Abstract
The success of surgical management of lower pole stones is principally dependent on stone fragmentation and residual stone clearance. Choice of surgical method depends on stone size, yet all methods are subjected to post-surgical complications resulting from residual stone fragments. Here we present a novel method and device to reposition kidney stones using ultrasound radiation force delivered by focused ultrasound and guided by ultrasound imaging. The device couples a commercial imaging array with a focused annular array transducer. Feasibility of repositioning stones was investigated by implanting artificial and human stones into a kidney-mimicking phantom that simulated a lower pole and collecting system. During experiment, stones were located by ultrasound imaging and repositioned by delivering short bursts of focused ultrasound. Stone motion was concurrently monitored by fluoroscopy, ultrasound imaging, and video photography, from which displacement and velocity were estimated. Stones were seen to move immediately after delivering focused ultrasound and successfully repositioned from the lower pole to the collecting system. Estimated velocities were on the order of 1 cm/s. This in vitro study demonstrates a promising modality to facilitate spontaneous clearance of kidney stones and increased clearance of residual stone fragments after surgical management.
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Acknowledgments
We thank our colleagues at the Center for Industrial and Medical Ultrasound and the Consortium for Shock Waves in Medicine for advice, shared resources, and review. This work was supported by a grant from the National Space Biomedical Research Institute NCC9-58, NIH DK43881, and NIH DK086371.
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Proceedings paper from the 3rd International Urolithiasis Research Symposium, Indianapolis, Indiana, USA, December 3–4, 2009.
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Shah, A., Owen, N.R., Lu, W. et al. Novel ultrasound method to reposition kidney stones. Urol Res 38, 491–495 (2010). https://doi.org/10.1007/s00240-010-0319-9
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DOI: https://doi.org/10.1007/s00240-010-0319-9