Abstract
Tropomyosin polymerization is inhibited by DNAse I, an endonuclease which also interacts with G-actin. A 1:4 molar ratio of DNAse I to adult chicken pectoralis muscle tropomyosin almost completely prevents the increased viscosity of tropomyosin under polymerizing ionic conditions. While G-actin binding to DNAse I inhibits the DNAse I hydrolysis of DNA, tropomyosin does not affect this enzymatic activity. G-actin-DNAse I interaction is also not altered by tropomyosin.
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Payne, M.R., Rudnick, S.E. Inhibition of muscle tropomyosin polymerization by DNAse I. Biosci Rep 6, 721–726 (1986). https://doi.org/10.1007/BF01116539
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DOI: https://doi.org/10.1007/BF01116539