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Efficient synthesis of heterocyclic compounds derived from 2,6-dioxopiperazine derivatives and their evaluation for anti-inflammatory and anticancer activities

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Abstract

Piperazine dione derivatives (1a–j) on condensation with 2,6-pyridine dicarboxylic acid (2x), 3,5-pyridine dicarboxylic acid (2y) and 2,5-thiophene dicarboxylic acid (2z) gave corresponding heterocyclic compounds 3ax–3jz in excellent yields. All the newly synthesized compounds were fully characterized by spectroscopic means and elemental analysis. On screening for anti-inflammatory and for in vitro anticancer activity, compounds 3bx, 3cx, 3dx, and 3ex exhibited good anti-inflammatory activity, whereas compounds 3ay, 3az, 3cz, 3dx, 3ez, 3fx, 3gx, and 3hz exhibited good anticancer activity.

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Acknowledgments

We are thankful to technical staff of the Chemistry Department, I. I. T. Roorkee, for spectroscopic studies and elemental analysis. Thanks also due to Head I.I.C. for providing NMR facility. Mr. Sandeep Kumar is thankful to MHRD New Delhi for financial assistance.

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Authors and Affiliations

  1. Department of Chemistry, Indian Institute of Technology-Roorkee, Roorkee, 247667, India

    Sandeep Kumar & Sham M. Sondhi

  2. Department of Biotechnology, Indian Institute of Technology-Roorkee, Roorkee, 247667, India

    Nikhil Kumar & Partha Roy

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  1. Sandeep Kumar
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  2. Nikhil Kumar
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  3. Partha Roy
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  4. Sham M. Sondhi
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Correspondence to Sham M. Sondhi.

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Kumar, S., Kumar, N., Roy, P. et al. Efficient synthesis of heterocyclic compounds derived from 2,6-dioxopiperazine derivatives and their evaluation for anti-inflammatory and anticancer activities. Med Chem Res 23, 3953–3969 (2014). https://doi.org/10.1007/s00044-014-0969-1

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