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CD30(+) ALK(−) anaplastisch großzelliges primär kutanes T-Zell-Lymphom

Primary cutaneous CD30(+) ALK(−) anaplastic large cell T-cell lymphoma

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Zusammenfassung

Anaplastisch großzellige Lymphome sind durch große, pleomorphe Zellen und starke Expressivität des Zytokinrezeptors CD30 gekennzeichnet. Wir berichten über einen 71-jährigen Patienten mit mehreren Tumorknoten im Bereich der rechten Schläfe und des rechten Ohransatzes. Anhand klinischer, histologischer und immunphänotypischer Kriterien konnte die Diagnose eines CD30(+) ALK(−) anaplastisch großzelligen primär kutanen T-Zell-Lymphoms gestellt werden. Nach lokaler Exzision der Tumorknoten und adjuvanter Radiotherapie zeigte sich in einem Follow-up von 3 Monaten kein Hinweis für ein Rezidiv.

Abstract

Anaplastic large cell lymphomas (ALCL) are characterized by large, pleomorphic cells with a strong expression of cytokine receptor CD 30. We present a 71-year-old patient with several nodules on the right temple extending to his right ear. Based on clinical, histological and immunophenotypic criteria, the diagnosis of a primary cutaneous CD30(+) ALK(−) anaplastic large cell lymphoma was made. After local excision and adjuvant radiotherapy no relapse occurred during a follow-up period of three months.

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Mühlhoff, C., Rübben, A., Gaßler, N. et al. CD30(+) ALK(−) anaplastisch großzelliges primär kutanes T-Zell-Lymphom. Hautarzt 60, 954–956 (2009). https://doi.org/10.1007/s00105-009-1874-2

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