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Ultrafast quantitation of six quinolones in water samples by second-order capillary electrophoresis data modeling with multivariate curve resolution–alternating least squares

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Abstract

This paper presents the development of a capillary electrophoresis method with diode array detector coupled to multivariate curve resolution–alternating least squares (MCR-ALS) to conduct the resolution and quantitation of a mixture of six quinolones in the presence of several unexpected components. Overlapping of time profiles between analytes and water matrix interferences were mathematically solved by data modeling with the well-known MCR-ALS algorithm. With the aim of overcoming the drawback originated by two compounds with similar spectra, a special strategy was implemented to model the complete electropherogram instead of dividing the data in the region as usually performed in previous works. The method was first applied to quantitate analytes in standard mixtures which were randomly prepared in ultrapure water. Then, tap water samples spiked with several interferences were analyzed. Recoveries between 76.7 and 125 % and limits of detection between 5 and 18 μg L−1 were achieved.

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Acknowledgments

The authors are grateful to Universidad Nacional del Litoral (Projects CAI+D 2011 Nos. 11-4, 11-7, and 11-11), to CONICET (Consejo Nacional de Investigaciones Científicas y Técnicas, Project PIP 2012-14 No. 455), and to ANPCyT (Agencia Nacional de Promoción Científica y Tecnológica, Project PICT 2011-0005) for the financial support. M.R.A. thanks CONICET for her fellowship.

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Authors and Affiliations

  1. Laboratorio de Desarrollo Analítico y Quimiometría (LADAQ), Cátedra de Química Analítica I, Facultad de Bioquímica y Ciencias Biológicas, Universidad Nacional del Litoral–CONICET, Ciudad Universitaria, Santa Fe, 3000, Argentina

    Mirta R. Alcaráz, Luciana Vera-Candioti, María J. Culzoni & Héctor C. Goicoechea

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  1. Mirta R. Alcaráz
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  2. Luciana Vera-Candioti
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  3. María J. Culzoni
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  4. Héctor C. Goicoechea
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Correspondence to Héctor C. Goicoechea.

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Alcaráz, M.R., Vera-Candioti, L., Culzoni, M.J. et al. Ultrafast quantitation of six quinolones in water samples by second-order capillary electrophoresis data modeling with multivariate curve resolution–alternating least squares. Anal Bioanal Chem 406, 2571–2580 (2014). https://doi.org/10.1007/s00216-014-7657-3

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  • DOI: https://doi.org/10.1007/s00216-014-7657-3

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