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Modification of C2 functional group on asiatic acid and the evaluation of hepatoprotective effects

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Abstract

For the development of novel hepatoprotective agents, C2 functional group on asiatic acid was modified, and evaluated for their hepatoprotective effects. Among prepared compounds, com-pounds10 and14 showed better hepatoprotective effects compared to Silymarin.

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References

  • Berry, M. N. and Friend D. S., High yields preparation of isolated rat hepatocytes enchymal cells.J. Cell Biol., 43, 506- 520 (1984).

    Article  Google Scholar 

  • Dai, Y, Hang, B. Q., Meng, Q., Ma, S. P., and Tan, L. W., Inhibition of hypersensitivity reactions by oleanolic acid.Acta Pharmacologica Sinica, 9, 562–565 (1988).

    PubMed  CAS  Google Scholar 

  • Dai, Y, Hang, B. Q., and Tan, L. W., Anti-inflammatory effect of oleanolic acid.Chinese J. of Pharmacol. Toxicol., 3, 96–99 (1989a).

    CAS  Google Scholar 

  • Dai, Y, Hang, B. Q., Li, P. Z., and Tan, L. W., Effect of oleanolic acid on immune system and type l allergic reaction.Acta Pharmacologica Sinica, 10, 381–384 (1989b).

    PubMed  CAS  Google Scholar 

  • Elsinger, F.; Schreiber J., and Eschenmoser, A.; Selectivity of the cleavage of methyl esters of carboxylic acids with lithium iodide.Helv. Chim. Acta., 43, 113–118 (1960).

    Article  CAS  Google Scholar 

  • Hao, Z., Hang, B., and Wang, Y, Hypoglycemic effect of oleanolic acid.Zhougguo Yaoke Daxue Xuebao, 22, 210–212 (1989).

    Google Scholar 

  • Hikino, H., Ohsawa, T, Kiso, Y, and Oshima, Y, Analgesic and antihepatotoxic actions of dianosides, triterpenoid saponins of dianthus superbus var logicalycinus herbs.Planta Media, 50, 353–354 (1984).

    Article  CAS  Google Scholar 

  • Liu, J., Liu, Y. P., and Klaassen, C. D., The effect of Chinese hepatoprotective medicines on experimental liver injury in mice.J. Ethanopharmacol., 42, 183–191 (1994).

    Article  CAS  Google Scholar 

  • Ma, X, H., Zhao, Y. C., Yin, L., Han, D. W., and Wan, M. S., Studies on the preventive and therapeutic effects of ursolic acid on acute hepatic injury in rats.Acta Pharmaceutica Sinica, 21, 332–335 (1986).

    PubMed  CAS  Google Scholar 

  • Reitman, S. and Frankel, S. A.,Am. J. Clin. Pathol., 28, 56–63 (1957).

    PubMed  CAS  Google Scholar 

  • Sastri, B. N. (ed.) ‘The Wealth of India, Raw Materials,’ vol. II C.S.I.R., New Delhi, p116 (1950).

    Google Scholar 

  • Shukla, B., Viser, S., Patnaik, G. K., Tripathi, S. C, Srimal, R. C, Day, S., and Dobhal, P. C, Hepatoprotective activity in the rat of ursolic acid isolated fromEucaltptus hybrid.Phytotherapy Res., 6, 74–79 (1992).

    Article  CAS  Google Scholar 

  • Wang, B. and Jiang, Z. H., Studies on oleanolic acid.Chinese Pharmaceutical Journal, 27, 393–397 (1992).

    CAS  Google Scholar 

  • Yabuchi, T., Tanaka, T., Sasatsuka, T., Yamahara, J., and Fujimura, H., Extraction of oleanolic acid from sugar beets for treatment of liver failure.Chem. Abst., 108, 82082p (1988).

    Google Scholar 

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Correspondence to Eung-Seok Lee.

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Jeong, BS., Lee, M.K., Kim, Y.C. et al. Modification of C2 functional group on asiatic acid and the evaluation of hepatoprotective effects. Arch Pharm Res 30, 282–289 (2007). https://doi.org/10.1007/BF02977607

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  • DOI: https://doi.org/10.1007/BF02977607

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