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Scurvy: an unusual complication of paediatric cancer treatment

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Abstract

Scurvy is a disease that is rarely encountered in modern medicine. A condition that was classically associated with sailors, its incidence has decreased dramatically since the discovery of its association with vitamin C deficiency. We present the case of a 2-year-old boy, whose treatment for neuroblastoma was complicated by gastrointestinal disease, which necessitated enteral feeding. While still undergoing treatment, he started to complain about increasing pain in his lower limbs, which appeared to be markedly tender on palpation. Radiographic findings suggested a diagnosis of scurvy, which was subsequently confirmed on serum biochemistry. This was an unexpected finding, as the child had been receiving adequate vitamin C in his enteral feeds. However, his absorption had become severely impaired due to pseudomembranous gastritis and enteritis, leading to his deficient state. He significantly improved after intravenous ascorbic acid replacement and demonstrated a full recovery, both clinically and radiologically. This case highlights the importance of considering scurvy in the differential diagnosis for at-risk patients. Early recognition can facilitate the simple treatment of this potentially serious condition.

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Correspondence to Iain Irvine.

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The authors declare that they have no conflicts of interest. No funding was received for this article.

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This article does not contain any studies with human participants or animals performed by any of the authors.

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Informed consent to publish this article was obtained from the patient’s mother.

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Irvine, I., Walshe, T., Capra, M. et al. Scurvy: an unusual complication of paediatric cancer treatment. Skeletal Radiol 48, 995–998 (2019). https://doi.org/10.1007/s00256-018-3103-5

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  • DOI: https://doi.org/10.1007/s00256-018-3103-5

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