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Anaplastic Large-Cell Lymphoma Associated with Breast Implants: A Case Report of a Transgender Female

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  • Breast Surgery
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Abstract

Breast implant-associated anaplastic large-cell lymphoma (BIA-ALCL) is a rare peripheral T cell lymphoma. BIA-ALCL is a disease of the fibrous capsule surrounding the implant and occurs in patients after both breast reconstruction and augmentation. More than 300 cases have been reported so far, including two in a transgender patient. Here we describe BIA-ALCL presented with a mass in a transgender patient and the first case of BIA-ALCL in the Czech Republic. In 2007, a 33-year-old transgender male to female underwent bilateral breast augmentation as a part of his transformation to female. In June 2014, the patient developed a 5-cm tumorous mass in her left breast. Magnetic resonance imaging of the chest revealed a ruptured implant and a tumorous mass penetrating into the capsule and infiltrating the pectoral muscle. An R0 surgery was indicated—the implant, silicone gel and capsule were removed, and the tumorous mass was resected together with a part of the pectoral muscle. Histology revealed anaplastic large-cell lymphoma. The patient underwent standard staging procedures for lymphoma including a bone marrow trephine biopsy, which confirmed stage IE. The patient was treated with the standard chemotherapy for systemic ALCL—6 cycles of CHOP-21. The patient was tumor-free at the 2-year follow-up. BIA-ALCL has been reported mostly in women who received implants for either reconstructive or aesthetic augmentation. This is the third report of BIA-ALCL in a transgender person, the first in the Czech Republic.

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Acknowledgments

This work was supported by the Charles University Center of Excellence grant UNCE 20402, by the Ministry of Education, Youth and Sports Institutional Support for Long-term Development of Research Organizations PROGRES Q26/LF1 and PROGRES Q28/LF1 and by Grant Agency of Charles University GAUK 130717.

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Authors and Affiliations

  1. Department of Plastic Surgery, Royal Vinohrady Teaching Hospital, Srobarova 1150/50, 100 34, Prague, Czech Republic

    Matej Patzelt, Lucie Zarubova, Adrianna Brandejsova & Andrej Sukop

  2. Third Faculty of Medicine, Charles University, Ruska 87, 100 00, Prague, Czech Republic

    Matej Patzelt, Robert Gürlich & Andrej Sukop

  3. Department of General Surgery, Royal Vinohrady Teaching Hospital, Srobarova 1150/50, 100 34, Prague, Czech Republic

    Lucie Zarubova & Robert Gürlich

  4. First Medical Department of Hematology, Charles University General, U Nemocnice 499/2, 128 08, Prague, Czech Republic

    Pavel Klener & Marek Trneny

  5. Institute of Pathological Physiology, First Faculty of Medicine, Charles University, Katerinska 32, 121 08, Prague, Czech Republic

    Pavel Klener

  6. Department of Radiology, Royal Vinohrady Teaching Hospital, Srobarova 1150/50, 100 34, Prague, Czech Republic

    Josef Barta

  7. Department of Pathology in Prague, AeskuLab Pathology, Evropska 2589/33b, 100 06, Prague, Czech Republic

    Kamila Benkova

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  1. Matej Patzelt
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  2. Lucie Zarubova
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Correspondence to Lucie Zarubova.

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Patzelt, M., Zarubova, L., Klener, P. et al. Anaplastic Large-Cell Lymphoma Associated with Breast Implants: A Case Report of a Transgender Female. Aesth Plast Surg 42, 451–455 (2018). https://doi.org/10.1007/s00266-017-1012-y

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  • DOI: https://doi.org/10.1007/s00266-017-1012-y

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