Skip to main content
SpringerLink
Log in

Evaluation of glomerular function in individual kidneys using dynamic magnetic resonance imaging

  • Published:
Pediatric Radiology Aims and scope Submit manuscript

Abstract

We used the fast field-echo technique of magnetic resonance (MR) imaging with an intravenous bolus injection of paramagnetic contrast agent to evaluate glomerular function. The time-dependent curves of changes in signal intensity observed in the renal cortex and renal medulla brought about by the paramagnetic contrast agent allowed insight into excretory kinetics. The time at which the cortical and medullary curves cross, the cortico-medullary (C-M) junction time, was delayed with a decrease in glomerular function. The mean C-M junction time in both kidneys showed a significant inverse correlation with total creatinine clearance (Ccr), indicating the glomerular filtration rate. The C-M junction time in an individual kidney also showed an inverse correlation with individual Ccr in each kidney. Results suggest that dynamic MR imaging is a useful tool in evaluating renal morphology and in evaluating semi-quantitatively the glomerular function of the kidneys, singly and together, in a manner analogous to radionuclide scintigraphy.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Hricack H, Crooks L, Sheldon P, Kaufman L (1983) Nuclear magnetic resonance of the kidney. Radiology 146: 425–432

    PubMed  Google Scholar 

  2. Thickman D, Kundel H, Biery D (1984) Magnetic resonance evaluation of hydronephrosis in dog. Radiology 152: 113–116

    PubMed  Google Scholar 

  3. Terrier RF, Hricak H, Revel D, et al (1985) Magnetic resonance imaging in the diagnosis of acute renal allograft rejection and its differentiation from acute tubular necrosis: experimental study in the dog. Invest Radiol 20: 617–625

    PubMed  Google Scholar 

  4. Yuasa Y, Kundel HL (1985) Magnetic resonance imaging following unilateral occlusion of the renal circulation in rabbits. Radiology 154: 151–156

    PubMed  Google Scholar 

  5. Hircak H, Terrier F, Demas BE (1986) Renal allografts: evaluation by MR imaging. Radiology 159: 435–441

    PubMed  Google Scholar 

  6. Carvlin MJ, Arger PH, Kundel HL, Axel L, Dougherty L, Kassab EA, Moore B (1987) Acute tubular necrosis: use of gadolinium-DTPA and fast imaging to evaluate renal function in the rabbit. J Comput Assist Tomogr 11: 488–495

    PubMed  Google Scholar 

  7. Kikinis R, von Schulthess GK, Jager P, Durr R, Bino M, Kuoni W, Kubler O (1987) Normal and hydronephrotic kidney: evaluation of renal function with contrast-enhanced MR imaging. Radiology 165: 837–842

    PubMed  Google Scholar 

  8. Carvlin MJ, Arger PH, Kundel HL, Axel L, Dougherty L, Kassab EA, Moore B (1989) Use of Gd-DTPA and fast-gradient-echo and spin-echo MR imaging to demonstrate renal function in the rabbit. Radiology 170: 705–711

    PubMed  Google Scholar 

  9. von Schulthess GK, Kuoni W, Gerig G, Wuthrich R, Duewell S, Krestin G (1991) Semiautomated ROI analysis in dynamic MR studies. Part II: application to renal function examination. J Comput Assist Tomogr 15: 733–741

    PubMed  Google Scholar 

  10. Takeda M, Katayama Y, Sato S, Odano I (1990) Value of dynamic magnetic resonance imaging in hydronephrosis. J Urol 143: 258A

    Google Scholar 

  11. Togami I, Murakami K, Tsunoda M, Kitagawa N, Sato N, Kimoto M (1991) Evaluation of renal function using dynamic MRI with Gd-DTPA — comparison with dynamic CT and renogram using 99mTc-DTPA on normal volunteer. Jpn J Med Imaging 10: 138–146

    Google Scholar 

  12. Felix R, Schorner M (1985) Brain tumors: MR imaging with gadolinium-DTPA. Radiology 156: 681–688

    PubMed  Google Scholar 

  13. Ohtomo K, Itai Y, Yoshikawa K (1987) Hepatic tumors: dynamic MR imaging. Radiology 163: 27–31

    PubMed  Google Scholar 

  14. Fuchs WA (1989) Renal morphology and function in magnetic resonance imaging. In: Margulis A (ed) Morphology and function in MRI. Springer, Berlin Heidelberg New York, pp 111–131

    Google Scholar 

  15. Mirowitz SA, Brown JJ, Joseph KT, Heiken JP (1991) Dynamic gadoliniumenhanced MR imaging of the spleen: normal enhancement patterns and evaluation of splenic lesions. Radiology 179: 681–686

    PubMed  Google Scholar 

  16. Takeda M, Katayama Y, Tsutsui T, Komeyama T, Mizusawa T (1994) Does gadolinium-diethylenetriamine pentaacetic acid enhanced MRI of kidney represent tissue concentration of contrast media in the kidney? In vivo and in vitro study. Magn Reson Imaging 12: 421–427

    PubMed  Google Scholar 

  17. Weinmann HJ, Brasch RC, Press WR, Wesbey GF (1989) Characteristics of gadolinium-DTPA complex: a potential NMR contrast agent. AJR 142: 619–624

    Google Scholar 

  18. Frank JA, Choyko PL, Austin HA, Girton ME (1991) Functional MR of the kidney. Magn Reson Med 22: 319–323

    PubMed  Google Scholar 

  19. Krestin GP (1994) Magnetic resonance imaging of the kidneys: current status. Magn Reson Q 10: 2–21

    PubMed  Google Scholar 

  20. Lorenz CH, Powers TA, Partain CL (1992) Quantitative imaging of renal blood flow and function. Invest Radiol 27: S109-S114

    PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Pediatrics, Juntendo University School of Medicine, 2-1-1, Hongo, 113, Bunkyo-ku, Tokyo, Japan

    Y. Fukuda, H. Watanabe & K. Yabuta

  2. Department of Radiology, Juntendo University School of Medicine, Tokyo, Japan

    T. Tomita & H. Katayama

  3. Department of Pediatric Surgery, Juntendo University School of Medicine, Tokyo, Japan

    T. Miyano

Authors
  1. Y. Fukuda
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. H. Watanabe
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. T. Tomita
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. H. Katayama
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. T. Miyano
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. K. Yabuta
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Fukuda, Y., Watanabe, H., Tomita, T. et al. Evaluation of glomerular function in individual kidneys using dynamic magnetic resonance imaging. Pediatr Radiol 26, 324–328 (1996). https://doi.org/10.1007/BF01395707

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF01395707

Keywords

Search

Navigation