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Protective effects of three luteolin derivatives on aflatoxin B1-induced genotoxicity on human blood cells

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Abstract

In the present study, we aimed to investigate the genotoxic and anti-genotoxic potencies of three luteolin derivatives (luteolin-7-O-glucoside, luteolin-7-O-rutinoside and luteolin-7-O-glucuronide) by using human cells. In the micronucleus test, the human lymphocytes were exposed to aflatoxin B1, the luteolin derivatives and a mixture of the two for 72 h. Furthermore, we have evaluated the levels of antioxidants of human whole blood plasma in order to clarify the possible mechanisms that may contribute to the anti-genotoxic activity of the luteolin derivatives. According to the results obtained from the micronucleus test, the highest protection rates for luteolin-7-O-glucoside, luteolin-7-O-rutinoside and luteolin-7-O-glucuronide against aflatoxin B1 were 32.09, 35.55 and 37.50 %, respectively. Similarly, these three luteolin derivatives ameliorated the level of antioxidants altered from aflatoxin B1.

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Acknowledgments

This study was supported by The Scientific and Technological Research Council of Turkey

(TUBITAK: 107T203).

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Authors and Affiliations

  1. Central Research and Application Laboratories, Agri Ibrahim Cecen University, Agri, Turkey

    Furkan Orhan & Selçuk Çeker

  2. Faculty of Science, Department of Molecular Biology and Genetics, Ataturk University, Erzurum, Turkey

    Mustafa Anar

  3. Faculty of Science, Department of Biology, Ataturk University, Erzurum, Turkey

    Guleray Agar & Medine Gulluce

  4. Molecular Biology and Genetics, Yıldız Technical University, Istanbul, Turkey

    Tulin Arasoglu

Authors
  1. Furkan Orhan
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  2. Selçuk Çeker
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  3. Mustafa Anar
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  4. Guleray Agar
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  6. Medine Gulluce
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Correspondence to Selçuk Çeker.

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Orhan, F., Çeker, S., Anar, M. et al. Protective effects of three luteolin derivatives on aflatoxin B1-induced genotoxicity on human blood cells. Med Chem Res 25, 2567–2577 (2016). https://doi.org/10.1007/s00044-016-1681-0

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  • DOI: https://doi.org/10.1007/s00044-016-1681-0

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