Skip to main content

Advertisement

Log in

The present and future of cardiac arrest care: international experts reach out to caregivers and healthcare authorities

  • Review
  • Published:
Intensive Care Medicine Aims and scope Submit manuscript

Abstract

Purpose

The purpose of this review is to describe the epidemiology of out-of-hospital cardiac arrest (OHCA), disparities in organisation and outcome, recent advances in treatment and ongoing controversies. We also outline the standard of care that should be provided by the critical care specialist and propose future directions for cardiac arrest research.

Methods

Narrative review with contributions from international resuscitation experts.

Results

Although it is recognised that survival rates from OHCA are increasing there is considerable scope for improvement and many countries have implemented national strategies in an attempt to achieve this goal. More resources are required to enable high-quality randomised trials in resuscitation.

Conclusions

Increasing international collaboration should facilitate resuscitation research and knowledge translation. The International Liaison Committee on Resuscitation (ILCOR) has adopted a continuous evidence review process, which facilitate the implementation of resuscitation interventions proven to improve patient outcomes.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1

Reproduced with permission from Resuscitation

Similar content being viewed by others

References

  1. Grasner JT, Lefering R, Koster RW et al (2016) EuReCa ONE-27 Nations, ONE Europe, ONE Registry: a prospective one month analysis of out-of-hospital cardiac arrest outcomes in 27 countries in Europe. Resuscitation 105:188–195

    Article  PubMed  Google Scholar 

  2. Benjamin EJ, Blaha MJ, Chiuve SE et al (2017) Heart disease and stroke statistics-2017 update: a report from the American Heart Association. Circulation 135:e146–e603

    Article  PubMed  PubMed Central  Google Scholar 

  3. Daya MR, Schmicker RH, Zive DM et al (2015) Out-of-hospital cardiac arrest survival improving over time: results from the Resuscitation Outcomes Consortium (ROC). Resuscitation 91:108–115

    Article  PubMed  PubMed Central  Google Scholar 

  4. Girotra S, van Diepen S, Nallamothu BK et al (2016) Regional variation in out-of-hospital cardiac arrest survival in the United States. Circulation 133:2159–2168

    Article  PubMed  PubMed Central  Google Scholar 

  5. Becker LB, Aufderheide TP, Graham R (2015) Strategies to improve survival from cardiac arrest: a report from the Institute of Medicine. JAMA 314:223–224

    Article  PubMed  CAS  Google Scholar 

  6. Nolan JP, Perkins GD, Soar J (2015) Improving survival after out-of-hospital cardiac arrest. BMJ 351:h4989

    Article  PubMed  PubMed Central  Google Scholar 

  7. Wissenberg M, Lippert FK, Folke F et al (2013) Association of national initiatives to improve cardiac arrest management with rates of bystander intervention and patient survival after out-of-hospital cardiac arrest. JAMA 310:1377–1384

    Article  PubMed  CAS  Google Scholar 

  8. Kragholm K, Wissenberg M, Mortensen RN et al (2017) Bystander efforts and 1-year outcomes in out-of-hospital cardiac arrest. N Engl J Med 376:1737–1747

    Article  PubMed  Google Scholar 

  9. Virdi G, Picton S, Fothergill R, Whitbread M (2016) Cardiac arrest annual report: 2015/16. London Ambulance Service, London

    Google Scholar 

  10. Berg KM, Grossestreuer AV, Uber A, Patel PV, Donnino MW (2017) Intubation is not a marker for coma after in-hospital cardiac arrest: a retrospective study. Resuscitation 119:18–20

    Article  PubMed  Google Scholar 

  11. Deakin CD, Fothergill R, Moore F, Watson L, Whitbread M (2014) Level of consciousness on admission to a Heart Attack Centre is a predictor of survival from out-of-hospital cardiac arrest. Resuscitation 85:905–909

    Article  PubMed  Google Scholar 

  12. Nolan JP, Ferrando P, Soar J et al (2016) Increasing survival after admission to UK critical care units following cardiopulmonary resuscitation. Crit Care 20:219

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  13. Andrew E, Nehme Z, Wolfe R, Bernard S, Smith K (2017) Long-term survival following out-of-hospital cardiac arrest. Heart 103:1104–1110

    Article  PubMed  Google Scholar 

  14. Kragholm K, Wissenberg M, Mortensen RN et al (2015) Return to work in out-of-hospital cardiac arrest survivors: a nationwide register-based follow-up study. Circulation 131:1682–1690

    Article  PubMed  Google Scholar 

  15. Lilja G, Nielsen N, Friberg H et al (2015) Cognitive function in survivors of out-of-hospital cardiac arrest after target temperature management at 33 °C versus 36 °C. Circulation 131:1340–1349

    Article  PubMed  Google Scholar 

  16. Lilja G, Nielsen N, Bro-Jeppesen J et al (2018) Return to work and participation in society after out-of-hospital cardiac arrest. Circ Cardiovasc Qual Outcomes 11:e003566

    Article  PubMed  Google Scholar 

  17. Geri G, Dumas F, Bonnetain F et al (2017) Predictors of long-term functional outcome and health-related quality of life after out-of-hospital cardiac arrest. Resuscitation 113:77–82

    Article  PubMed  Google Scholar 

  18. Nichol G, Thomas E, Callaway CW et al (2008) Regional variation in out-of-hospital cardiac arrest incidence and outcome. JAMA 300:1423–1431

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  19. Okubo M, Kiyohara K, Iwami T, Callaway CW, Kitamura T (2017) Nationwide and regional trends in survival from out-of-hospital cardiac arrest in Japan: a 10-year cohort study from 2005 to 2014. Resuscitation 115:120–128

    Article  PubMed  Google Scholar 

  20. Nehme Z, Bernard S, Cameron P et al (2015) Using a cardiac arrest registry to measure the quality of emergency medical service care: decade of findings from the Victorian Ambulance Cardiac Arrest Registry. Circ Cardiovasc Qual Outcomes 8:56–66

    Article  PubMed  Google Scholar 

  21. Sasson C, Magid DJ, Chan P et al (2012) Association of neighborhood characteristics with bystander-initiated CPR. N Engl J Med 367:1607–1615

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  22. Starks MA, Schmicker RH, Peterson ED et al (2017) Association of neighborhood demographics with out-of-hospital cardiac arrest treatment and outcomes: where you live may matter. JAMA Cardiol 2:1110–1118

    Article  PubMed  Google Scholar 

  23. Blewer AL, Ibrahim SA, Leary M et al (2017) Cardiopulmonary resuscitation training disparities in the united states. J Am Heart Assoc 6:e006124

    Article  PubMed  PubMed Central  Google Scholar 

  24. Nuno T, Bobrow BJ, Rogge-Miller KA et al (2017) Disparities in telephone CPR access and timing during out-of-hospital cardiac arrest. Resuscitation 115:11–16

    Article  PubMed  PubMed Central  Google Scholar 

  25. Stiell IG, Wells GA, Field B et al (2004) Advanced cardiac life support in out-of-hospital cardiac arrest. N Engl J Med 351:647–656

    Article  PubMed  CAS  Google Scholar 

  26. Jabre P, Penaloza A, Pinero D et al (2018) Effect of Bag-mask ventilation vs endotracheal intubation during cardiopulmonary resuscitation on neurological outcome after out-of-hospital cardiorespiratory arrest: a randomized clinical trial. JAMA 319:779–787

    Article  PubMed  Google Scholar 

  27. Hasegawa K, Hiraide A, Chang Y, Brown DF (2013) Association of prehospital advanced airway management with neurologic outcome and survival in patients with out-of-hospital cardiac arrest. JAMA 309:257–266

    Article  PubMed  CAS  Google Scholar 

  28. Hagihara A, Hasegawa M, Abe T, Nagata T, Wakata Y, Miyazaki S (2012) Prehospital epinephrine use and survival among patients with out-of-hospital cardiac arrest. JAMA 307:1161–1168

    Article  PubMed  CAS  Google Scholar 

  29. Dumas F, Bougouin W, Geri G et al (2014) Is epinephrine during cardiac arrest associated with worse outcomes in resuscitated patients? J Am Coll Cardiol 64:2360–2367

    Article  PubMed  CAS  Google Scholar 

  30. Kudenchuk PJ, Brown SP, Daya M et al (2016) Amiodarone, lidocaine, or placebo in out-of-hospital cardiac arrest. N Engl J Med 374:1711–1722

    Article  PubMed  CAS  Google Scholar 

  31. Hagihara A, Hasegawa M, Abe T, Nagata T, Nabeshima Y (2014) Physician presence in an ambulance car is associated with increased survival in out-of-hospital cardiac arrest: a prospective cohort analysis. PLoS ONE 9:e84424

    Article  PubMed  PubMed Central  Google Scholar 

  32. Olasveengen TM, Lund-Kordahl I, Steen PA, Sunde K (2009) Out-of hospital advanced life support with or without a physician: effects on quality of CPR and outcome. Resuscitation 80:1248–1252

    Article  PubMed  Google Scholar 

  33. Bottiger BW, Bernhard M, Knapp J, Nagele P (2016) Influence of EMS-physician presence on survival after out-of-hospital cardiopulmonary resuscitation: systematic review and meta-analysis. Crit Care 20:4

    Article  PubMed  PubMed Central  Google Scholar 

  34. Nichol G, Aufderheide TP, Eigel B et al (2010) Regional systems of care for out-of-hospital cardiac arrest: a policy statement from the American Heart Association. Circulation 121:709–729

    Article  PubMed  Google Scholar 

  35. Spaite DW, Bobrow BJ, Stolz U et al (2014) Statewide regionalization of postarrest care for out-of-hospital cardiac arrest: association with survival and neurologic outcome. Ann Emerg Med 64(496–506):e1

    Google Scholar 

  36. Ford AH, Clark T, Reynolds EC et al (2016) Management of cardiac arrest survivors in UK intensive care units: a survey of practice. J Intensive Care Soc 17:117–121

    Article  PubMed  CAS  Google Scholar 

  37. Hasselqvist-Ax I, Riva G, Herlitz J et al (2015) Early cardiopulmonary resuscitation in out-of-hospital cardiac arrest. N Engl J Med 372:2307–2315

    Article  PubMed  CAS  Google Scholar 

  38. Rajan S, Wissenberg M, Folke F et al (2016) Association of bystander cardiopulmonary resuscitation and survival according to ambulance response times after out-of-hospital cardiac arrest. Circulation 134:2095–2104

    Article  PubMed  Google Scholar 

  39. Bobrow BJ, Spaite DW, Vadeboncoeur TF et al (2016) Implementation of a regional telephone cardiopulmonary resuscitation program and outcomes after out-of-hospital cardiac arrest. JAMA Cardiol 1:294–302

    Article  PubMed  Google Scholar 

  40. Ro YS, Shin SD, Lee YJ et al (2017) Effect of dispatcher-assisted cardiopulmonary resuscitation program and location of out-of-hospital cardiac arrest on survival and neurologic outcome. Ann Emerg Med 69(52–61):e1

    Google Scholar 

  41. Wu Z, Panczyk M, Spaite DW et al (2018) Telephone cardiopulmonary resuscitation is independently associated with improved survival and improved functional outcome after out-of-hospital cardiac arrest. Resuscitation 122:135–140

    Article  PubMed  Google Scholar 

  42. Ringh M, Rosenqvist M, Hollenberg J et al (2015) Mobile-phone dispatch of laypersons for CPR in out-of-hospital cardiac arrest. N Engl J Med 372:2316–2325

    Article  PubMed  CAS  Google Scholar 

  43. Holmberg MJ, Vognsen M, Andersen MS, Donnino MW, Andersen LW (2017) Bystander automated external defibrillator use and clinical outcomes after out-of-hospital cardiac arrest: a systematic review and meta-analysis. Resuscitation 120:77–87

    Article  PubMed  Google Scholar 

  44. Zijlstra JA, Stieglis R, Riedijk F, Smeekes M, van der Worp WE, Koster RW (2014) Local lay rescuers with AEDs, alerted by text messages, contribute to early defibrillation in a Dutch out-of-hospital cardiac arrest dispatch system. Resuscitation 85:1444–1449

    Article  PubMed  Google Scholar 

  45. Claesson A, Backman A, Ringh M et al (2017) Time to delivery of an automated external defibrillator using a drone for simulated out-of-hospital cardiac arrests vs emergency medical services. JAMA 317:2332–2334

    Article  PubMed  PubMed Central  Google Scholar 

  46. Wang HE, Prince DK, Stephens SW et al (2016) Design and implementation of the Resuscitation Outcomes Consortium Pragmatic Airway Resuscitation Trial (PART). Resuscitation 101:57–64

    Article  PubMed  PubMed Central  Google Scholar 

  47. Taylor J, Black S, Brett SJ et al (2016) Design and implementation of the AIRWAYS-2 trial: a multi-centre cluster randomised controlled trial of the clinical and cost effectiveness of the i-gel supraglottic airway device versus tracheal intubation in the initial airway management of out of hospital cardiac arrest. Resuscitation 109:25–32

    Article  PubMed  Google Scholar 

  48. Olasveengen TM, Sunde K, Brunborg C, Thowsen J, Steen PA, Wik L (2009) Intravenous drug administration during out-of-hospital cardiac arrest: a randomized trial. JAMA 302:2222–2229

    Article  PubMed  Google Scholar 

  49. Jacobs IG, Finn JC, Jelinek GA, Oxer HF, Thompson PL (2011) Effect of adrenaline on survival in out-of-hospital cardiac arrest: a randomised double-blind placebo-controlled trial. Resuscitation 82:1138–1143

    Article  PubMed  CAS  Google Scholar 

  50. Loomba RS, Nijhawan K, Aggarwal S, Arora RR (2015) Increased return of spontaneous circulation at the expense of neurologic outcomes: is prehospital epinephrine for out-of-hospital cardiac arrest really worth it? J Crit Care 30:1376–1381

    Article  PubMed  Google Scholar 

  51. Perkins GD, Quinn T, Deakin CD et al (2016) Pre-hospital assessment of the role of adrenaline: measuring the effectiveness of drug administration in cardiac arrest (PARAMEDIC-2): trial protocol. Resuscitation 108:75–81

    Article  PubMed  PubMed Central  Google Scholar 

  52. Gates S, Quinn T, Deakin CD, Blair L, Couper K, Perkins GD (2015) Mechanical chest compression for out of hospital cardiac arrest: systematic review and meta-analysis. Resuscitation 94:91–97

    Article  PubMed  Google Scholar 

  53. Soar J, Nolan JP, Bottiger BW et al (2015) European resuscitation council guidelines for resuscitation 2015: section 3. Adult advanced life support. Resuscitation 95:100–147

    Article  PubMed  Google Scholar 

  54. Ouweneel DM, Schotborgh JV, Limpens J et al (2016) Extracorporeal life support during cardiac arrest and cardiogenic shock: a systematic review and meta-analysis. Intensive Care Med 42:1922–1934

    Article  PubMed  PubMed Central  Google Scholar 

  55. Nolan JP, Sandroni C (2017) In this patient in refractory cardiac arrest should I continue CPR for longer than 30 min and if so, how? Intensive Care Med 43:1501–1503

    Article  PubMed  Google Scholar 

  56. Abrams D, Garan AR, Abdelbary A et al (2018) Position paper for the organization of ECMO programs for cardiac failure in adults. Intensive Care Med. https://doi.org/10.1007/s00134-018-5064-5

    Article  PubMed  Google Scholar 

  57. Nolan JP, Soar J, Cariou A et al (2015) European Resuscitation Council and European Society of Intensive Care Medicine 2015 guidelines for post-resuscitation care. Intensive Care Med 41:2039–2056

    Article  PubMed  Google Scholar 

  58. Yannopoulos D, Bartos JA, Raveendran G et al (2017) Coronary artery disease in patients with out-of-hospital refractory ventricular fibrillation cardiac arrest. J Am Coll Cardiol 70:1109–1117

    Article  PubMed  Google Scholar 

  59. Deye N, Cariou A, Girardie P et al (2015) Endovascular versus external targeted temperature management for patients with out-of-hospital cardiac arrest: a randomized, controlled study. Circulation 132:182–193

    Article  PubMed  Google Scholar 

  60. Storm C, Nee J, Sunde K et al (2017) A survey on general and temperature management of post cardiac arrest patients in large teaching and university hospitals in 14 European countries—the SPAME trial results. Resuscitation 116:84–90

    Article  PubMed  Google Scholar 

  61. Bray JE, Stub D, Bloom JE et al (2017) Changing target temperature from 33 °C to 36 °C in the ICU management of out-of-hospital cardiac arrest: a before and after study. Resuscitation 113:39–43

    Article  PubMed  Google Scholar 

  62. Kirkegaard H, Soreide E, de Haas I et al (2017) Targeted temperature management for 48 vs 24 hours and neurologic outcome after out-of-hospital cardiac arrest: a randomized clinical trial. JAMA 318:341–350

    Article  PubMed  PubMed Central  Google Scholar 

  63. Chan PS, Berg RA, Tang Y, Curtis LH, Spertus JA, American Heart Association’s Get With the Guidelines-Resuscitation I (2016) Association between therapeutic hypothermia and survival after in-hospital cardiac arrest. JAMA 316:1375–1382

    Article  PubMed  PubMed Central  Google Scholar 

  64. Roberts BW, Kilgannon JH, Hunter BR et al (2018) Association between early hyperoxia exposure after resuscitation from cardiac arrest and neurological disability: a prospective multi-center protocol-directed cohort study. Circulation 137:2114–2124

    Article  PubMed  Google Scholar 

  65. Stub D, Smith K, Bernard S et al (2015) Air versus oxygen in ST-segment-elevation myocardial infarction. Circulation 131:2143–2150

    Article  PubMed  CAS  Google Scholar 

  66. Hofmann R, James SK, Jernberg T et al (2017) Oxygen therapy in suspected acute myocardial infarction. N Engl J Med 377:1240–1249

    Article  PubMed  CAS  Google Scholar 

  67. Pynnonen L, Falkenbach P, Kamarainen A, Lonnrot K, Yli-Hankala A, Tenhunen J (2011) Therapeutic hypothermia after cardiac arrest—cerebral perfusion and metabolism during upper and lower threshold normocapnia. Resuscitation 82:1174–1179

    Article  PubMed  Google Scholar 

  68. Schneider AG, Eastwood GM, Bellomo R et al (2013) Arterial carbon dioxide tension and outcome in patients admitted to the intensive care unit after cardiac arrest. Resuscitation 84:927–934

    Article  PubMed  Google Scholar 

  69. Vaahersalo J, Bendel S, Reinikainen M et al (2014) Arterial blood gas tensions after resuscitation from out-of-hospital cardiac arrest: associations with long-term neurologic outcome. Crit Care Med 42:1463–1470

    Article  PubMed  Google Scholar 

  70. Eastwood GM, Tanaka A, Bellomo R (2016) Cerebral oxygenation in mechanically ventilated early cardiac arrest survivors: the impact of hypercapnia. Resuscitation 102:11–16

    Article  PubMed  Google Scholar 

  71. Eastwood GM, Schneider AG, Suzuki S et al (2016) Targeted therapeutic mild hypercapnia after cardiac arrest: a phase II multi-centre randomised controlled trial (the CCC trial). Resuscitation 104:83–90

    Article  PubMed  Google Scholar 

  72. Beitler JR, Ghafouri TB, Jinadasa SP et al (2017) Favorable neurocognitive outcome with low tidal volume ventilation after cardiac arrest. Am J Respir Crit Care Med 195:1198–1206

    Article  PubMed  PubMed Central  Google Scholar 

  73. Ameloot K, Genbrugge C, Meex I et al (2015) An observational near-infrared spectroscopy study on cerebral autoregulation in post-cardiac arrest patients: time to drop ‘one-size-fits-all’ hemodynamic targets? Resuscitation 90:121–126

    Article  PubMed  CAS  Google Scholar 

  74. Ameloot K, Meex I, Genbrugge C et al (2015) Hemodynamic targets during therapeutic hypothermia after cardiac arrest: a prospective observational study. Resuscitation 91:56–62

    Article  PubMed  CAS  Google Scholar 

  75. Lemiale V, Dumas F, Mongardon N et al (2013) Intensive care unit mortality after cardiac arrest: the relative contribution of shock and brain injury in a large cohort. Intensive Care Med 39:1972–1980

    Article  PubMed  Google Scholar 

  76. Paul M, Bougouin W, Dumas F et al (2018) Comparison of two sedation regimens during targeted temperature management after cardiac arrest. Resuscitation. https://doi.org/10.1016/j.resuscitation.2018.03.025

    Article  PubMed  Google Scholar 

  77. Paul M, Bougouin W, Geri G et al (2016) Delayed awakening after cardiac arrest: prevalence and risk factors in the Parisian registry. Intensive Care Med 42:1128–1136

    Article  PubMed  CAS  Google Scholar 

  78. Bartolo M, Bargellesi S, Castioni CA et al (2017) Mobilization in early rehabilitation in intensive care unit patients with severe acquired brain injury: an observational study. J Rehabil Med 49:715–722

    Article  PubMed  Google Scholar 

  79. Nolan JP, Berg RA, Bernard S et al (2017) Intensive care medicine research agenda on cardiac arrest. Intensive Care Med 43:1282–1293

    Article  PubMed  Google Scholar 

  80. Kleinman ME, Perkins GD, Bhanji F et al (2018) ILCOR scientific knowledge gaps and clinical research priorities for cardiopulmonary resuscitation and emergency cardiovascular care: a consensus statement. Resuscitation 127:132–146

    Article  PubMed  Google Scholar 

  81. Coute RA, Panchal AR, Mader TJ, Neumar RW (2017) National institutes of health-funded cardiac arrest research: a 10-year trend analysis. J Am Heart Assoc 6:e005239

    Article  PubMed  PubMed Central  Google Scholar 

  82. Buick JE, Drennan IR, Scales DC et al (2018) Improving temporal trends in survival and neurological outcomes after out-of-hospital cardiac arrest. Circ Cardiovasc Qual Outcomes 11:e003561

    Article  PubMed  Google Scholar 

  83. van Belle G, Mentzelopoulos SD, Aufderheide T, May S, Nichol G (2015) International variation in policies and practices related to informed consent in acute cardiovascular research: results from a 44 country survey. Resuscitation 91:76–83

    Article  PubMed  Google Scholar 

  84. Mentzelopoulos SD, Bossaert L, Raffay V et al (2016) A survey of key opinion leaders on ethical resuscitation practices in 31 European countries. Resuscitation 100:11–17

    Article  PubMed  Google Scholar 

  85. Nichol G, Powell J, van Ottingham L et al (2006) Consent in resuscitation trials: benefit or harm for patients and society? Resuscitation 70:360–368

    Article  PubMed  Google Scholar 

  86. Nichol G, Leroux B, Wang H et al (2015) Trial of continuous or interrupted chest compressions during CPR. N Engl J Med 373:2203–2214

    Article  PubMed  CAS  Google Scholar 

  87. Flight L, Julious SA, Goodacre S (2017) Can emergency medicine research benefit from adaptive design clinical trials? Emerg Med J 34:243–248

    Article  PubMed  Google Scholar 

  88. Emerson SS, Fleming TR (2010) Adaptive methods: telling “the rest of the story”. J Biopharm Stat 20:1150–1165

    Article  PubMed  Google Scholar 

  89. Laptook AR, Shankaran S, Tyson JE et al (2017) Effect of therapeutic hypothermia initiated after 6 hours of age on death or disability among newborns with hypoxic-ischemic encephalopathy: a randomized clinical trial. JAMA 318:1550–1560

    Article  PubMed  PubMed Central  Google Scholar 

  90. Frobert O, Lagerqvist B, Olivecrona GK et al (2013) Thrombus aspiration during ST-segment elevation myocardial infarction. N Engl J Med 369:1587–1597

    Article  PubMed  CAS  Google Scholar 

  91. James S, Rao SV, Granger CB (2015) Registry-based randomized clinical trials—a new clinical trial paradigm. Nat Rev Cardiol 12:312–316

    Article  PubMed  Google Scholar 

  92. Lauer MS, D’Agostino RB Sr (2013) The randomized registry trial—the next disruptive technology in clinical research? N Engl J Med 369:1579–1581

    Article  PubMed  CAS  Google Scholar 

  93. Nichol G, Brown SP, Perkins GD et al (2016) What change in outcomes after cardiac arrest is necessary to change practice? Results of an international survey. Resuscitation 107:115–120

    Article  PubMed  Google Scholar 

  94. Booth CM, Eisenhauer EA (2012) Progression-free survival: meaningful or simply measurable? J Clin Oncol 30:1030–1033

    Article  PubMed  Google Scholar 

  95. Dancey JE, Dodd LE, Ford R et al (2009) Recommendations for the assessment of progression in randomised cancer treatment trials. Eur J Cancer 45:281–289

    Article  PubMed  CAS  Google Scholar 

  96. Gaudry S, Messika J, Ricard JD et al (2017) Patient-important outcomes in randomized controlled trials in critically ill patients: a systematic review. Ann Intensive Care 7:28

    Article  PubMed  PubMed Central  Google Scholar 

  97. Haywood K, Whitehead L, Nadkarni VM et al (2018) COSCA (Core Outcome Set for Cardiac Arrest) in adults an advisory statement from the International Liaison Committee on resuscitation. Resuscitation 127:147–163

    Article  PubMed  Google Scholar 

  98. Ji C, Lall R, Quinn T et al (2017) Post-admission outcomes of participants in the PARAMEDIC trial: a cluster randomised trial of mechanical or manual chest compressions. Resuscitation 118:82–88

    Article  PubMed  CAS  Google Scholar 

  99. Agarwal S, Presciutti A, Roth W et al (2018) Determinants of long-term neurological recovery patterns relative to hospital discharge among cardiac arrest survivors. Crit Care Med 46:e141–e150

    Article  PubMed  Google Scholar 

  100. Grimshaw JM, Eccles MP, Lavis JN, Hill SJ, Squires JE (2012) Knowledge translation of research findings. Implement Sci 7:50

    Article  PubMed  PubMed Central  Google Scholar 

  101. Perkins GD, Neumar R, Monsieurs KG et al (2017) The International Liaison Committee on resuscitation—review of the last 25 years and vision for the future. Resuscitation 121:104–116

    Article  PubMed  Google Scholar 

  102. Norton WE, McCannon CJ, Schall MW, Mittman BS (2012) A stakeholder-driven agenda for advancing the science and practice of scale-up and spread in health. Implement Sci 7:118

    Article  PubMed  PubMed Central  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Jerry P. Nolan.

Ethics declarations

Conflicts of interest

JPN: Editor-in-Chief, Resuscitation; funding from the National Institute for Health Research to evaluate interventions in cardiac arrest including airway management (AIRWAYS-2 Study) and adrenaline (PARAMEDIC-2 Study). RAB: None declared. CC: None declared. LJM: None declared. VN: None declared. GDP: Funding from the National Institute for Health Research to evaluate interventions in cardiac arrest including mechanical CPR and adrenaline (PARAMEDIC-2 Study). CS: None declared. MS: Research grant from GE Healthcare, travel reimbursements and lecture fees from COVIDIEN, Astellas Pharma, Axis-Shield and BARD. JS: Editor, Resuscitation. KS: None declared. AC: Speakers fees and travel grants from Bard Medical.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Nolan, J.P., Berg, R.A., Callaway, C.W. et al. The present and future of cardiac arrest care: international experts reach out to caregivers and healthcare authorities. Intensive Care Med 44, 823–832 (2018). https://doi.org/10.1007/s00134-018-5230-9

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00134-018-5230-9

Keywords

Navigation