Resumen
Se hizo un estudio comparativo de la actividad delΔ 9-tetrahidrocannabinol, cannabinol, y cannabidiol en producir efectos similares a la marihuana cuando son inyectados i.v. a humanos. Estas substancias son los componentes predominantes de la marihuana o del hashish. Se encontro que a las dosis inyectados cannabidiol no tiene ninguna potencia, y que cannabinol es capaz de producir efectos tipicos de la marihuana, aunque a dosis varias veces mas grandes que las delΔ 9-tetrahidrocannabinol.
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Literatur
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Acknowledgments. These studies were conducted under Contract No. HSM-42-71-95 between the Center for Studies of Narcotic and Drug Abuse of the Division of Narcotic Addiction and Drugo Abuse, NIMH, and the Research Triangle Institute. In addition, this investigation was supported by Public Health Service Research Grant No. RR-46 from the General Clinical Research Centers Branch of the Division of Research Resources. We thank Drs.Monique Braude andS. Szara, Center for Studies of Narcotic and Drug Abuse, NIMH, for their interest and encouragement of this program. We also thankCarolyn Bishop andDaynise Skeen for their technical assistance.
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Perez-Reyes, M., Timmons, M.C., Davis, K.H. et al. A comparison of the pharmacological activity in man of intravenously administered 1368-11368-11368-1, cannabinol, and cannabidiol. Experientia 29, 1368–1369 (1973). https://doi.org/10.1007/BF01922823
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DOI: https://doi.org/10.1007/BF01922823