Summary
The incidence of double nuclei in myocarditis and in cases with right ventricular overloading (CRVO) was histopathologically assessed in a minimum of 100 longitudinally cut myocytes in specimens obtained at right ventricular endomyocardial biopsy. In myocarditis, the incidence of double nuclei was shown to be 5.8 ± 1.8 and in CRVO and in normal heart tissue it was seen in 3.0 ± 0.8 and 3.2 ± 0.9% (m±S.D.), respectively, of the population of myocytes. It is concluded that double nuclei result from either the activity or the reparative process of myocarditis and that it is not the expression of chronic right ventricular overloading. It is suggested that quantitative assessment of the frequency of double nuclei is an useful method in the interpretation of myocardial biopsy.
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References
Sekiguchi M, Hiroe M, Morimoto S (1979/1980) On the standardization of histopathological diagnosis and semiquantitative assessment of the endomyocardium obtained by endomyocardial biopsy. Bull Heart Inst Japan, pp 55–85
Yu Z-X, Sekiguchi M, Hiroe M, Take M, Hirosawa K (1984) Histopathological findings of acute and convalescent myocarditis obtained by serial endomyocardial biopsy. Jpn Circul J 48: 1368–1374
Shozawa T, Kawamura K (1980) Double nuclei in the regenerating process of cardiac muscle fibers in experimental diphtheria. In: Sekiguchi M, Olsen EGJ (eds). Cardiomyopathy, clinical, pathological and theoretical aspects. University of Tokyo Press, Tokyo, and University Park Press, Baltimore, pp 185–196
Baroldi G, Falzi G, Lampertico P (1967) The nuclear patterns of the cardiac muscle fiber. Cardiologia 51: 109–123
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This study was supported by a Grant from the Japan Research Promotion Society for Cardiovascular Diseases
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Yu, ZX., Sekiguchi, M., Hasumi, M. et al. Double nuclei in endomyocardial biopsy: A comparative study of the incidence in myocarditis and chronic right ventricular overloading. Heart Vessels 1, 58–59 (1985). https://doi.org/10.1007/BF02066490
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DOI: https://doi.org/10.1007/BF02066490