Skip to main content

Advertisement

Log in

Fournier gangrene: pictorial review

  • Review
  • Published:
Abdominal Radiology Aims and scope Submit manuscript

Abstract

Fournier gangrene is an emergency condition that is associated with a high mortality rate. It is defined as a rapidly progressing infective necrotizing fasciitis of the perineal, perianal, and genital regions. Early diagnosis, broad-spectrum antibiotic coverage, and adequate surgical debridement are crucial and lead to better prognosis and patient survival. There is increasing utilization of computed tomography (CT) in the initial evaluation of Fournier gangrene. CT can confirm the diagnosis in equivocal cases, determine the source of infection, and evaluate the disease extent. In this pictorial review, we discuss the pathogenesis of Fournier gangrene and display the imaging spectrum with an emphasis on CT findings, including asymmetrical fascial thickening, soft tissue stranding, soft tissue gas, collection, and abscess formation. The infection originating from colorectal pathology, the affected anatomy, and the involvement of the abdominal wall are important predictors of mortality. The familiarity of the varied imaging appearance of Fournier gangrene is necessary to provide an accurate diagnosis, and evaluation of disease extent is crucial for optimal surgical debridement.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3
Fig. 4
Fig. 5
Fig. 6
Fig. 7
Fig. 8
Fig. 9
Fig. 10
Fig. 11
Fig. 12
Fig. 13
Fig. 14
Fig. 15
Fig. 16
Fig. 17

Similar content being viewed by others

References

  1. Eke N (2000) Fournier’s gangrene: a review of 1726 cases. Br J Surg 87:718-728.

  2. Gurdal M, Yucebas E, Tekin A, Beysel M, Aslan R, Sengor F (2003) Predisposing factors and treatment outcome in Fournier’s gangrene. Analysis of 28 cases. Urol Int 70:286-290.

  3. Fournier JA (1988) Jean-Alfred Fournier 1832-1914. Gangrene foudroyante de la verge (overwhelming gangrene). Sem Med 1883. Dis Colon Rectum 31:984-988.

  4. Safioleas M, Stamatakos M, Mouzopoulos G, Diab A, Kontzoglou K, Papachristodoulou A (2006) Fournier’s gangrene: exists and it is still lethal. Int Urol Nephrol 38:653-657.

  5. Ioannidis O, Kitsikosta L, Tatsis D, Skandalos I, Cheva A, Gkioti A, Varnalidis I, Symeonidis S, Savvala NA, Parpoudi S, Paraskevas GK, Pramateftakis MG, Kotidis E, Mantzoros I, Tsalis KG (2017) Fournier’s Gangrene: Lessons Learned from Multimodal and Multidisciplinary Management of Perineal Necrotizing Fasciitis. Front Surg 4:36.

  6. Sorensen MD, Krieger JN (2016) Fournier’s Gangrene: Epidemiology and Outcomes in the General US Population. Urol Int 97:249-259.

  7. Levenson RB, Singh AK, Novelline RA (2008) Fournier gangrene: role of imaging. Radiographics 28:519-528.

  8. Moussa M, Abou Chakra M (2019) Isolated Penile Fournier’s gangrene: A case report and literature review. Int J Surg Case Rep 62:65-68.

  9. Bersoff-Matcha SJ, Chamberlain C, Cao C, Kortepeter C, Chong WH (2019) Fournier Gangrene Associated With Sodium-Glucose Cotransporter-2 Inhibitors: A Review of Spontaneous Postmarketing Cases. Ann Intern Med 170:764-769.

  10. Drug safety communications: FDA warns about rare occurrences of a serious infection of the genital area with SGLT2 inhibitors for diabetes (2018) Available from: https://www.fda.gov/drugs/drug-safety-and-availability/fda-warns-about-rare-occurrences-serious-infection-genital-area-sglt2-inhibitors-diabetes. Accessed 4 February 2020.

  11. Smith GL, Bunker CB, Dinneen MD (1998) Fournier’s gangrene. Br J Urol 81:347-355.

  12. Uppot RN, Levy HM, Patel PH (2003) Case 54: Fournier gangrene. Radiology 226:115-117.

  13. Mallikarjuna MN, Vijayakumar A, Patil VS, Shivswamy BS (2012) Fournier’s Gangrene: Current Practices. ISRN Surg 2012:942437.

  14. Lin MP, Chen YL, Cheng JT, Lu CL (2018) Early signs of Fournier gangrene: radiological characteristics. Radiol Diagn Imaging 2:1-6.

  15. Rajan DK, Scharer KA (1998) Radiology of Fournier’s gangrene. AJR Am J Roentgenol 170:163-168.

  16. Wroblewska M, Kuzaka B, Borkowski T, Kuzaka P, Kawecki D, Radziszewski P (2014) Fournier’s gangrene–current concepts. Pol J Microbiol 63:267-273.

  17. Thwaini A, Khan A, Malik A, Cherian J, Barua J, Shergill I, Mammen K (2006) Fournier’s gangrene and its emergency management. Postgrad Med J 82:516-519.

  18. Rosenberg PH, Shuck JM, Tempest BD, Reed WP (1978) Diagnosis and thereapy of necrotizing soft tissue infections of the perineum. Ann Surg 187:430-434.

  19. Gerber GS, Guss SP, Pielet RW (1994) Fournier’s gangrene secondary to intra-abdominal processes. Urology 44:779-782.

  20. Paty R, Smith AD (1992) Gangrene and Fournier’s gangrene. Urol Clin North Am 19:149-162.

  21. Czymek R, Hildebrand P, Kleemann M, Roblick U, Hoffmann M, Jungbluth T, Burk C, Bruch HP, Kujath P (2009) New insights into the epidemiology and etiology of Fournier’s gangrene: a review of 33 patients. Infection 37:306-312.

  22. Tahmaz L, Erdemir F, Kibar Y, Cosar A, Yalcyn O (2006) Fournier’s gangrene: report of thirty-three cases and a review of the literature. Int J Urol 13:960-967.

  23. Stephens BJ, Lathrop JC, Rice WT, Gruenberg JC (1993) Fournier’s gangrene: historic (1764-1978) versus contemporary (1979-1988) differences in etiology and clinical importance. Am Surg 59:149-154.

  24. Dahm P, Roland FH, Vaslef SN, Moon RE, Price DT, Georgiade GS, Vieweg J (2000) Outcome analysis in patients with primary necrotizing fasciitis of the male genitalia. Urology 56:31-35; discussion 35-36.

  25. Altarac S, Katusin D, Crnica S, Papes D, Rajkovic Z, Arslani N (2012) Fournier’s gangrene: etiology and outcome analysis of 41 patients. Urol Int 88:289-293.

  26. Yeniyol CO, Suelozgen T, Arslan M, Ayder AR (2004) Fournier’s gangrene: experience with 25 patients and use of Fournier’s gangrene severity index score. Urology 64:218-222.

  27. Benjelloun EB, Souiki T, Yakla N, Ousadden A, Mazaz K, Louchi A, Kanjaa N, Taleb KA (2013) Fournier’s gangrene: our experience with 50 patients and analysis of factors affecting mortality. World J Emerg Surg 8:13.

  28. Ruiz-Tovar J, Cordoba L, Devesa JM (2012) Prognostic factors in Fournier gangrene. Asian J Surg. 35:37-41.

  29. Martinschek A, Evers B, Lampl L, Gerngross H, Schmidt R, Sparwasser C (2012) Prognostic aspects, survival rate, and predisposing risk factors in patients with Fournier’s gangrene and necrotizing soft tissue infections: evaluation of clinical outcome of 55 patients. Urol Int 89:173-179.

  30. Kumar A, Stiles E. Perineal soft tissue infections. Seminars in Colon and Rectal Surgery. 2019;30(3):100692.

  31. Czymek R, Frank P, Limmer S, Schmidt A, Jungbluth T, Roblick U, Burk C, Bruch HP, Kujath P (2010) Fournier’s gangrene: is the female gender a risk factor? Langenbecks Arch Surg 395:173-180.

  32. Lynch CM, Pinelli DM, Cruse CW, Spellacy WN, Sinnott JT, Shashy RG (1997) Maternal death from postpartum necrotizing fasciitis arising in an episiotomy: a case report. Infect Dis Obstet Gynecol 5:341-344.

  33. Medhi R, Rai S, Das A, Ahmed M, Das B (2015) Necrotizing fasciitis - a rare complication following common obstetric operative procedures: report of two cases. Int J Womens Health 7:357-360.

  34. Amendola MA, Casillas J, Joseph R, Antun R, Galindez O (1994) Fournier’s gangrene: CT findings. Abdom Imaging 19:471-474.

  35. Ballard DH, Mazaheri P, Raptis CA, Lubner MG, Menias CO, Pickhardt PJ, Mellnick VM (2020) Fournier Gangrene in Men and Women: Appearance on CT, Ultrasound, and MRI and What the Surgeon Wants to Know. Can Assoc Radiol J 71:30-39.

  36. Fernando SM, Tran A, Cheng W, Rochwerg B, Kyeremanteng K, Seely AJE, Inaba K, Perry JJ (2019) Necrotizing Soft Tissue Infection: Diagnostic Accuracy of Physical Examination, Imaging, and LRINEC Score: A Systematic Review and Meta-Analysis. Ann Surg 269:58-65.

  37. Wysoki MG, Santora TA, Shah RM, Friedman AC (1997) Necrotizing fasciitis: CT characteristics. Radiology 203:859-863.

  38. Begley MG, Shawker TH, Robertson CN, Bock SN, Wei JP, Lotze MT (1988) Fournier gangrene: diagnosis with scrotal US. Radiology 169:387-389.

  39. Dogra VS, Smeltzer JS, Poblette J (1994) Sonographic diagnosis of Fournier’s gangrene. J Clin Ultrasound 22:571-572.

  40. Chennamsetty A, Khourdaji I, Burks F, Killinger KA (2015) Contemporary diagnosis and management of Fournier’s gangrene. Ther Adv Urol 7:203-215.

  41. Avery LL, Scheinfeld MH (2013) Imaging of penile and scrotal emergencies. Radiographics 33:721-740.

  42. Weimer SB, Matthews MR, Caruso DM, Foster KN (2017) Retroperitoneal Necrotizing Fasciitis from Fournier’s Gangrene in an Immunocompromised Patient. Case Rep Surg 2017:5290793.

  43. Sebastian-Valverde E, Pañella-Vilamú C, Membrilla-Fernández E, Sancho-Insenser JJ, Grande-Posa L (2015) Retroperitoneal necrotizing fasciitis secondary to Fournier’s gangrene. European Surgery 47:271-273.

  44. Fajdic J, Bukovic D, Hrgovic Z, Habek M, Gugic D, Jonas D, Fassbender WJ (2007) Management of Fournier’s gangrene–report of 7 cases and review of the literature. Eur J Med Res 12:169-172.

  45. Terzic M, Micic J, Maricic S, Arsenovic N (2009) [Recurrent Fournier’s gangrene in a diabetic patient]. Srp Arh Celok Lek 137:423-425.

  46. Dinc T, Kayilioglu SI, Sozen I, Yildiz BD, Coskun F (2014) Fournier’s Gangrene as a Postoperative Complication of Inguinal Hernia Repair. Case Rep Surg 2014:408217.

  47. Kickuth R, Adams S, Kirchner J, Pastor J, Simon S, Liermann D (2001) Magnetic resonance imaging in the diagnosis of Fournier’s gangrene. Eur Radiol 11:787-790.

  48. Michel F, Fauchery A, Belhadj M, Couailler JF, Martin-Champetier R (1997) [The contribution of imagery in the early diagnosis of Fournier’s gangrene]. Prog Urol 7:471-475.

  49. Chaudhry AA, Baker KS, Gould ES, Gupta R (2015) Necrotizing fasciitis and its mimics: what radiologists need to know. AJR Am J Roentgenol 204:128-139.

  50. Sharif HS, Clark DC, Aabed MY, Aideyan OA, Haddad MC, Mattsson TA (1990) MR imaging of thoracic and abdominal wall infections: comparison with other imaging procedures. AJR Am J Roentgenol 154:989-995.

  51. Yoneda A, Fujita F, Tokai H, Ito Y, Haraguchi M, Tajima Y, Kanematsu T (2010) MRI can determine the adequate area for debridement in the case of Fournier’s gangrene. Int Surg 95:76-79.

  52. Schmid MR, Kossmann T, Duewell S. Differentiation of necrotizing fasciitis and cellulitis using MR imaging (1998) AJR Am J Roentgenol 170:615-620.

Download references

Funding

Not applicable.

Author information

Authors and Affiliations

Authors

Contributions

SW contributed to conceptualization, literature review, draft the article, critically review the article, and approve the final manuscript; SK, MH, YN, and AS contributed to conceptualization, critically review the article, and approve the final manuscript.

Corresponding author

Correspondence to Sirote Wongwaisayawan.

Ethics declarations

Conflict of interest

The authors declare that they have no conflict of interests.

Additional information

Publisher's Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Wongwaisayawan, S., Krishna, S., Haroon, M. et al. Fournier gangrene: pictorial review. Abdom Radiol 45, 3838–3848 (2020). https://doi.org/10.1007/s00261-020-02549-9

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00261-020-02549-9

Keywords

Navigation