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Plattenepithelkarzinom als das häufigste Mundhöhlenkarzinom

Diagnostik und Therapie

Squamous cell carcinoma as the most common oral carcinoma

Diagnosis and therapy

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Zusammenfassung

Hintergrund

Etwa 5 % aller malignen Tumoren betreffen die Mundhöhle. Mit einem Anteil von 95 % handelt es sich bei den bösartigen Tumoren der Mundhöhle überwiegend um Plattenepithelkarzinome.

Fallbericht

In unserem Fall entwickelte die Patientin ca. 2 Jahren nach der Exzision einer verrukösen Leukoplakie mit Epitheldysplasien ein Plattenepithelkarzinom der Mundhöhle an der gleichen Lokalisation. Obwohl chronischer Alkoholabusus, Tabakkonsum und eine Infektion mit HPV 16 zu den wichtigsten Risikofaktoren für die Entwicklung eines Plattenepithelkarzinoms der Mundhöhle zählen, hat unsere Patientin keines von diesen Kriterien erfüllt. Wir therapierten leitliniengemäß mit einer Exzision des Tumors in toto sowie einer elektiven Neck-dissection der ipsilateralen Seite. Bis zum aktuellen Zeitpunkt ist die Patientin rezidivfrei.

Schlussfolgerung

Auch wenn selten, können Plattenepithelkarzinome der Mundschleimhaut bei Patienten vorkommen, die keine Risikofaktoren dafür aufweisen. Daher soll jede zahnärztliche und ärztliche Untersuchung zwecks einer Vorsorge bei jedem Patienten eine Inspektion der gesamten Mundschleimhaut beinhalten.

Abstract

Background

About 5 % of all malignant tumors affect oral cavity. With a share of 95% squamous cell carcinoma is the most common type of the malignant tumors of oral mucosa.

Case report

In our case the patient developed a squamous cell carcinoma of buccal mucosa about 2 years after excision of verrucous leukoplakia with epithelial dysplasia at the same location. Although chronic alcohol abuse, tobacco use and infection with HPV 16 are the most important risk factors for development of squamous cell carcinoma of the oral cavity, our patient had none of these risk factors. We treated the patient in accordance with current guidelines by complete excision of the tumor as well as an elective neck dissection of the ipsilateral side. Untill the present time the patient is free of recurrence.

Conclusions

Although rare, squamous cell carcinoma of oral mucosa may also occur in patients that have no risk factors for it. Therefore, every dental and medical examination in each patient should include an inspection of the entire oral mucosa.

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Einhaltung ethischer Richtlinien

Interessenkonflikt. G. Balakirski, F. Hölzle und M. Megahed geben an, dass kein Interessenkonflikt besteht. Dieser Beitrag beinhaltet keine Studien an Menschen oder Tieren.

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Authors and Affiliations

  1. Klinik für Dermatologie und Allergologie, Universitätsklinikum der RWTH Aachen, Pauwelsstr. 30, 52074, Aachen, Deutschland

    G. Balakirski & M. Megahed

  2. Klinik für Mund-, Kiefer- und Gesichtschirurgie, Universitätsklinikum der RWTH Aachen, Aachen, Deutschland

    F. Hölzle

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  1. G. Balakirski
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  2. F. Hölzle
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  3. M. Megahed
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Correspondence to G. Balakirski.

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Balakirski, G., Hölzle, F. & Megahed, M. Plattenepithelkarzinom als das häufigste Mundhöhlenkarzinom. Hautarzt 65, 390–392 (2014). https://doi.org/10.1007/s00105-014-2790-7

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  • DOI: https://doi.org/10.1007/s00105-014-2790-7

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