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Class II MHC antigen processing in immune tolerance and inflammation

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Abstract

Presentation of peptide antigens by MHC-II proteins is prerequisite to effective CD4 T cell tolerance to self and to recognition of foreign antigens. Antigen uptake and processing pathways as well as expression of the peptide exchange factors HLA-DM and HLA-DO differ among the various professional and non-professional antigen-presenting cells and are modulated by cell developmental state and activation. Recent studies have highlighted the importance of these cell-specific factors in controlling the source and breadth of peptides presented by MHC-II under different conditions. During inflammation, increased presentation of selected self-peptides has implications for maintenance of peripheral tolerance and autoimmunity.

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Funding

This study was funded by grant AI-127869 from the US National Institutes of Health.

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  1. Immunology and Microbiology Graduate Program and Department of Pathology, University of Massachusetts Medical School, Worcester, MA, 01655, USA

    Mollie M. Jurewicz & Lawrence J. Stern

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  1. Mollie M. Jurewicz
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Correspondence to Lawrence J. Stern.

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This article is part of the Topical Collection on Biology and Evolution of Antigen Presentation

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Jurewicz, M.M., Stern, L.J. Class II MHC antigen processing in immune tolerance and inflammation. Immunogenetics 71, 171–187 (2019). https://doi.org/10.1007/s00251-018-1095-x

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