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Comparative Evaluation of the Biodegradability and Wrinkle Reduction Efficacy of Human-Derived Collagen Filler and Hyaluronic Acid Filler

  • Original Article
  • Basic Science/Experimental
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Abstract

Background

The development of fillers for wrinkle prevention is growing to meet rising demands to reduce the aging of skin.

Objective

In this experiment, we confirmed the effects of human collagen and hyaluronic acid filler biodegradation for wrinkle reduction using a photo-aging mouse model.

Materials and Methods

A total of 10 hairless mice (SKH1-Hrhr) were randomly divided into two groups and injected with hyaluronic acid and human-derived collagen filler. At 0, 2, 4, 8, and 12 weeks, PRIMOSlite®, folliscope, and MRI were used to evaluate the biodegradability of the fillers after the injections. We also studied the photo-aging mouse model for skin roughness and histological evaluation and confirmed that the filler injection had excellent anti-wrinkle effects.

Results

Human-derived collagen fillers had excellent biodegradability compared to that of hyaluronic acid fillers. The skin surface roughness in the photo-aging mouse models was significantly reduced after injections of human-derived collagen filler.

Conclusion

Our results showed that the human-derived collagen filler had excellent biodegradability and effectively reduced wrinkle formation in a photo-aging mouse model.

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References

  1. Marinelli E, Montanari Vergallo G, Reale G et al (2016) The role of fillers in aesthetic medicine: medico-legal aspects. Eur Rev Med Pharmacol Sci 20:4628–4634

    CAS  PubMed  Google Scholar 

  2. Curcio NM, Parish LC (2009) Injectable fillers: an American perspective. G Ital Dermatol Venereol 144:271–279

    CAS  PubMed  Google Scholar 

  3. Sclafani AP, Romo T 3rd (2001) Collagen, human collagen, and fat: the search for a three-dimensional soft tissue filler. Facial Plast Surg 17:79–85

    Article  CAS  Google Scholar 

  4. Lovell CR, Smolenski KA, Duance VC et al (1987) Type I and III collagen content and fibre distribution in normal human skin during ageing. Br J Dermatol 117:419–428

    Article  CAS  Google Scholar 

  5. Fisher GJ, Wang ZQ, Datta SC et al (1997) Pathophysiology of premature skin aging induced by ultraviolet light. N Engl J Med 337:1419–1428

    Article  CAS  Google Scholar 

  6. Bauman L (2004) CosmoDerm/CosmoPlast (human bioengineered collagen) for the aging face. Facial Plast Surg 20:125–128

    Article  Google Scholar 

  7. Gold MH, Sadick NS (2018) Optimizing outcomes with polymethylmethacrylate fillers. J Cosmet Dermatol 17:298–304

    Article  Google Scholar 

  8. Eppley BL, Dadvand B (2006) Injectable soft-tissue fillers: clinical overview. Plast Reconstr Surg 118:98e–106e

    Article  Google Scholar 

  9. Jeong JH, Fan Y, You GY, Choi TH, Kim S (2015) Improvement of photoaged skin wrinkles with cultured human fibroblasts and adipose-derived stem cells: a comparative study. J Plast Reconstr Aesthet Surg 68:372–381

    Article  Google Scholar 

  10. Altman AM, Abdul Khalek FJ, Seidensticker M et al (2010) Human tissue-resident stem cells combined with hyaluronic acid gel provide fibrovascular-integrated soft-tissue augmentation in a murine photoaged skin model. Plast Reconstr Surg 125:63–73

    Article  CAS  Google Scholar 

  11. Pustisek N, Situm M (2011) UV-radiation, apoptosis and skin. Coll Antropol 35(Suppl 2):339–341

    PubMed  Google Scholar 

  12. Darwiche N, Bazzi H, El-Touni L et al (2005) Regulation of ultraviolet B radiation-mediated activation of AP1 signaling by retinoids in primary keratinocytes. Radiat Res 163:296–306

    Article  CAS  Google Scholar 

  13. Moon SH, Lee YJ, Rhie JW et al (2015) Comparative study of the effectiveness and safety of porcine and bovine atelocollagen in Asian nasolabial fold correction. J Plast Surg Hand Surg 49:147–152

    Article  Google Scholar 

  14. Baumann L (2004) Dermal fillers. J Cosmet Dermatol 3:249–250

    Article  Google Scholar 

  15. Narins RS, Bowman PH (2005) Injectable skin fillers. Clin Plast Surg 32:151–162

    Article  Google Scholar 

  16. Arsiwala SZ (2010) Safety and persistence of non-animal stabilized hyaluronic acid fillers for nasolabial folds correction in 30 Indian patients. J Cutan Aesthet Surg 3:156–161

    Article  Google Scholar 

  17. Fagien S (2000) Facial soft-tissue augmentation with injectable autologous and allogeneic human tissue collagen matrix (autologen and dermalogen). Plast Reconstr Surg 105:362–373 ; discussion 74-5

    Article  CAS  Google Scholar 

  18. Cohen SR, Holmes RE (2004) Artecoll: a long-lasting injectable wrinkle filler material: report of a controlled, randomized, multicenter clinical trial of 251 subjects. Plast Reconstr Surg 114:964–976 ; discussion 77-9

    Article  Google Scholar 

  19. Sclafani AP, Romo T 3rd, Parker A et al (2002) Homologous collagen dispersion (dermalogen) as a dermal filler: persistence and histology compared with bovine collagen. Ann Plast Surg 49:181–188

    Article  Google Scholar 

  20. Gensanne D, Josse G, Schmitt AM, Lagarde JM, Vincensini D (2007) In vivo visualization of hyaluronic acid injection by high spatial resolution T2 parametric magnetic resonance images. Skin Res Technol 13:385–389

    Article  CAS  Google Scholar 

  21. La Gatta A, Papa A, Schiraldi C, De Rosa M (2016) Hyaluronan dermal fillers via crosslinking with 1,4-butandiol diglycidyl ether: exploitation of heterogeneous reaction conditions. J Biomed Mater Res B Appl Biomater 104:9–18

    Article  Google Scholar 

  22. Fan Y, Jeong JH, You GY et al (2015) An experimental model design for photoaging. J Craniofac Surg 26:e467–e471

    Article  Google Scholar 

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Correspondence to Beom Joon Kim.

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The authors declare that they have no conflicts of interest to disclose.

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All applicable institutional and/or national guidelines for the care and use of animals were followed.

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Jong Hwan Kim, Tae-Rin Kwon and Sung Woo Hong have contributed equally to this study.

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Kim, J.H., Kwon, TR., Hong, S.W. et al. Comparative Evaluation of the Biodegradability and Wrinkle Reduction Efficacy of Human-Derived Collagen Filler and Hyaluronic Acid Filler. Aesth Plast Surg 43, 1095–1101 (2019). https://doi.org/10.1007/s00266-019-01373-x

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