Summary
Three dose levels each of dieldrin (0 mg, 0.04 mg, 0.2 mg), DDT (0 mg, 0.2 mg, 1.0 mg), and methoxychlor (0 mg, 0.6 mg, 3.0 mg) were used in a 33 completely randomized factorial design. All 27 possible compound and dose combinations were used in the study. Six fish were used per treatment. The fish were individually given doses of insecticidesper os in corn oil enclosed in gelatin capsules. The fish were dosed on alternate days, seven doses in all. On the fifteenth day, the fish were killed and the fat body analyzed for lipid content and residual insecticides.
Tissue storage of DDT and DDE increased when DDT and dieldrin were fed in combination. The same response had been noted in rats but was of much greater magnitude in fish. Dieldrin storage was reduced by the presence of either DDT or methoxychlor. The effect of methoxychlor was more pronounced than that of DDT. The effect of DDT on tissue dieldrin reduction is much less in fish than in rats. Feeding of DDT with methoxychlor resulted in decreased methoxychlor storage. The influence of dieldrin on increasing tissue methoxychlor was highly significant (P<.01) when fish were given doses of 3.0 mg methoxychlor. Insecticide interactions occur in fish, but large differences in these responses exist between fish and rats.
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Mayer, F.L., Street, J.C. & Neuhold, J.M. Organochlorine insecticide interactions affecting residue storage in rainbow trout. Bull. Environ. Contam. Toxicol. 5, 300–310 (1970). https://doi.org/10.1007/BF01539942
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DOI: https://doi.org/10.1007/BF01539942