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Review of research on Dendrobium, a prized folk medicine

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Abstract

Medicinal plants of the Dendrobium genus are highly prized, and hence, methodologies have been developed to authenticate Dendrobium drugs from its adulterants. Many bioactive constituents of Dendrobium species have been identified. The macromolecules included lectins; the enzymes chalcone synthase, sucrose synthase, and cytokinin oxidase; and polysaccharides. The polysaccharides display immunomodulatory and hepatoprotective activities. Alkaloids exhibit antioxidant, anticancer, and neuroprotective activities. Other compounds manifest antioxidant, anticancer, and immunomodulatory.

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References

  • Bi ZM, Wang ZT, Xu LS, Xu GJ (2003) Studies on the chemical constituents of Dendrobium fimbriatum. Yao Xue Xue Bao 38:526–529

    CAS  Google Scholar 

  • Chang CC, Ku AF, Tseng YY, Yang WB, Fang JM, Wong CH (2010) 6,8-Di-C-glycosyl flavonoids from Dendrobium huoshanense. J Nat Prod 73:229–232

    Article  CAS  Google Scholar 

  • Chen CC, Wu LG, Ko FN, Teng CM (1994) Antiplatelet aggregation principles of Dendrobium loddigesii. J Nat Prod 57:1271–1274

    Article  CAS  Google Scholar 

  • Ding YP, Wu LS, Yu LW (1998) Optimized harvesting period for Dendrobium candidum. Chi J Chin Mater Med 23:458–460

    CAS  Google Scholar 

  • Ding G, Ding XY, Shen J, Tang F, Liu DY, He J, Li XX, Chu BH (2005) Genetic diversity and molecular authentication of wild populations of Dendrobium officinale by RAPD. Yao Xue Xue Bao 40:1028–1032

    Google Scholar 

  • Fan Y, He X, Zhou S, Luo A, He T, Chun Z (2009) Composition analysis and antioxidant activity of polysaccharide from Dendrobium denneanum. Int J Biol Macromol 45:169–173

    Article  CAS  Google Scholar 

  • Gong YQ, Yang H, Liu Y, Liang AQ, Wang ZT, Xu LS, Hu ZB (2006) Studies on chemical constituents in stem of Dendrobium chrysotoxum. Zhongguo Zhong Yao Za Zhi 31:304–306

    CAS  Google Scholar 

  • Hu JM, Chen JJ, Yu H, Zhao YX, Zhou J (2008a) Five new compounds from Dendrobium longicornu. Planta Med 74:535–539

    Article  CAS  Google Scholar 

  • Hu JM, Chen JJ, Yu H, Zhao YX, Zhou J (2008b) Two novel bibenzyls from Dendrobium trigonopus. J Asian Nat Prod Res 10:653–657

    Google Scholar 

  • Hua YF, Zhang M, Fu CX, Chen ZH, Chan GY (2004) Structural characterization of a 2–O–acetylglucomannan from Dendrobium officinale stem. Carbohydr Res 339:2219–2224

    Article  CAS  Google Scholar 

  • Hwang JS, Lee SA, Hong SS, Han XH, Lee C, Kang SJ, Lee D, Kim Y, Hong JT, Lee MK, Hwang BY (2010) Phenanthrenes from Dendrobium nobile and their inhibition of the LPS-induced production of nitric oxide in macrophage RAW 264.7 cells. Bioorg Med Chem Lett 20:3785–3787

    Article  CAS  Google Scholar 

  • Ito M, Matsuzaki K, Wang J, Daikonya A, Wang NL, Yao XS, Kitanaka S (2010) New phenanthrenes and stilbenes from Dendrobium loddigesii. Chem Pharm Bull (Tokyo) 58:628–633

    Article  CAS  Google Scholar 

  • Jin J, Liang Y, Xie H, Zhang X, Yao X, Wang Z (2008) Dendroflorin retards the senescence of MRC-5 cells. Pharmazie 63:321–323

    CAS  Google Scholar 

  • Lau DT, Shaw PC, Wang J, But PP (2001) Authentication of medicinal Dendrobium species by the internal transcribed spacer of ribosomal DNA. Planta Med 67:456–460

    Article  CAS  Google Scholar 

  • Li Y, Wang CL, Wang YJ, Wang FF, Guo SX, Yang JS, Xiao PG (2009a) Four new bibenzyl derivatives from Dendrobium candidum. Chem Pharm Bull (Tokyo) 57:997–999

    Article  CAS  Google Scholar 

  • Li Y, Wang CL, Wang YJ, Guo SX, Yang JS, Chen XM, Xiao PG (2009b) Three new bibenzyl derivatives from Dendrobium candidum. Chem Pharm Bull (Tokyo) 57:218–219

    Article  CAS  Google Scholar 

  • Li Y, Wang C, Wang F, Dong H, Guo S, Yang J, Xiao P (2010) Chemical constituents of Dendrobium candidum. Zhongguo Zhong Yao Za Zhi 35:1715–1719

    CAS  Google Scholar 

  • Li Y, Li F, Gong Q, Wu Q, Shi J (2011) Inhibitory effects of Dendrobium alkaloids on memory impairment induced by lipopolysaccharide in rats. Planta Med 77:117–121

    Article  CAS  Google Scholar 

  • Liu CR, Pan XR (2002) The study of clinic and pharmacology in Dendrobium species. TCM Guangxi 25:6–8

    Google Scholar 

  • Liu Q, Zhou W, Zhao RF (2005) 36 cases analysis for Sjögren’s symptom by Chinese medicine. Chi Clin Rehabilitat 9:234–235

    CAS  Google Scholar 

  • Liu J, He T, Chun Z (2009) DNA molecular identification of Herba Dendrobii and its adulterant species based on ITS sequence analysis. Zhongguo Zhong Yao Za Zhi 34:2853–2856

    CAS  Google Scholar 

  • Liu XF, Zhu J, Ge SY, Xia LJ, Yang HY, Qian YT, Ren FZ (2011) Orally administered Dendrobium officinale and its polysaccharides enhance immune functions in BALB/c mice. Nat Prod Commun 6:867–870

    CAS  Google Scholar 

  • Luo A, Ge Z, Fan Y, Luo A, Chun Z, He X (2011) In vitro and in vivo antioxidant activity of a water-soluble polysaccharide from Dendrobium denneanum. Molecules 16:1579–1592

    Article  CAS  Google Scholar 

  • Magwere T (2009) Escaping immune surveillance in cancer: is denbinobin the panacea? Br J Pharmacol 157:1172–1174

    Article  CAS  Google Scholar 

  • Meng H, Duan C, Xiao F, Yang S, Zha Y, Wen G (2011) Molecular cloning and expression analysis of sucrose synthase gene from Dendrobium officinale. Zhongguo Zhong Yao Za Zhi 36:833–837

    CAS  Google Scholar 

  • Pan LH, Lu J, Luo JP, Zha XQ, Wang JH (2012) Preventive effect of a galactoglucomannan (GGM) from Dendrobium huoshanense on selenium-induced liver injury and fibrosis in rats. Exp Toxicol Pathol (in press)

  • Pitakdantham W, Sutabutra T, Chiemsombat P, Pitaksutheepong C (2010) Isolation and characterization of chalcone synthase gene isolated from Dendrobium sonia Earsakul. Pak J Biol Sci 13:1000–1005

    Article  CAS  Google Scholar 

  • Qian L, Ding G, Zhou Q, Feng Z, Ding X, Gu S, Wang Y, Li X, Chu B (2008) Molecular authentication of Dendrobium loddigesii Rolfe by amplification refractory mutation system (ARMS). Planta Med 74:470–473

    Article  CAS  Google Scholar 

  • Sánchez-Duffhues G, Calzado MA, de Vinuesa AG, Appendino G, Fiebich BL, Loock U, Lefarth-Risse A, Krohn K, Muñoz E (2009) Denbinobin inhibits nuclear factor-kappaB and induces apoptosis via reactive oxygen species generation in human leukemic cells. Biochem Pharmacol 77:1401–1409

    Article  Google Scholar 

  • Sattayasai N, Sudmoon R, Nuchadomrong S, Chaveerach A, Kuehnle AR, Mudalige-Jayawickrama RG, Bunyatratchata W (2009) Dendrobium findleyanum agglutinin: production, localization, anti-fungal activity and gene characterization. Plant Cell Rep 28:1243–1252

    Article  CAS  Google Scholar 

  • Shu Y, Zhang DM, Guo SX (2004) A new sesquiterpene glycoside from Dendrobium nobile Lindl. J Asian Nat Prod Res 6:311–314

    Article  CAS  Google Scholar 

  • Sritularak B, Anuwat M, Likhitwitayawuid K (2011a) A new phenanthrenequinone from Dendrobium draconis. J Asian Nat Prod Res 13:251–255

    Article  CAS  Google Scholar 

  • Sritularak B, Duangrak N, Likhitwitayawuid K (2011b) A new bibenzyl from Dendrobium secundum. Z Naturforsch C 66:205–208

    CAS  Google Scholar 

  • Sudmoon R, Sattayasai N, Bunyatratchata W, Chaveerach A, Nuchadomrong S (2008) Thermostable mannose-binding lectin from Dendrobium findleyanum with activities dependent on sulfhydryl content. Acta Biochim Biophys Sin (Shanghai) 40:811–818

    CAS  Google Scholar 

  • Sze SC, Zhang KY, Shaw PC, But PP, Ng TB, Tong Y (2008) A DNA microarray for differentiation of (Fengdou Shihu) by its 5 S ribosomal DNA intergenic spacer region. Biotechnol Appl Biochem 49:149–154

    Article  CAS  Google Scholar 

  • Takamiya T, Wongsawad P, Tajima N, Shioda N, Lu JF, Wen CL, Wu JB, Handa T, Iijima H, Kitanaka S, Yukawa T (2011) Identification of Dendrobium species used for herbal medicines based on ribosomal DNA internal transcribed spacer sequence. Biol Pharm Bull 34:7797–82

    Article  Google Scholar 

  • Tsai AC, Pan SL, Liao CH, Guh JH, Wang SW, Sun HL, Liu YN, Chen CC, Shen CC, Chang YL, Teng CM (2010) Moscatilin, a bibenzyl derivative from the India orchid Dendrobium loddigesii, suppresses tumor angiogenesis and growth in vitro and in vivo. Cancer Lett 292:163–170

    Article  CAS  Google Scholar 

  • Wang M, Zhang CF, Wang ZT, Zhang M (2007) Studies on constituents of Dendrobium gratiosissimum. Zhongguo Zhong Yao Za Zhi 32:701–703

    CAS  Google Scholar 

  • Wang L, Zhang CF, Wang ZT, Zhang M, Shao L, Xu LS (2008) Studies on chemical constituents of Dendrobium crystallinum. Zhongguo Zhong Yao Za Zhi 33:1847–1848

    CAS  Google Scholar 

  • Wang L, Zhang CF, Wang ZT, Zhang M, Xu LS (2009a) Five new compounds from Dendrobium crystallinum. J Asian Nat Prod Res 11:903–911

    Article  CAS  Google Scholar 

  • Wang Y, Luo JP, Wei ZJ, Zhang JC (2009b) Molecular cloning and expression analysis of a cytokinin oxidase (DhCKX) gene in Dendrobium huoshanense. Mol Biol Rep 36:1331–1338

    Article  CAS  Google Scholar 

  • Wang JH, Zha XQ, Luo JP, Yang XF (2010a) An acetylated galactomannoglucan from the stems of Dendrobium nobile Lindl. Carbohydr Res 345:1023–1027

    Article  CAS  Google Scholar 

  • Wang Q, Gong Q, Wu Q, Shi J (2010b) Neuroprotective effects of Dendrobium on rat cortical neurons injured by oxygen-glucose deprivation and reperfusion. Phytomed 17:108–115

    Article  Google Scholar 

  • Wei X (2005) Alkaloid study on Dendrobium species. China Pharmaceut 19:445–447

    CAS  Google Scholar 

  • Wu KG, Li TH, Chen CJ, Cheng HI, Wang TY (2011) A pilot study evaluating the clinical and immunomodulatory effects of an orally administered extract of Dendrobium huoshanense in children with moderate to severe recalcitrant atopic dermatitis. Int J Immunopathol Pharmacol 24:367–375

    CAS  Google Scholar 

  • Xiao L, Ng TB, Feng YB, Yao T, Wong JH, Yao RM, Li L, Mo FZ, Xiao Y, Shaw PC, Li ZM, Sze SC, Zhang KY (2011) Dendrobium candidum extract increases the expression of aquaporin-5 in labial glands from patients with Sjögren’s syndrome. Phytomed 18:194–198

    Article  CAS  Google Scholar 

  • Xu JH, Li L, Chen LZ (1995) Studies on the effects of white Dendrobium (Dendrobium candicum) and American ginseng (Panax quinquefolius) on nourishing the Yin and promoting glandular secretion in mice and rabbits. Chin Trad Herb Drug 6:79–80

    Google Scholar 

  • Yang H, Chou GX, Wang ZT, Hu ZB, Xu LS (2004) Two new fluorenones from Dendrobium chrysotoxum. J Asian Nat Prod Res 6:35–38

    Article  Google Scholar 

  • Yang L, Qin LH, Bligh SW, Bashall A, Zhang CF, Zhang M, Wang ZT, Xu LS (2006) A new phenanthrene with a spirolactone from Dendrobium chrysanthum and its anti-inflammatory activities. Bioorg Med Chem 14:3496–3501

    Article  CAS  Google Scholar 

  • Yang L, Han H, Nakamura N, Hattori M, Wang Z, Xu L (2007) Bio-guided isolation of antioxidants from the stems of Dendrobium aurantiacum var. denneanum. Phytother Res 21:696–698

    Article  CAS  Google Scholar 

  • Yang LC, Deng H, Yi Y, Zhang XM, Wang YZ, Lin JQ (2010) Identification of medical Dendrobium herbs by ISSR marker. Zhong Yao Cai 33:1841–1844

    CAS  Google Scholar 

  • Ye QH, Zhao WM, Qin GW (2003) New fluorenone and phenanthrene derivatives from Dendrobium chrysanthum. Nat Prod Res 17:201–205

    Article  CAS  Google Scholar 

  • Ye QH, Zhao WM, Qin GW (2004) Lignans from Dendrobium chrysanthum. J Asian Nat Prod Res 6:39–43

    Article  CAS  Google Scholar 

  • Yoon MY, Hwang JH, Park JH, Lee MR, Kim HJ, Park E, Park HR (2011) Neuroprotective effects of SG-168 against oxidative stress-induced apoptosis in PC12 cells. J Med Food 14:120–127

    Article  Google Scholar 

  • Zhang YB, Wang J, Wang ZT, But PP, Shaw PC (2003) DNA microarray for identification of the herb of Dendrobium species from Chinese medicinal formulations. Planta Med 69:1172–1174

    Article  CAS  Google Scholar 

  • Zhang X, Gao H, Wang NL, Yao XS (2006) Three new bibenzyl derivatives from Dendrobium nobile. J Asian Nat Prod Res 8:113–118

    Article  CAS  Google Scholar 

  • Zhang X, Xu JK, Wang J, Wang NL, Kurihara H, Kitanaka S, Yao XS (2007) Bioactive bibenzyl derivatives and fluorenones from Dendrobium nobile. J Nat Prod 70:24–28

    Article  CAS  Google Scholar 

  • Zhang CF, Shao L, Huang WH, Wang L, Wang ZT, Xu LS (2008a) Phenolic components from herbs of Dendrobium aphyllum. Zhongguo Zhong Yao Za Zhi 33:2922–2925

    CAS  Google Scholar 

  • Zhang X, Tu FJ, Yu HY, Wang NL, Wang Z, Yao XS (2008b) Copacamphane, picrotoxane and cyclocopacamphane sesquiterpenes from Dendrobium nobile. Chem Pharm Bull (Tokyo) 56:854–857

    Article  CAS  Google Scholar 

  • Zhao C, Liu Q, Halaweish F, Shao B, Ye Y, Zhao W (2003) Copacamphane, picrotoxane, and alloaromadendrane sesquiterpene glycosides and phenolic glycosides from Dendrobium moniliforme. J Nat Prod 66:1140–1143

    Article  CAS  Google Scholar 

  • Zheng Y (2005) Shihu in China Pharmacopoeia. Chemical Technology, Beijing, pp 61–63

    Google Scholar 

  • Zheng WP, Tang YP, Zhi F, Lou FC (2000) Dihydroayapin, a new coumarin compound from Dendrobium densiflorum. J Asian Nat Prod Res 2:301–304

    Article  CAS  Google Scholar 

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Acknowledgments

This work was supported by grants (funding from Stanley Ho Alumni Challenge of the University of Hong Kong (no. 20830019) and funds from Oriental Int Health Products Co., Ltd. (no 20006390)). We thank Mr. Randy Cheung for secretarial assistance.

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Authors and Affiliations

  1. School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong, China

    Tzi Bun Ng & Jack Ho Wong

  2. School of Chinese Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Sassoon Road, Hong Kong, China

    Jingyi Liu, Stephen Cho Wing Sze, Yao Tong & Kalin Yanbo Zhang

  3. Institute of Plant Virology, Fujian Province Key Laboratory of Plant Virology, Fujian Agriculture and Forestry University, Fuzhou, Fujian, 350002, China

    Xiujuan Ye

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  1. Tzi Bun Ng
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  2. Jingyi Liu
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  3. Jack Ho Wong
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  4. Xiujuan Ye
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  5. Stephen Cho Wing Sze
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  6. Yao Tong
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  7. Kalin Yanbo Zhang
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Correspondence to Kalin Yanbo Zhang.

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Tzi Bun Ng and Jingyi Liu contributed equally to this article.

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Ng, T.B., Liu, J., Wong, J.H. et al. Review of research on Dendrobium, a prized folk medicine. Appl Microbiol Biotechnol 93, 1795–1803 (2012). https://doi.org/10.1007/s00253-011-3829-7

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  • DOI: https://doi.org/10.1007/s00253-011-3829-7

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