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Presence of a central vein within white matter lesions on susceptibility weighted imaging: a specific finding for multiple sclerosis?

  • Diagnostic Neuroradiology
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Abstract

Introduction

Susceptibility weighted imaging depicts the perivenous extent of multiple sclerosis white matter lesions (MS-WML) in vivo by directly visualizing their centrally running vein. The aim of this study was to investigate the specificity of this finding for MS.

Methods

Fifteen patients with MS and 15 patients with microangiopathic white matter lesions (mWML) underwent 3T MRI, including a fluid-attenuated inversion recovery sequence (FLAIR) and a susceptibility weighted angiography (SWAN). All WMLs were identified on FLAIR and assigned to one of the following localizations: supratentorial peripheral, supratentorial periventricular, or infratentorial. Subsequently, the presence of a central vein within these lesions was assessed on SWAN.

Results

A total of 711 MS-WMLs and 1,119 m-WMLs were identified on FLAIR, all of which could also be visualized on SWAN. A central vein was detectable in 80% of the MS-WMLs and in 78% of the m-WMLs (in 73% and 76% of the peripheral, in 92% and 94% of the periventricular, and in 71% and 75% of the infratentorial MS-WMLs and m-WMLs, respectively). With regard to the supratentorial peripheral lesions, significantly more m-WMLs showed a central vein compared to the MS-WMLs. For the other localizations, there was no significant difference between the groups with regard to the percentage of lesions with central vein.

Conclusions

Our results indicate that the detection of a central vein within a WML should not be considered a specific finding for MS; it is also found in WMLs of other etiologies.

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Conflict of interest statement

We declare that we have no conflict of interest.

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Authors and Affiliations

  1. Department of Neuroradiology, University of Munich, Marchioninistrasse 15, 81377, Munich, Germany

    Nina Lummel, Tobias Boeckh-Behrens, Veronika Schoepf, Hartmut Brückmann & Jennifer Linn

  2. MR Centre of Excellence, Medical University of Vienna, Vienna, Austria

    Veronika Schoepf

  3. GE Healthcare, Solingen, Germany

    Michael Burke

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  1. Nina Lummel
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  2. Tobias Boeckh-Behrens
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Correspondence to Nina Lummel.

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Lummel, N., Boeckh-Behrens, T., Schoepf, V. et al. Presence of a central vein within white matter lesions on susceptibility weighted imaging: a specific finding for multiple sclerosis?. Neuroradiology 53, 311–317 (2011). https://doi.org/10.1007/s00234-010-0736-z

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  • DOI: https://doi.org/10.1007/s00234-010-0736-z

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