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Type I Polyketide Synthases May Have Evolved Through Horizontal Gene Transfer

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Abstract

Type I polyketide synthases (PKSI) are modular multidomain enzymes involved in the biosynthesis of many natural products of industrial interest. PKSI modules are minimally organized in three domains: ketosynthase (KS), acyltransferase (AT), and acyl carrier protein. The KS domain phylogeny of 23 PKSI clusters was determined. The results obtained suggest that many horizontal transfers of PKSI genes have occurred between actinomycetales species. Such gene transfers may explain the homogeneity and the robustness of the actinomycetales group since gene transfers between closely related species could mimic patterns generated by vertical inheritance. We suggest that the linearity and instability of actinomycetales chromosomes associated with their large quantity of genetic mobile elements have favored such horizontal gene transfers.

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Acknowledgment

We are indebted to the Pôle Bioinformatique Lyonnais for the kind access to their databanks and informatic resources. We gratefully acknowledge Jean-Luc Pernodet and Ludovic Orlando for the fruitful discussions regarding the manuscript. This contribution was supported by European project METACONTROL QLK3-CT-2002-02068.

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  1. LibraGen S.A., Bâtiment Canal Biotech 1, 3 rue des Satellites, 31400, Toulouse, France

    Aurélien Ginolhac, Cyrille Jarrin, Patrick Robe & Renaud Nalin

  2. Ecologie Microbienne, UMR CNRS 5557, Université Claude Bernard, Lyon 1, 43 boulevard du 11 Novembre 1918, 69622, Villeurbanne Cedex, France

    Aurélien Ginolhac, Cyrille Jarrin, Timothy M. Vogel & Pascal Simonet

  3. Laboratoire de Biométrie et Biologie Évolutive, UMR CNRS 5558, Université Claude Bernard, Lyon 1,43 boulevard du 11 Novembre 1918, 69622, Villeurbanne Cedex, France

    Guy Perrière

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  1. Aurélien Ginolhac
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Correspondence to Aurélien Ginolhac.

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Ginolhac, A., Jarrin, C., Robe, P. et al. Type I Polyketide Synthases May Have Evolved Through Horizontal Gene Transfer. J Mol Evol 60, 716–725 (2005). https://doi.org/10.1007/s00239-004-0161-1

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