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Molecularly imprinted polymers based on SBA-15 for selective solid-phase extraction of baicalein from plasma samples

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Abstract

Highly selective molecularly imprinted mesoporous silica polymer (SBA-15@MIP) for baicalein (BAI) extraction was synthesized using a surface molecular imprinting technique on the SBA-15 supporter. Computational simulation was used to predict the optimal functional monomer for the rational design of SBA-15@MIP. Meanwhile, high adsorption capacity was obtained when a suitable yield of molecularly imprinted polymers (MIPs) layer was grafted onto the surface of SBA-15. Characterization and performance tests of the obtained polymer revealed that SBA-15@MIP possessed a highly ordered mesoporous structure, reached saturated adsorption within 60 min, and exhibited higher sorption capacity to the target molecule BAI compared with non-imprinted mesoporous silica polymer (SBA-15@NIP) and SBA-15. Finally, SBA-15@MIP was successfully applied to solid-phase extraction (SPE) coupled with high-performance liquid chromatography and ultraviolet detection (HPLC-UV) for the determination of trace BAI in plasma samples. Mean recoveries of BAI through the molecularly imprinted solid-phase extraction (MISPE) sorbent, non-imprinted solid-phase extraction (NISPE) sorbent, and SBA-15 solid-phase extraction (SBA-15-SPE) sorbent were 94.4, 22.7, and 10.7 %, respectively, and the relative standard deviations were 2.9, 2.6, and 3.6 %, respectively. These results reveal that SBA-15@MIP as a SPE sorbent has good applicability to selectively separate and enrich trace BAI from complex samples.

Synthesis procedure of SBA-15@MIP

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Acknowledgment

This work was financially supported by the National Natural Science Foundation of China (Nos. 30801558, 81173538, 21075066, 81373895).

Conflict of interest

The authors have declared no conflict of interest.

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Authors and Affiliations

  1. School of Pharmacy, Nanjing Medical University, Nanjing, 210029, China

    Hongliang He, Xiaoli Gu, Liying Shi, Junli Hong, Hongjuan Zhang, Yankun Gao, Shuhu Du & Lina Chen

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  1. Hongliang He
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  2. Xiaoli Gu
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  3. Liying Shi
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  4. Junli Hong
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  5. Hongjuan Zhang
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  8. Lina Chen
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Correspondence to Lina Chen.

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He, H., Gu, X., Shi, L. et al. Molecularly imprinted polymers based on SBA-15 for selective solid-phase extraction of baicalein from plasma samples. Anal Bioanal Chem 407, 509–519 (2015). https://doi.org/10.1007/s00216-014-8285-7

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  • DOI: https://doi.org/10.1007/s00216-014-8285-7

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