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Bactericidal activity of daptomycin against vancomycin-resistantEnterococcus faecium in an in vitro pharmacokinetic model

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Abstract

A dynamic in vitro model was used to determine the killing kinetics of daptomycin against 15 vancomycin-resistant clinical isolates ofEnterococcus faecium. Concentration profiles simulating those observed in serum following administration of both low-dose (2 mg/kg) and high-dose (6 mg/kg) daptomycin were bactericidal within 5.5 and 2.8 h, respectively. In contrast, when albumin was added to the growth medium, the corresponding bacterial killing times were slowed to>24 h and 7 h; these results suggest that in the clinical setting, daptomycin dosages of approximately 6 mg/kg are required to achieve bactericidal activity against vancomycin-resistantEnterococcus faecium.

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Authors and Affiliations

  1. Laboratoire de Microbiologie, Hôpital Robert Debré, 48 Bd Sérurier, 75019, Paris, France

    E. Bingen, C. Doit, N. Lambert-Zechovsky, F. Bourgeois & P. Mariani-Kurkdjian

  2. Departement de Pharmacologie-Toxicologie Hospitalière, Hôpital Avicenne, 125 route de Stalingrad, 93000, Bobigny, France

    M. Tod & O. Petitjean

Authors
  1. E. Bingen
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  2. C. Doit
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  3. N. Lambert-Zechovsky
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  4. M. Tod
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  5. O. Petitjean
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  6. F. Bourgeois
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  7. P. Mariani-Kurkdjian
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Bingen, E., Doit, C., Lambert-Zechovsky, N. et al. Bactericidal activity of daptomycin against vancomycin-resistantEnterococcus faecium in an in vitro pharmacokinetic model. Eur. J. Clin. Microbiol. Infect. Dis. 10, 1062–1065 (1991). https://doi.org/10.1007/BF01984930

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