafting of osteochondral lesions of the knee using magnetic resonance imaging guidance. Cardiovasc Intervent Radiol 33:1230–1234
Wonneberger U, Schnackenburg B, Streitparth F, Walter T, Rump J, Teichgraber UK (2010) Evaluation of magnetic resonance imaging-compatible needles and interactive sequences for musculoskeletal interventions using an open high-field magnetic resonance imaging scanner. Cardiovasc Intervent Radiol 33:346–351
Fritz J, Thomas C, Tzaribachev N et al (2009) MRI-guided injection procedures of the temporomandibular joints in children and adults: technique, accuracy, and safety. AJR Am J Roentgenol 193:1148–1154
Ojala R, Sequeiros RB, Klemola R, Vahala E, Jyrkinen L, Tervonen O (2002) MR-guided bone biopsy: preliminary report of a new guiding method. J Magn Reson Imaging 15:82–86
Blanco SR, Klemola R, Ojala R et al (2002) MRI-guided trephine biopsy and fine-needle aspiration in the diagnosis of bone lesions in low-field (0.23 T) MRI system using optical instrument tracking. Eur Radiol 12:830–835
Koenig CW, Duda SH, Truebenbach J et al (2001) MR-guided biopsy of musculoskeletal lesions in a low-field system. J Magn Reson Imaging 13:761–768
Lewin JS, Petersilge CA, Hatem SF et al (1998) Interactive MR imaging-guided biopsy and aspiration with a modified clinical C-arm system. AJR Am J Roentgenol 170:1593–1601
Gamble JG, Rinsky LA (1986) Chronic recurrent multifocal osteomyelitis: a distinct clinical entity. J Pediatr Orthop 6:579–584
Manson D, Wilmot DM, King S, Laxer RM (1989) Physeal involvement in chronic recurrent multifocal osteomyelitis. Pediatr Radiol 20:76–79
Fritz J, Henes JC, Thomas C et al (2008) Diagnostic and interventional MRI of the sacroiliac joints using a 1.5-T open-bore magnet: a one-stop-shopping approach. AJR Am J Roentgenol 191:1717–1724
Konig CW, Trubenbach J, Bohm P, Fritz J, Duda SH, Pereira PL (2003) Magnetic resonance-guided transcortical biopsy of bone marrow lesions using a magnetic resonance imaging-compatible piezoelectric power drill: preliminary experience. Invest Radiol 38:159–163
Thomas C, Springer F, Rothke M et al (2010) In vitro assessment of needle artifacts with an interactive three-dimensional MR fluoroscopy system. J Vasc Interv Radiol 21:375–380
Jurik AG, Egund N (1997) MRI in chronic recurrent multifocal osteomyelitis. Skeletal Radiol 26:230–238
Jurriaans E, Singh NP, Finlay K, Friedman L (2001) Imaging of chronic recurrent multifocal osteomyelitis. Radiol Clin North Am 39:305–327
Fritz J, Pereira PL (2007) MR-Guided pain therapy: principles and clinical applications. Rofo 179:914–924
Conflict of interest
J. A. Carrino holds research grants from Siemens AG and Carestream Health, Inc., and is a research consultant for General Electric Company. However, he has no commercial interest in these companies.
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Fritz, J., Tzaribachev, N., Thomas, C. et al. Magnetic Resonance Imaging-Guided Osseous Biopsy in Children With Chronic Recurrent Multifocal Osteomyelitis. Cardiovasc Intervent Radiol 35, 146–153 (2012). https://doi.org/10.1007/s00270-011-0119-9
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DOI: https://doi.org/10.1007/s00270-011-0119-9