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Two threshold levels of vitamin D and the prevalence of comorbidities in outpatients of a tertiary hospital

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Abstract

Summary

This study evaluated the number of comorbidities between two normal values of 25OHD in outpatients during 1 year of 25OHD measurements. Five hundred twenty-nine outpatients were included, patients with 25OHD ≥ 20 and < 30 ng/mL had the higher number of comorbidities, suggesting that for this specific population, 25OHD ≥ 30 ng/mL would be more appropriate.

Introduction 

This study evaluated the comorbidities between two values of 25OHD in outpatients of a tertiary hospital.

Methods

This is a cross-sectional study with measures of 25OHD in 1-year period, excluding 25OHD < 20 and > 50 ng/mL, clinical research participants, and liver disease and chronic renal failure patients. Patients were divided into two groups: group 1 (G1), 25OHD ≥ 20 and < 30 ng/mL; and group 2 (G2), 250HD ≥ 30 and ≤ 50 ng/mL. Medical records were reviewed for demographic, laboratory, and comorbidity data.

Results

From 529 outpatients included, 319 were in G1 (53.3 ± 15.8 years, 85% women), mean 25OHD 24.8 ± 2.8 ng/mL; and 210 outpatients in G2 (56.7 ± 16.0 years, 83% women), mean 25OHD was 36.8 ± 4.8 ng/mL. G1 had the higher number of comorbidities, including altered glycemia, dyslipidemia, hypothyroidism, urinary tract diseases, arthropathy, secondary hyperparathyroidism, anemia, and neurological and psychiatric disorders. Osteoporosis and hypothyroidism were more prevalent in G2. After binary logistic regression, the variables age (OR 0.988, CI 0.97–1.00, p = 0.048), osteoporosis (OR 0.54, CI 0.36–0.80, p = 0.003), dyslipidemia (OR 1.61, CI 1.10–2.39, p = 0.015), arthropathy (OR 2.60, CI 1.40–5.10, p = 0.003), anemia (OR 15.41, CI 3.09–280.08, p = 0.008), and neurological and psychiatric diseases (OR 3.78, CI 1.98–7.88, p = 0.001) maintained significance.

Conclusion

Patients with serum 25OHD ≥ 20 and < 30 ng/mL had higher prevalence of comorbidities compared to ≥ 30 ng/mL.

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Authors and Affiliations

  1. Universidade Federal do Paraná, Curitiba, Brazil

    I. N. Furuie, M. J. J. Mauro & S. Petruzziello

  2. Clinical Laboratory Unit, Hospital de Clínicas da Universidade Federal do Paraná, Curitiba, Brazil

    S. C. Riechi

  3. Statistics Department, Universidade Federal do Paraná, Curitiba, Brazil

    R. R. Petterle

  4. Serviço de Endocrinologia e Metabologia do Hospital de Clínicas, da Universidade Federal do Paraná (SEMPR), Curitiba, PR, Brazil

    C. L. Boguszewski & V. Z. C. Borba

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Correspondence to V. Z. C. Borba.

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The study was approved by the research ethics committee (CEP-HC-UFPR), 46017715.0.3001.0096.

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Furuie, I.N., Mauro, M.J.J., Petruzziello, S. et al. Two threshold levels of vitamin D and the prevalence of comorbidities in outpatients of a tertiary hospital. Osteoporos Int 29, 433–440 (2018). https://doi.org/10.1007/s00198-017-4299-2

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