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Δ6-Tetrahydrocannabinol-7-oic acid, a urinary Δ6-THC metabolite: Isolation and synthesis

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Zusammenfassung

7-Hydroxy-Δ 6-tetrahydrocannabinol (7-Hydroxy-Δ 6-THC), ein psychotomimetisch aktiver Metabolit desΔ 6-THC, wird von Kaninchen in inaktiveΔ 6-THC-7 Säure metabolisiert. Die Synthese dieser Säure wird beschrieben.

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Literatur

  1. W. D. M. Paton andJ. Crown,Cannabis and its Derivatives (Oxford University Press, London 1972).

    Google Scholar 

  2. R. Mechoulam,Marijuana. Chemistry, Pharmacology, Metabolism and Clinical Effects (Academic Press, New York 1973).

    Google Scholar 

  3. S. Burstein, J. Rosenfeld andT. Wittstruck, Science176, 422 (1972).

    Article  CAS  PubMed  Google Scholar 

  4. H. Edery, Y. Grunfeld, Z. Ben-Zvi andR. Mechoulam, Ann N.Y. Acad. Sci.191, 40 (1971).

    Article  CAS  Google Scholar 

  5. M. E. Wall, Ann. N.Y. Acad. Sci.191, 23 (1971).

    Article  CAS  Google Scholar 

  6. E. J. Corey, N. W. Gilman andB. E. Ganem, J. Am. chem. Soc.90, 5616 (1968).

    Article  CAS  Google Scholar 

  7. J. L. G. Nilsson, I. M. Nilsson, S. Agurell, Z. Ben-Zvi andR. Mechoulam, Acta pharmac. Suecica9, 215 (1972).

    CAS  Google Scholar 

  8. C. G. Pitt, F. Hauser, R. L. Hawks, S. Sathe andM. E. Wall, J. Am. chem. Soc.94, 8578 (1972).

    Article  CAS  PubMed  Google Scholar 

  9. S. Agurell, inThe Botany and Chemistry of Cannabis (Ed.C. R. B. Joyce andS. H. Curry; J. and A. Churchill, London (1970).

    Google Scholar 

  10. E. Änggård andH. Bergkvist, J. Chromat.48, 542 (1970).

    Article  Google Scholar 

  11. C. G. Hammar andR. Hessling, Analyt. Chem.43, 298 (1971).

    Article  CAS  Google Scholar 

  12. O. Gurny, D. E. Maynard, R. G. Pitcher andR. W. Kierstead, J. Am. chem. Soc.94, 7928 (1972).

    Article  CAS  PubMed  Google Scholar 

  13. R. Mechoulam, H. Varconi, Z. Ben-Zvi, H. Edery andY. Grunfeld, J. Am. chem. Soc.94, 7930 (1972).

    Article  CAS  PubMed  Google Scholar 

  14. E. W. Gill, G. Jones andD. K. Lawrence, Biochem. pharmac.22, 175 (1973).

    Article  CAS  Google Scholar 

  15. L. Lemberger, J. Axelrod andI. J. Kopin, Ann. N.Y. Acad. Sci.191, 142 (1971).

    Article  CAS  Google Scholar 

  16. M. E. Wall, D. R. Brine, C. G. Pitt andM. Perez-Reyes, J. Am. chem. Soc.94, 8579 (1972).

    Article  CAS  PubMed  Google Scholar 

  17. S. Burstein andJ. Rosenfeld, Acta pharmac. Suecica8, 699 (1971).

    Google Scholar 

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Author information

Authors and Affiliations

  1. Department of Natural Products, Hebrew University Pharmacy School, Dept. of Natural Products, P.O. Box 12065, Jerusalem, Israel

    R. Mechoulam, Z. Ben Zvi, S. Agurell, I. M. Nilsson, J. L. G. Nilsson, H. Edery & Y. Grunfeld

  2. Faculty of Pharmacy, Box 6804, S-113 86, Stockholm, Sweden

    R. Mechoulam, Z. Ben Zvi, S. Agurell, I. M. Nilsson, J. L. G. Nilsson, H. Edery & Y. Grunfeld

  3. Isrdel Institute for Biological Research, Medical School, Tel-Aviv University, Ness-Ziona, Israel

    R. Mechoulam, Z. Ben Zvi, S. Agurell, I. M. Nilsson, J. L. G. Nilsson, H. Edery & Y. Grunfeld

Authors
  1. R. Mechoulam
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  2. Z. Ben Zvi
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  3. S. Agurell
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  4. I. M. Nilsson
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  5. J. L. G. Nilsson
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  6. H. Edery
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  7. Y. Grunfeld
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Additional information

The work in Jerusalem was supported by the US National Institute of Mental Health and in Stockholm by the Swedish Medical Research Council.

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Mechoulam, R., Zvi, Z.B., Agurell, S. et al. Δ6-Tetrahydrocannabinol-7-oic acid, a urinary Δ6-THC metabolite: Isolation and synthesis. Experientia 29, 1193–1195 (1973). https://doi.org/10.1007/BF01935065

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  • DOI: https://doi.org/10.1007/BF01935065

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