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Iron topochemistry and surface reactivity of amphibole asbestos: relations with in vitro toxicity

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Abstract

Chemical reactivity of asbestos tremolite from Italy and USA localities and Union Internationale Contre le Cancer (UICC) crocidolite was studied in relation to Fe content, oxidation state, and structural coordination. Direct correlation between amount of Fe2+ at the exposed M(1) and M(2) sites of the amphibole structure and fiber chemical reactivity was established. The in vitro toxicity of the same samples was investigated on human alveolar A549 cell line. Relationship between crystal-chemical features and cell toxicity is not straightforward. UICC crocidolite has Fe content and chemical reactivity largely higher than that of tremolite samples, but all show comparable in vitro toxic potential. Results obtained evidenced that Fe topochemistry is not a primary factor for induced cell toxicity, though it accounts for asbestos chemical reactivity (and possibly genotoxicity).

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Authors and Affiliations

  1. Dipartimento di Scienze della Terra, Sapienza Università di Roma, Piazzale Aldo Moro 5, 00185, Rome, Italy

    Alessandro Pacella & Giovanni B. Andreozzi

  2. UPMC Paris VI, UMR 7197, Laboratoire de Réactivité de Surface, “Le St Raphaël”, 3, rue Galilée, Ivry-Sur-Seine, 94200, Paris, France

    Jeanine Fournier & Lorenzo Stievano

  3. Institut Charles Gerhardt-AIME, UMR CNRS 5253, Université Montpellier 2, 34095, Montpellier, France

    Lorenzo Stievano

  4. Dipartimento di Scienze Cliniche e Molecolari, Universita’ Politecnica delle Marche, via Tronto n10/A, 60020, Torrette (Ancona), Italy

    Federica Giantomassi, Guendalina Lucarini, Maria Rita Rippo & Armanda Pugnaloni

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  1. Alessandro Pacella
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  2. Giovanni B. Andreozzi
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Correspondence to Alessandro Pacella.

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Pacella, A., Andreozzi, G.B., Fournier, J. et al. Iron topochemistry and surface reactivity of amphibole asbestos: relations with in vitro toxicity. Anal Bioanal Chem 402, 871–881 (2012). https://doi.org/10.1007/s00216-011-5525-y

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  • DOI: https://doi.org/10.1007/s00216-011-5525-y

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