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Shear wave liver elastography

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Abstract

Chronic liver disease is a substantial world-wide problem. Its major consequence is increasing deposition of fibrous tissue within the liver leading to the development of cirrhosis with its consequences of portal hypertension, hepatic insufficiency, and hepatocellular carcinoma. The stage of liver fibrosis is important to determine prognosis, surveillance, prioritize for treatment, and potential for reversibility. The process of fibrosis is dynamic and regression of fibrosis is possible with treatment of the underlying conditions. Previously, the only method of staging the degree of fibrosis was liver biopsy. The recent development of ultrasound elastography techniques allows a non-invasive method of estimating the degree of liver fibrosis. Transient elastography (TE) is a non-imaging elastographic technique, while point shear wave (p-SWE) and 2D-SWE combine imaging with elastography. The evidence at this time suggests that p-SWE is as accurate as but more reliable than TE, while 2D-SWE is more accurate than TE. This review discusses the background of chronic liver disease, the types of ultrasound elastography, how to perform an examination, and how to interpret the results.

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References

  1. Scaglione S, et al. (2015) The epidemiology of cirrhosis in the United States: a population-based study. J Clin Gastroenterol 49(8):690–696

    Article  PubMed  Google Scholar 

  2. Chapman T, Dubinsky T, Barr RG, (2017) Ultrasound elastography of the liver: what the clinician needs to know. J Ultrasound Med

  3. Myers RP, Fong A, Shaheen AA (2008) Utilization rates, complications and costs of percutaneous liver biopsy: a population-based study including 4275 biopsies. Liver Int 28(5):705–712

    Article  PubMed  Google Scholar 

  4. Seeff LB, et al. (2010) Complication rate of percutaneous liver biopsies among persons with advanced chronic liver disease in the HALT-C trial. Clin Gastroenterol Hepatol 8(10):877–883

    Article  PubMed  PubMed Central  Google Scholar 

  5. Colloredo G, et al. (2003) Impact of liver biopsy size on histological evaluation of chronic viral hepatitis: the smaller the sample, the milder the disease. J Hepatol 39(2):239–244

    Article  PubMed  Google Scholar 

  6. Goodman ZD (2007) Grading and staging systems for inflammation and fibrosis in chronic liver diseases. J Hepatol 47(4):598–607

    Article  PubMed  Google Scholar 

  7. Anthony PP, et al. (1977) The morphology of cirrhosis: definition, nomenclature, and classification. Bull World Health Organ 55(4):521–540

    CAS  PubMed  PubMed Central  Google Scholar 

  8. Barr RG, et al. (2016) Elastography assessment of liver fibrosis: society of radiologists in ultrasound consensus conference statement. Ultrasound Q 32(2):94–107

    Article  PubMed  Google Scholar 

  9. Younossi ZM, et al. (2011) Pathologic criteria for nonalcoholic steatohepatitis: interprotocol agreement and ability to predict liver-related mortality. Hepatology 53(6):1874–1882

    Article  PubMed  Google Scholar 

  10. Gines P, et al. (1987) Compensated cirrhosis: natural history and prognostic factors. Hepatology 7(1):122–128

    Article  CAS  PubMed  Google Scholar 

  11. Bruno S, et al. (2009) Predicting mortality risk in patients with compensated HCV-induced cirrhosis: a long-term prospective study. Am J Gastroenterol 104(5):1147–1158

    Article  PubMed  Google Scholar 

  12. D’Amico G, Garcia-Tsao G, Pagliaro L (2006) Natural history and prognostic indicators of survival in cirrhosis: a systematic review of 118 studies. J Hepatol 44(1):217–231

    Article  PubMed  Google Scholar 

  13. Ripoll C, et al. (2007) Hepatic venous pressure gradient predicts clinical decompensation in patients with compensated cirrhosis. Gastroenterology 133(2):481–488

    Article  CAS  PubMed  Google Scholar 

  14. Blasco A, et al. (2006) Hepatic venous pressure gradient identifies patients at risk of severe hepatitis C recurrence after liver transplantation. Hepatology 43(3):492–499

    Article  PubMed  Google Scholar 

  15. Nagula S, et al. (2006) Histological-hemodynamic correlation in cirrhosis-a histological classification of the severity of cirrhosis. J Hepatol 44(1):111–117

    Article  PubMed  Google Scholar 

  16. Barr RG (2012) Sonographic breast elastography: a primer. J Ultrasound Med 31(5):773–783

    Article  PubMed  Google Scholar 

  17. Shiina T, et al. (2015) WFUMB guidelines and recommendations for clinical use of ultrasound elastography: part 1: basic principles and terminology. Ultrasound Med Biol 41(5):1126–1147

    Article  PubMed  Google Scholar 

  18. Venkatesh SK, Ehman RL (2014) Magnetic resonance elastography of liver. Magn Reson Imaging Clin N Am 22(3):433–446

    Article  PubMed  Google Scholar 

  19. Venkatesh SK, Yin M, Ehman RL (2013) Magnetic resonance elastography of liver: technique, analysis, and clinical applications. J Magn Reson Imaging 37(3):544–555

    Article  PubMed  PubMed Central  Google Scholar 

  20. Arena U, et al. (2008) Reliability of transient elastography for the diagnosis of advanced fibrosis in chronic hepatitis C. Gut 57(9):1288–1293

    Article  CAS  PubMed  Google Scholar 

  21. Castera L, Pawlotsky JM (2005) Noninvasive diagnosis of liver fibrosis in patients with chronic hepatitis C. MedGenMed 7(4):39

    PubMed  PubMed Central  Google Scholar 

  22. Fraquelli M, et al. (2007) Reproducibility of transient elastography in the evaluation of liver fibrosis in patients with chronic liver disease. Gut 56(7):968–973

    Article  PubMed  PubMed Central  Google Scholar 

  23. Kirk GD, et al. (2009) Assessment of liver fibrosis by transient elastography in persons with hepatitis C virus infection or HIV-hepatitis C virus coinfection. Clin Infect Dis 48(7):963–972

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  24. Lupsor M, et al. (2008) Analysis of histopathological changes that influence liver stiffness in chronic hepatitis C. Results from a cohort of 324 patients. J Gastrointest Liver Dis 17(2):155–163

    Google Scholar 

  25. Shaheen AA, Wan AF, Myers RP (2007) FibroTest and FibroScan for the prediction of hepatitis C-related fibrosis: a systematic review of diagnostic test accuracy. Am J Gastroenterol 102(11):2589–2600

    Article  PubMed  Google Scholar 

  26. Castera L, et al. (2005) Prospective comparison of transient elastography, Fibrotest, APRI, and liver biopsy for the assessment of fibrosis in chronic hepatitis C. Gastroenterology 128(2):343–350

    Article  PubMed  Google Scholar 

  27. Friedrich-Rust M, et al. (2008) Performance of transient elastography for the staging of liver fibrosis: a meta-analysis. Gastroenterology 134(4):960–974

    Article  PubMed  Google Scholar 

  28. Chan HL, et al. (2009) Hepatitis B virus genotype C is associated with more severe liver fibrosis than genotype B. Clin Gastroenterol Hepatol 7(12):1361–1366

    Article  PubMed  Google Scholar 

  29. Coco B, et al. (2007) Transient elastography: a new surrogate marker of liver fibrosis influenced by major changes of transaminases. J Viral Hepat 14(5):360–369

    Article  CAS  PubMed  Google Scholar 

  30. Degos F, et al. (2010) Diagnostic accuracy of FibroScan and comparison to liver fibrosis biomarkers in chronic viral hepatitis: a multicenter prospective study (the FIBROSTIC study). J Hepatol 53(6):1013–1021

    Article  PubMed  Google Scholar 

  31. Marcellin P, et al. (2009) Non-invasive assessment of liver fibrosis by stiffness measurement in patients with chronic hepatitis B. Liver Int 29(2):242–247

    Article  PubMed  Google Scholar 

  32. Oliveri F, et al. (2008) Liver stiffness in the hepatitis B virus carrier: a non-invasive marker of liver disease influenced by the pattern of transaminases. World J Gastroenterol 14(40):6154–6162

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  33. Pineda JA, et al. (2009) Liver stiffness as a predictor of esophageal varices requiring therapy in HIV/hepatitis C virus-coinfected patients with cirrhosis. J Acquir Immune Defic Syndr 51(4):445–449

    Article  PubMed  Google Scholar 

  34. Vergara S, et al. (2007) The use of transient elastometry for assessing liver fibrosis in patients with HIV and hepatitis C virus coinfection. Clin Infect Dis 45(8):969–974

    Article  PubMed  Google Scholar 

  35. Petta S, et al. (2011) Hepatic steatosis and insulin resistance are associated with severe fibrosis in patients with chronic hepatitis caused by HBV or HCV infection. Liver Int 31(4):507–515

    Article  CAS  PubMed  Google Scholar 

  36. Wong VW, et al. (2010) Diagnosis of fibrosis and cirrhosis using liver stiffness measurement in nonalcoholic fatty liver disease. Hepatology 51(2):454–462

    Article  CAS  PubMed  Google Scholar 

  37. Yoneda M, et al. (2008) Noninvasive assessment of liver fibrosis by measurement of stiffness in patients with nonalcoholic fatty liver disease (NAFLD). Dig Liver Dis 40(5):371–378

    Article  CAS  PubMed  Google Scholar 

  38. Fahey BJ, et al. (2005) Acoustic radiation force impulse imaging of the abdomen: demonstration of feasibility and utility. Ultrasound Med Biol 31(9):1185–1198

    Article  PubMed  Google Scholar 

  39. Ferraioli G, et al. (2015) WFUMB guidelines and recommendations for clinical use of ultrasound elastography: part 3: liver. Ultrasound Med Biol 41(5):1161–1179

    Article  PubMed  Google Scholar 

  40. Friedrich-Rust M, et al. (2012) Performance of Acoustic Radiation Force Impulse imaging for the staging of liver fibrosis: a pooled meta-analysis. J Viral Hepat 19(2):e212–e219

    Article  CAS  PubMed  Google Scholar 

  41. Bota S, et al. (2013) Meta-analysis: ARFI elastography versus transient elastography for the evaluation of liver fibrosis. Liver Int 33(8):1138–1147

    Article  PubMed  Google Scholar 

  42. Ferraioli G, et al. (2014) Ultrasound point shear wave elastography assessment of liver and spleen stiffness: effect of training on repeatability of measurements. Eur Radiol 24(6):1283–1289

    Article  PubMed  Google Scholar 

  43. Bota S, et al. (2012) Intra- and interoperator reproducibility of acoustic radiation force impulse (ARFI) elastography–preliminary results. Ultrasound Med Biol 38(7):1103–1108

    Article  PubMed  Google Scholar 

  44. D’Onofrio M, Gallotti A, Mucelli RP (2010) Tissue quantification with acoustic radiation force impulse imaging: measurement repeatability and normal values in the healthy liver. AJR Am J Roentgenol 195(1):132–136

    Article  PubMed  Google Scholar 

  45. Ferraioli G, et al. (2014) Shear wave elastography for evaluation of liver fibrosis. J Ultrasound Med 33(2):197–203

    Article  PubMed  Google Scholar 

  46. Ferraioli G, et al. (2012) Performance of real-time strain elastography, transient elastography, and aspartate-to-platelet ratio index in the assessment of fibrosis in chronic hepatitis C. AJR Am J Roentgenol 199(1):19–25

    Article  PubMed  Google Scholar 

  47. Bavu E, et al. (2011) Noninvasive in vivo liver fibrosis evaluation using supersonic shear imaging: a clinical study on 113 hepatitis C virus patients. Ultrasound Med Biol 37(9):1361–1373

    Article  PubMed  Google Scholar 

  48. Cassinotto C, et al. (2013) Liver fibrosis: noninvasive assessment with acoustic radiation force impulse elastography—comparison with FibroScan M and XL probes and FibroTest in patients with chronic liver disease. Radiology 269(1):283–292

    Article  PubMed  Google Scholar 

  49. Jeong JY, et al. (2014) Real time shear wave elastography in chronic liver diseases: accuracy for predicting liver fibrosis, in comparison with serum markers. World J Gastroenterol 20(38):13920–13929

    Article  PubMed  PubMed Central  Google Scholar 

  50. Li C, et al. (2016) Diagnostic accuracy of real-time shear wave elastography for staging of liver fibrosis: a meta-analysis. Med Sci Monit 22:1349–1359

    Article  PubMed  PubMed Central  Google Scholar 

  51. Ferraioli G, et al. (2012) Accuracy of real-time shear wave elastography for assessing liver fibrosis in chronic hepatitis C: a pilot study. Hepatology 56(6):2125–2133

    Article  PubMed  Google Scholar 

  52. Cassinotto C, et al. (2014) Non-invasive assessment of liver fibrosis with impulse elastography: comparison of Supersonic Shear Imaging with ARFI and FibroScan(R). J Hepatol 61(3):550–557

    Article  PubMed  Google Scholar 

  53. Hall TJ, Milkowski A, Garra B, et. al. (2013) RSNA/QIBA: Shear wave speed as a biomarker for liver fibrosis staging. In: Ultrasonics Symposium (IUS), pp. 397–400.

  54. Dietrich CF, et al. (2017) EFSUMB guidelines and recommendations on the clinical use of liver ultrasound elastography, update 2017 (long version). Ultraschall Med 38(4):e16–e47

    Article  PubMed  Google Scholar 

  55. Barr RG, Ferraioli G, Levine D (2016) Response. Radiology 278(1):303–304

    Article  PubMed  Google Scholar 

  56. Barr RG, Zhang Z (2012) Effects of precompression on elasticity imaging of the breast: development of a clinically useful semiquantitative method of precompression assessment. J Ultrasound Med 31(6):895–902

    Article  PubMed  Google Scholar 

  57. Dong Y, et al. (2017) Shear wave elastography of the liver—review on normal values. Z Gastroenterol 55(2):153–166

    Article  PubMed  Google Scholar 

  58. Colecchia A, et al. (2012) Measurement of spleen stiffness to evaluate portal hypertension and the presence of esophageal varices in patients with HCV-related cirrhosis. Gastroenterology 143(3):646–654

    Article  PubMed  Google Scholar 

  59. Takuma Y, et al. (2013) Measurement of spleen stiffness by acoustic radiation force impulse imaging identifies cirrhotic patients with esophageal varices. Gastroenterology 144(1):92–101

    Article  PubMed  Google Scholar 

  60. Fraquelli M, et al. (2014) Feasibility and reproducibility of spleen transient elastography and its role in combination with liver transient elastography for predicting the severity of chronic viral hepatitis. J Viral Hepat 21(2):90–98

    Article  CAS  PubMed  Google Scholar 

  61. Kim HY, et al. (2015) The role of spleen stiffness in determining the severity and bleeding risk of esophageal varices in cirrhotic patients. Medicine (Baltimore) 94(24):e1031

    Article  Google Scholar 

  62. Yu H, Wilson SR (2011) Differentiation of benign from malignant liver masses with acoustic radiation force impulse technique. Ultrasound Q 27(4):217–223

    Article  PubMed  Google Scholar 

  63. Ferraioli G, et al. (2014) Point shear wave elastography method for assessing liver stiffness. World J Gastroenterol 20(16):4787–4796

    Article  PubMed  PubMed Central  Google Scholar 

  64. Bende F, et al. (2017) Performance of 2D-SWE GE for predicting different stages of liver fibrosis, using transient elastography as the reference method. Med Ultrason 19(2):143–149

    Article  PubMed  Google Scholar 

  65. Lijima H (2014) Approaches to the Diagnosis of Liver Fibrosis, in Toshiba Medical Systems Corporation, H.C.o. Medicine, Editor. Toshiba Medical: http://www.toshibamedicalsystems.com/.

  66. Ferraioli G, et al. (2017) Ruling-in and ruling-out significant fibrosis and cirrhosis in patients with chronic hepatitis C using a shear wave measurement method. J Gastrointest Liver Dis 26(2):139–143

    Google Scholar 

  67. Tsochatzis EA, et al. (2011) Elastography for the diagnosis of severity of fibrosis in chronic liver disease: a meta-analysis of diagnostic accuracy. J Hepatol 54(4):650–659

    Article  CAS  PubMed  Google Scholar 

  68. Iain D (2017) Shear wave elastography in the evaluation of the liver from a 300-patient study

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Correspondence to Richard G. Barr.

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Conflict of interest

Dr. Barr has research grants from Philips Ultrasound, Siemens Ultrasound, SuperSonic Imagine, B and K Ultrasound. He is on the speaker’s bureau of Philips Ultrasound and Bracco Diagnostics. He is on the advisory board of Bracco Diagnostics and Lantheus Medical. He receives royalties from Thieme Publishers.

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This article does not contain any studies with human participants or animals performed by any of the authors.

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Barr, R.G. Shear wave liver elastography. Abdom Radiol 43, 800–807 (2018). https://doi.org/10.1007/s00261-017-1375-1

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