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Time Spent Before the Mast: An Emerging Role for Mast Cells in Prosthetic Breast Implant Capsule Formation

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References

  1. Brazin J, Malliaris S, Groh B, Hidalgo D, Otterburn D, Mehrara B, Silver RB, Spector JA: Mast cells in the periprosthetic breast capsule. J Aesth Surg. doi:10.1007/s00266-014-0318-2

  2. Quintin J, Cheng SC, van der Meer JW, Netea MG (2014) Innate immune memory: towards a better understanding of host defense mechanisms. Curr Opin Immunol 29C:1–7

    Article  PubMed  Google Scholar 

  3. Banchereau J, Steinman RM (1998) Dendritic cells and the control of immunity. Nature 392:245–252

    Article  CAS  PubMed  Google Scholar 

  4. Wolfram D1, Rainer C, Niederegger H, Piza H, Wick G (2004) Cellular and molecular composition of fibrous capsules formed around silicone breast implants with special focus on local immune reactions. J Autoimmun 23:81–91

  5. Prantl L1, Pöppl N, Horvat N, Heine N, Eisenmann-Klein M (2005) Serologic and histologic findings in patients with capsular contracture after breast augmentation with smooth silicone gel implants: Is serum hyaluronan a potential predictor? Aesthetic Plast Surg 29:510–518

  6. Mosser DM, Edwards JP (2008) Exploring the full spectrum of macrophage activation. Nat Rev Immunol 8:958–969

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  7. Hsieh CH1, Sun CK, Lu TH, Chen YC, Lin CJ, Wu CJ, Rau CS, Jeng SF (2011) Simvastatin induces heme oxygenase-1 expression but fails to reduce inflammation in the capsule surrounding a silicone shell implant in rats. J Surg Res 168:272–280

  8. van Rooijen N (1992) Liposome-mediated elimination of macrophages. Res Immunol 143:215–219

    Article  PubMed  Google Scholar 

  9. Jung S, Unutmaz D, Wong P, Sano G, De Los Santos K, Sparwasser T et al (2002) In vivo depletion of CD11c(+) dendritic cells abrogates priming of CD8(+) T cells by exogenous cell-associated antigens. Immunity 17:211–220

    Article  CAS  PubMed Central  PubMed  Google Scholar 

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Acknowledgments

Support for this work was provided by 1RO1HL108954-01 and 1R01HL112914-01A1, and from the Vascular Medicine Institute, the Institute for Transfusion Medicine and the Hemophilia Center of Western Pennsylvania.

Conflict of interest

Jeffrey S. Isenberg is Chair of the Scientific Advisory Boards of Vasculox, Inc. and Radiation Control Technologies, Inc. and holds equity interest in these organizations.

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Authors and Affiliations

  1. Vascular Medicine Institute, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, 15261, USA

    Jeffrey S. Isenberg

  2. E1258, BST, Division of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, University of Pittsburgh School of Medicine, 200 Lothrop Street, Pittsburgh, PA, 15261, USA

    Jeffrey S. Isenberg

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  1. Jeffrey S. Isenberg
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Correspondence to Jeffrey S. Isenberg.

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Isenberg, J.S. Time Spent Before the Mast: An Emerging Role for Mast Cells in Prosthetic Breast Implant Capsule Formation. Aesth Plast Surg 38, 815–816 (2014). https://doi.org/10.1007/s00266-014-0327-1

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  • DOI: https://doi.org/10.1007/s00266-014-0327-1

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