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Hyperglykämie im Kindes- und Jugendalter

Hyperglycemia in children and adolescents

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Zusammenfassung

Die einfache Verfügbarkeit der Blutzuckermessung im medizinischen Alltag führt nicht selten zur Entdeckung hyperglykämischer Zustände, deren Wertigkeit für die Zukunft ohne Zusatzuntersuchungen oft nicht zu beurteilen ist. Obwohl die Prävalenz der Zufalls- und Stresshyperglykämien mit bis zu 4–5% in Abteilungen mit pädiatrischen Notaufnahmen nicht gering ist, scheint nur ein kleiner Anteil dieser Kinder in der Folge an einem Diabetes zu erkranken oder sich bereits in einem prädiabetischen Stadium zu befinden. Dennoch können sich sowohl ein Diabetes mellitus Typ 1 als auch Typ 2 als auch seltenere spezifische Diabetesformen auf diese Weise präsentieren. Eine differenzialdiagnostische Abklärung ist trotz der niedrigen Prävalenz der Zufallshyperglykämie sinnvoll, um einerseits schwere Diabetesmanifestationen, wie eine diabetische Ketoazidose, in der Folge zu verhindern bzw. eine mögliche alternative Therapieform mit Sulfonylharnstoff bei monogenetischen Diabetesformen anzubieten und den weiteren Verlauf zu prognostizieren.

Abstract

The ready availability of blood glucose measurement devices in everyday medical life often leads to the incidental discovery of hyperglycemic events, the long-term significance of which often remains unevaluated in the absence of additional tests. Although up to 4%–5% of children admitted to pediatric accident and emergency units present with transient hyperglycemia, only a minority of these subsequently develops diabetes or is already in a prediabetic stage. Both type 1 and type 2 diabetes, as well as rarer monogenetic forms of diabetes, can present as incidental hyperglycemia. Despite low incidence rates, a differential diagnostic work-up of incidental hyperglycemia is useful, since it may prevent severe diabetic events such as diabetic ketoacidosis; moreover, in the case of specific types of monogenetic diabetes, patients can use oral antidiabetic drugs and the further disease course can be predicted.

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Literatur

  1. ADA (2007) Diagnosis and classification of diabetes mellitus. Diabetes Care 30:S42–S47

    Article  Google Scholar 

  2. Bhisitkul DM, Morrow AL, Vinik AI et al (1994) Prevalence of stress hyperglycemia among patients attending a pediatric emergency department. J Pediatr 244:547–551

    Google Scholar 

  3. Brufani C, Ciampalini P, Grossi A et al (2009) Glucose tolerance status in 510 children and adolescents attending an obesity clinic in central Italy. Pediatr Diabetes April 30. [Epub ahead of print]

  4. Capes SE, Hunt D, Malberg K, Gerstein HC (2000) Stress hyperglycemia and increased risk of death after myocardial infarction in patients with and without diabetes: a systematic overview. Lancet 355:773–778

    Article  CAS  PubMed  Google Scholar 

  5. Codner E, Rocha A, Deng L et al (2009) Mild fasting hyperglycemia in children: high rate of glucokinase mutations and some risk of developing type 1 diabetes mellitus. Pediatr Diabetes 10:382–388

    Article  CAS  PubMed  Google Scholar 

  6. Dungan KM, Braithwaite SS, Preiser JC (2009) Stress hyperglycaemia. Lancet 373:1798–1807

    Article  CAS  PubMed  Google Scholar 

  7. Faustino EV, Apkon M (2005) Persitent hyperglycemia in critically ill children. J Pediatr 146:30–34

    Article  PubMed  Google Scholar 

  8. Feigerlová E, Pruhová S, Dittertová L et al (2006) Aetiological heterogeneity of asymptomatic hyperglycaemia in children and adolescents. Eur J Pediatr 165:446–452

    Article  PubMed  Google Scholar 

  9. Gauglitz GG, Herndon DN, Kulp GA et al (2009) Abnormal insulin sensitivity persists up to three years in pediatric patients post-burn. J Clin Endocrinol Metab 94:1656–1664

    Article  CAS  PubMed  Google Scholar 

  10. Gupta P, Natarajan G, Argarwai KN (1997) Transient hyperglycemia in acute childhood illnesses: to attend or to ignore? Indian J Pediatr 64:205–210

    Article  CAS  PubMed  Google Scholar 

  11. Herskowitz-Dumont R, Wolfsdorf JI, Jackson RA, Eisenbarth GS (1993) Distinction between transient hyperglycemia and early insulin-dependent diabetes mellitus in childhood: a prospective study of incidence and prognostic factors. J Pediatr 123:347–354

    Article  CAS  PubMed  Google Scholar 

  12. Ingenosi C, Caruso-Nicolettti M, D’Amato E et al (2008) Hyperglycemia in celiac disease. Not always pretype 1 diabetes? Pediatr Diabetes 9:335–337

    Article  Google Scholar 

  13. Lorini R, Alibrand A, Vitali L et al (2001) Risk of type1 diabetes development in children with incidental hyperglycemia. Diabetes Care 24:1210–1216

    Article  CAS  PubMed  Google Scholar 

  14. Lowas SR, Marks D, Malempati S (2009) Prevalence of transient hyperglycemia during induction chemotherapy for pediatric acute lymphoblastic leukemia. Pediatr Blood Cancer 52:814–818

    Article  PubMed  Google Scholar 

  15. Mazze RS, Strock E, Wesley D et al (2008) Characterizing glucose exposure for individuals with normal glucose tolerance using continuous glucose monitoring and ambulatory glucose profile analysis. Diabetes Technol Ther 10:149–159

    Article  CAS  PubMed  Google Scholar 

  16. Nasr VG, Dagher WI, Bakara AS (2008) Iatrogenic severe hyperglycemia in a child undergoing adenoidectomy and tonsillectomy. Pediatr Anesth 18:1002–1003

    Article  Google Scholar 

  17. Pawlowicz M, Birkholz D, Niezwiecki M, Balcerska A (2009) Difficulties or mistakes in diagnosing type 1 diabetes in children? Demographic factors influencing delayed diagnosis. Pediatr Diabetes 10(8):542–549

    Article  PubMed  Google Scholar 

  18. Piche ME, Arcand-Bosse JF, Despres JP et al (2004) What is a normal glucose value. Diabetes Care 27:2470–2477

    Article  CAS  PubMed  Google Scholar 

  19. Prokai A, Fekete A, Kis E et al (2008) Post-transplant diabetes mellitus in children following renal transplantation. Pediatr Transplant 12:643–649

    Article  CAS  PubMed  Google Scholar 

  20. Ronan A, Azad AK, Rahman O et al (1997) Hyperglycemia during childhood diarrhea. J Pediatr 130:45–51

    Article  CAS  PubMed  Google Scholar 

  21. Schatz DA, Kowa H, Winter WE, Riley WJ (1989) Natural history of incidental hyperglycemia and glucosuria of childhood. J Pediatr 115:676–680

    Article  CAS  PubMed  Google Scholar 

  22. Shehadeh N, On A, Kessel I et al (1997) Stress hyperglycemia and the risk for the development of type 1 diabetes. J Pediatr Endocrinol Metab 10:283–286

    CAS  PubMed  Google Scholar 

  23. Sonabend RY, McKay SV, Okcu MF et al (2009) Hyperglycemia during induction therapy is associated with poorer survival in children with acute lymphocytic leukemia. J Pediatr 155:73–78

    Article  PubMed  Google Scholar 

  24. Valerio G, Franzese A, Carlin E et al (2001) High prevalence of stress hyperglycemia in children with febrile seizures and traumatic injuries. Acta Paediatr 90:618–622

    Article  CAS  PubMed  Google Scholar 

  25. Vanelli M (2008) Available tools for primary ketoacidosis prevention at diabetes diagnosis in children and adolescents.“The Parma Campaign“. Acta Biomed 79:3–8

    Google Scholar 

  26. Van Hooff JP, Christians MHL, Duijnhoven EM van (2004) Evaluating mechanisms of post-transplant diabetes mellitus. Nephrol Dial Transplant [Suppl 6] 19:vi8–vi12

    Google Scholar 

  27. Vlasselaers D, Milants I, Desmet L et al (2009) Intensive insulin therapy for patients in paediatric intensive care: a prospective, randomised controlled study. Lancet 373:547–556

    Article  CAS  PubMed  Google Scholar 

  28. Waseem M, Narasimhan M, Ganti S (2008) A child with abdominal pain and hyperglycemia: is it diabetic ketoacidosis? Pediatr Emerg Care 24:39–40

    Article  PubMed  Google Scholar 

  29. Wintergerst KA, Buckingham B, Gandrud L et al (2006) Association of hypoglycaemia, hyperglycemia and glucose variability with morbidity and death in the pediatric intensive care unit. Pediatrics 118:173–179

    Article  PubMed  Google Scholar 

  30. Yates AR, Dyke PC, Taeed R et al (2006) Hyperglycemia is a marker for poor outcome in the postoperative pediatric cardiac patient. Pediatr Crit Care Med 7:351–355

    Article  PubMed  Google Scholar 

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Schober, E., Rami, B. Hyperglykämie im Kindes- und Jugendalter. Monatsschr Kinderheilkd 158, 281–289 (2010). https://doi.org/10.1007/s00112-009-2114-7

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