Skip to main content
Log in

What is the future for fluoride in the treatment of osteoporosis?

  • Editorial
  • Published:
Osteoporosis International Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

References

  1. Rich C, Ensinck J. Effect of sodium fluoride on calcium metabolism of human beings. Nature 1961;191:184–5.

    Google Scholar 

  2. Kanis JA, Meunier PJ. Should we use fluoride to treat osteoporosis? A review. Q J Med 1984;53:145–64.

    Google Scholar 

  3. Frey H. Fluoride in the treatment of osteoporosis. Acta Med Scand 1986;220:193–4.

    Google Scholar 

  4. Brown EM. Fluoride and the therapy of osteoporosis [editorial]. J Clin Endocrinol Metab 1989;69:929–31.

    Google Scholar 

  5. Hansson T, Roos B. The effect of fluoride and calcium on spinal bone mineral content: a controlled, prospective (3 years) study. Calcif Tissue Int 1987;40:315–7.

    Google Scholar 

  6. Eriksen EF, Hodgson SF, Riggs BL. Treatment of osteoporosis with sodium fluoride. In: Riggs BL, Melton LJ III, editors. Osteoporosis: etiology, diagnosis, and management. New York: Raven Press, 1988:415–32.

    Google Scholar 

  7. Farley SMG, Libanati CR, Mariano-Menez MR, Tudtud-Hans LA, Schulz EE, Baylink DJ. Fluoride therapy for osteoporosis promotes a progressive increase in spinal bone density. J Bone Miner Res 1990;5(Suppl 1):S37–42.

    Google Scholar 

  8. Pouilles JM, Tremollieres F, Causse E, Louvet JP, Ribot C. Fluoride therapy in postmenopausal osteopenic women: effect on vertebral and femoral bone density and prediction of bone response. Osteoporosis Int 1991;1:103–9.

    Google Scholar 

  9. Affinito P, Di Carlo C, Primizia M, Petrillo G, Napolitano V, Tremolaterra F, Nappi C. A new fluoride preparation for the prevention of postmenopausal osteoporosis: calcium monofluorophosphate. Gynecol Endocrinol 1993;7:201–5.

    Google Scholar 

  10. Meys E, Terraux-Duvert F, Beaume-Six T, Dureau G, Meunier PJ. Bone loss after cardiac transplantation: effects of calcium, calcidiol and monofluorophosphate. Osteoporosis Int 1993;3:1–8.

    Google Scholar 

  11. Lane JM, Healey JH, Schwartz E, Vigorita VJ, Schneider R, Einhorn TA, et al. Treatment of osteoporosis with sodium fluoride and calcium: effects on vertebral fracture incidence and bone histomorphometry. Orthop Clin North Am 1984;15:729–45.

    Google Scholar 

  12. Power GRI, Gay JDL. Sodium fluoride in the treatment of osteoporosis. Clin Invest Med 1986;9:41–3.

    Google Scholar 

  13. Riggs BL, Seeman E, Hodgson SF, Taves DR, O'Fallon WM. Effect of the fluoride/calcium regimen on vertebral fracture occurrence in postmenopausal osteoporosis: comparison with conventional therapy. N Engl J Med 1982;306:446–50.

    Google Scholar 

  14. Ringe JD. Monofluorophosphate prevents fractures in postmenopausal osteoporosis. In: Genazzani N, ed. Current research in gynecology and obstetrics. Casterton Hall: Parthenon, 1991:527–31.

    Google Scholar 

  15. Farley JR, Wergedahl JE, Farley JR, Javier GN, Schulz EE, Talbot JR, et al. Spinal fractures during fluoride therapy for osteoporosis: relationship to spinal density. Osteoporosis Int 1992;2:213–8.

    Google Scholar 

  16. Mamelle N, Meunier PJ, Dusan R, Guillaume M, Martin JL, Gaucher A, et al. Risk-benefit ratio of sodium fluoride treatment in primary vertebral osteoporosis. Lancet 1988;II:361–5.

    Google Scholar 

  17. Mamelle N, Meunier PJ, Netter P. Fluoride and vertebral fractures. Lancet 1990;336:243.

    Google Scholar 

  18. Riggs BL, O'Fallon WM, Lane A, Hodgson SF, Wahner HW, Muhs JM, et al. Clinical trial of fluoride therapy in postmenopausal osteoporotic women: extended observations and additional analysis. J Bone Miner Res 1994;9:265–75..

    Google Scholar 

  19. Pak CYC, Sakhaee K, Piziak V, Peterson RD, Breslau NA, Boyd P, et al. Slow-release sodium fluoride in the management of postmenopausal osteoporosis: a randomized controlled trial. Ann Intern Med 1994;120:625–32.

    Google Scholar 

  20. Riggs BL, Hodgson SF, O'Fallon WM, Chao EY, Wahner HW, Muhs JM, et al. Effect of fluoride treatment on the fracture rate in postmenopausal women with osteoporosis. N Engl J Med 1990;322:802–9.

    Google Scholar 

  21. Kleerekoper M, Peterson EL, Nelson DA, Phillips E, Schork MA, Tilley BC, Parfitt AM. A randomized trial of sodium fluoride as a treatment for postmenopausal osteoporosis. Osteoporosis Int 1991;1:155–61.

    Google Scholar 

  22. Consensus development conference. Diagnosis, prophylaxis and treatment of osteoporosis. Am J Med 1993;94:646–50.

    Google Scholar 

  23. Melton LJ, Chrischilles EA, Cooper C, Lane AW, Riggs BL. Perspective. How many women have osteoporosis? Bone Miner Res 1992;7:1005–10.

    Google Scholar 

  24. Pak CYC, Sakhaee K, Gallagher C, Parcel C, Peterson R, Zerwekh JE, et al. Attainment of therapeutic fluoride levels in serum without major side effects using a slow-release preparation of sodium fluoride in postmenopausal osteoporosis. J Bone Miner Res 1986;1:563–71.

    Google Scholar 

  25. Müller P, Simon B, Schmid K, Warnecke G, Setnikar I. Gastric effects of sodium fluoride: comparison with sodium monofluorophosphate. Bone Miner 1992;17:(Suppl 1):1165.

    Google Scholar 

  26. O'Duffy JD, Wahner HW, O'Fallon WM, Johnson KA, Muhs JM, Beabout JW, et al. Mechanism of acute lower extremity pain syndrome in fluoride-treated osteoporotic patients. Am J Med 1986;80:561–66.

    Google Scholar 

  27. Boivin G, Grousson B, Meunier PJ. X-ray microanalysis of fluoride distribution in microfracture calluses in cancellous iliac bone from osteoporotic patients treated with fluoride and untreated. J Bone Miner Res 1991;11:1183–90.

    Google Scholar 

  28. Farley SMG, Wergedal JE, Smith LC, Lundy LW, Farley JR, Baylink DJ. Fluoride therapy for osteoporosis: characterization of skeletal response by serial measurements of serum alkaline phosphatase activity. Metabolism 1987;36:211–8.

    Google Scholar 

  29. Duursma SA, Raymakers JA, Kappelle JW, van Dijk A, Glerum JH. Urinary fluoride excretion in responders and nonresponders after fluoride therapy in osteoporosis. In: Proceedings of an International Workshop on Fluoride and Bone, Niagara-on-the-Lake, Ontario, Canada Oct. 1988.

  30. Delmas PD, Dupuis J, Duboeuf F, Chapuy MC, Meunier PJ. Treatment of vertebral osteoporosis with disodium monofluorophosphate: comparison with sodium fluoride. J Bone Miner Res 1990;5(Suppl 1):S143–7.

    Google Scholar 

  31. Resch H, Libanati C, Talbot J, Tabuenca M, Farley S, Bettica P, et al. Pharmacokinetic profile of a new fluoride preparation: sustained-release monofluorophosphate. Calcif Tissue Int 1994;54:7–11.

    Google Scholar 

  32. Ekstrand J, Ehrnebo M, Boreus LO. Fluoride bioavailability after intravenous and oral administration: importance of renal clearance and urine flow. Clin Pharmacol Ther 1978;23:329–37.

    Google Scholar 

  33. Briancon D, Quillet P, Duplan B, Chapuy MC, Arlot M, Meunier PJ. Comparaison de la biodisponabilité du fluor à la suite de l'administration de fluorure de sodium seul ou en association avec calcium. Therapie 1988;43:107–10.

    Google Scholar 

  34. Arnold P, Wermeille M, Chapuy MC, Biollaz J, Granjean EM, Schelling JL, Meunier PJ. Influence of food and antacid administration on fluoride bioavailability from enteric-coated sodium fluoride tablets. Bone 1989;10:401–7.

    Google Scholar 

  35. Warneke G, Setnikar I. Effects of meal on the pharmacokinetics of fluoride from oral monofluorophosphate. Drug Res 1993;43:590–5.

    Google Scholar 

  36. Setnikar I, Maurer H. Bioequivalence of sodium monofluorophosphate with sodium fluoride and compatibility with calcium. Arzneim Forsch/Drug Res 1990;40:994–99.

    Google Scholar 

  37. Boivin G, Chapuy M-C, Meunier PJ. Fluoride content in human iliac bone: results on controls, patients with fluorosis, and osteoporotic patients treated with fluoride. J Bone Miner Res 1988;3:497–502.

    Google Scholar 

  38. Gerster JC, Charhon SA, Jaeger P, Boivin G, Briancon D, Rostan A, et al. Bilateral fractures of femoral neck in patients with moderate renal failure receiving fluoride for spinal osteoporosis. BMJ 1983;287:723–5.

    Google Scholar 

  39. Hedlund LR, Gallagher JC. Increased incidence of hip fracture in osteoporotic women treated treated with sodium fluoride. J Bone Miner Res 1989;4:223–5.

    Google Scholar 

  40. Gutteridge DH, Price RI, Kent GN, Prince RL, Michell PA. Spontaneous hip fractures in fluoride-treated patients: potential causative factors. J Bone Miner Res 1990;(Suppl 1) 5:S205–15.

    Google Scholar 

  41. Schulz EE, Flowers C, Brin BN, Farley S, Baylink DJ. Axial and peripheral skeletal response to fluoride therapy in osteoporosis. In: Christiansen C, Johansen JS, Riis BJ, editors. Osteoporosis 1987, vol 2. Copenhagen: Osteopress ApS, 1987:857–9.

    Google Scholar 

  42. Riggs BL, Baylink DJ, Kleerekoper M, Lane JM, Melton LJ, Meunier PJ Incidence of hip fractures in osteoporotic women treated with sodium fluoride. J Bone Miner Res 1987;2:123–6.

    Google Scholar 

  43. Mackie IG, Ralis ZA, Leyshon RL, Lane L, Watkins G, Berry PFA. Treatment of bone weakness in patients with femoral neck fracture by fluoride, calcium and vitamin D. [Br] J Bone Joint Surg 1988;71:111–17

    Google Scholar 

  44. Heaney RL. Fluoride and osteoporosis. Ann Intern Med 1994;120:689–90.

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Ringe, J.D., Meunier, P.J. What is the future for fluoride in the treatment of osteoporosis?. Osteoporosis Int 5, 71–74 (1995). https://doi.org/10.1007/BF01623306

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF01623306

Navigation