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Milk and serum standard reference materials for monitoring organic contaminants in human samples

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Abstract

Four new Standard Reference Materials (SRMs) have been developed to assist in the quality assurance of chemical contaminant measurements required for human biomonitoring studies, SRM 1953 Organic Contaminants in Non-Fortified Human Milk, SRM 1954 Organic Contaminants in Fortified Human Milk, SRM 1957 Organic Contaminants in Non-Fortified Human Serum, and SRM 1958 Organic Contaminants in Fortified Human Serum. These materials were developed as part of a collaboration between the National Institute of Standards and Technology (NIST) and the Centers for Disease Control and Prevention (CDC) with both agencies contributing data used in the certification of mass fraction values for a wide range of organic contaminants including polychlorinated biphenyl (PCB) congeners, chlorinated pesticides, polybrominated diphenyl ether (PBDE) congeners, and polychlorinated dibenzo-p-dioxin (PCDD) and dibenzofuran (PCDF) congeners. The certified mass fractions of the organic contaminants in unfortified samples, SRM 1953 and SRM 1957, ranged from 12 ng/kg to 2200 ng/kg with the exception of 4,4′-DDE in SRM 1953 at 7400 ng/kg with expanded uncertainties generally <14 %. This agreement suggests that there were no significant biases existing among the multiple methods used for analysis.

Comparison of Concentrations of Selected Compounds in Human Serum and Human Milk Standard Reference Materials (SRMs)

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Acknowledgments

We would like to thank Kim Updegrove (Mothers’ Milk Bank at Austin, Austin, TX) and Pauline Sakomoto (Mothers’ Milk Bank, San Jose, CA) for assistance with acquisition of the milk. Laboratories participating in an interlaboratory study included Institut National de Santé Publique du Québec (Québec, Canada) coordinated by Pierre Dumas and Stockholm University (Stockholm, Sweden) coordinated by Maria Athanasiadou.

Disclaimer

Certain commercial equipment, instruments, or materials are identified in this paper to specify adequately the experimental procedure. Such identification does not imply recommendation or endorsement by the National Institute of Standards and Technology, nor does it imply that the materials or equipment identified are necessarily the best available for the purpose.

Author information

Author notes

  1. Rebecca M. Heltsley

    Present address: Aegis Sciences Corporation, 345 Hill Avenue, Nashville, TN, 37210, USA

  2. Donald G. Patterson Jr

    Present address: EnviroSolutions Consulting, Inc., 4921 Bull Creek Road, Auburn, GA, 30011, USA

Authors and Affiliations

  1. Analytical Chemistry Division, National Institute of Standards and Technology (NIST), 100 Bureau Drive, Gaithersburg, MD, 20899, USA

    Michele M. Schantz, Katherine E. Sharpless & Stephen A. Wise

  2. Mass Spectrometry Laboratory, University of Liège, Allée de la Chimie, 4000, Liège, Belgium

    Gauthier Eppe & Jean-François Focant

  3. AXYS Analytical Services Ltd, 2045 Mills Road West, Sidney, BC, V8L 5X2, Canada

    Coreen Hamilton & Dale Hoover

  4. Statistical Engineering Division, NIST, 100 Bureau Drive, Gaithersburg, MD, 20899, USA

    N. Alan Heckert, Stefan D. Leigh & Adam L. Pintar

  5. Analytical Chemistry Division, NIST, 331 Fort Johnson Road, Charleston, SC, 29412, USA

    Rebecca M. Heltsley, Jennifer M. Keller & Stacy S. Vander Pol

  6. Organic Analytical Toxicology, Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, 4770 Buford Highway, Atlanta, GA, 30341, USA

    Donald G. Patterson Jr, Andreas Sjödin & Wayman E. Turner

Authors
  1. Michele M. Schantz
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Corresponding author

Correspondence to Michele M. Schantz.

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Schantz, M.M., Eppe, G., Focant, JF. et al. Milk and serum standard reference materials for monitoring organic contaminants in human samples. Anal Bioanal Chem 405, 1203–1211 (2013). https://doi.org/10.1007/s00216-012-6524-3

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  • DOI: https://doi.org/10.1007/s00216-012-6524-3

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